Urinary biomarkers of inflammation and tissue remodeling may predict bladder dysfunction in patients with benign prostatic hyperplasia

Conti, P.; Barbosa, João Arthur Brunhara Alves; Reis, Sabrina T.; Viana, Nayara; Gomes, Cristiano Mendes; Borges, Leonardo Lima; Nunes, Marco; Nahas, William Carlos; Srougi, Miguel; Antunes, Alberto A.

doi:10.1007/s11255-020-02537-4

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Although men with voiding predominant LUTS are usually diagnosed as having clinical benign prostatic hyperplasia (BPH), half of the patients with LUTS are actually resulted from different LUTD such as DO, DU, HSB, BND, DV, poor urethral sphincter relaxation, or IC/BPS[ 3 , 83 , 84 , 85 ]. Behind these LUTD, the pathophysiology of chronic bladder ischemia, BOO-induced bladder fibrosis, increased sensory hyperactivity, and neurogenic inflammation might produce different urinary proteins and biomarkers that lead to different functional and morphological modulations[ 24 , 86 , 87 , 88 , 89 , 90 ]. Therefore, it seems rational to measure the urinary biomarkers in discriminating different LUTD such as IC/BPS, DO, BOO, DO, HSB, and PRES in men with LUTS.…”

Section: Ale Lower Urinary Tract Dysfunctionsmentioning

confidence: 99%

Urine biomarker could be a useful tool for differential diagnosis of a lower urinary tract dysfunction

Yu,

Jiang,

Jhang

et al. 2023

Tzu Chi Medical Journal

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A precision diagnosis of lower urinary tract dysfunctions (LUTD) such as bladder outlet obstruction, detrusor overactivity (DO), interstitial cystitis/bladder pain syndrome (IC/BPS), dysfunctional voiding (DV), or detrusor underactivity (DU) needs invasive videourodynamic study. Exploring non-invasive tools to help screening LUTD is necessary for clinicians in their daily practice. This article reviews recently clinical studies of using urinary inflammatory proteins and oxidative stress biomarkers in the identification of specific LUTD among men and women with lower urinary tract symptoms (LUTS). Some important findings have been reported: (1) Using urine chemokines CXCL-1 and interleukin-8 (IL-8), we may discriminate overactive bladder (OAB) symptoms in women between DO and urinary tract infection. (2) Urinary levels of oxidative stress biomarkers such as 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane have a potential being used as a tool to identify women with mixed DO and stress urinary incontinence. (3) Urine levels of total antioxidant capacity (TAC), and prostaglandin E2 (PGE2) are positively correlated with voiding detrusor pressure in patients with DU. (4) Urine levels of brain-derived neurotrophic factor (BDNF) and PGE2 were significantly higher in the DU patients with detrusor function recovery. (5) Women with DV had higher urinary levels of tumor necrosis factor-alpha (TNF-α) and 8-OHdG, and urinary IL-2 level was significantly lower. (6) Urine level of 8-isoprostane was higher in the patients with idiopathic DO and neurogenic DO. (7) Higher urine cytokine levels of monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted (RANTES), CXCL-10, IL-7, and eotaxin-1 in patients with IC/BPS than controls. (8) The urine levels of IL-8, CXCL-10, BDNF, IL-6, and RANTES were significantly higher in patients with Hunner’s IC than non-Hunner’s IC. (9) Male patients with IC/BPS had a significantly higher level of eotaxin, MCP-1, TNF-α, 8-OHdG, and TAC. Combining a higher eotaxin and a higher TNF-α can provide a satisfactory diagnostic value in discriminating IC/BPS from other LUTD in men. These studies provide evidence that measurement of cluster of urine biomarkers could be used as a diagnostic tool to differentiate different LUTD in patients with similar LUTS.

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Section: Ale Lower Urinary Tract Dysfunctionsmentioning

confidence: 99%

Urine biomarker could be a useful tool for differential diagnosis of a lower urinary tract dysfunction

Yu,

Jiang,

Jhang

et al. 2023

Tzu Chi Medical Journal

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“…Urinary proteins have been considered to represent the condition of kidney diseases and reflect the bladder conditions after BOO [18,19]. A previous study found urinary levels of epidermal growth factor, matrix-metalloproteinase-1, interleukin-6 (IL-6), nerve growth factor (NGF), and monocyte-chemoattractant protein-1 (MCP-1), representing inflammation and tissue remodeling, can be used to predict bladder dysfunction in men with LUTS and persistent postoperative detrusor overactivity (DO) [20]. In addition, urinary NGF, brain-derived neurotrophic factor (BDNF), and prostaglandin E2 (PGE2) are increased in many OAB patients and these biomarkers can help identify OAB phenotypes [21,22].…”

Section: Introductionmentioning

confidence: 99%

Use of Urinary Biomarkers in Discriminating Interstitial Cystitis/Bladder Pain Syndrome from Male Lower Urinary Tract Dysfunctions

Jiang

Jhang

et al. 2023

IJMS

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To analyze the urinary biomarkers in men with lower urinary-tract symptoms (LUTS) and identify interstitial cystitis/bladder pain syndrome (IC/BPS) from the other lower urinary-tract dysfunctions (LUTDs) by the levels of characteristic urinary biomarkers. In total, 198 men with LUTS were prospectively enrolled and urine samples were collected before intervention or medical treatment. Videourodynamic studies were routinely performed and the LUTDs were diagnosed as having bladder-outlet obstruction (BOO) such as bladder-neck dysfunction, benign prostatic obstruction, or poor relaxation of external sphincter (PRES); and bladder dysfunction such as detrusor overactivity (DO), hypersensitive bladder (HSB), and IC/BPS. Patients suspicious of IC/BPS were further confirmed by cystoscopic hydrodistention under anesthesia. The urine samples were investigated for 11 urinary inflammatory biomarkers including eotaxin, IL-6, IL-8, CXCL10, MCP-1, MIP-1β, RANTES, TNF-α, NGF, BDNF, and PGE2; and 3 oxidative stress biomarkers 8-OHdG, 8-isoprostane, and TAC. The urinary biomarker levels were analyzed between LUTD subgroups and IC/BPS patients. The results of this study revealed that among the patients, IC/BPS was diagnosed in 48, BOO in 66, DO in 25, HSB in 27, PRES in 15, and normal in 17. Patients with BOO had a higher detrusor pressure and BOO index than IC/BPS, whereas patients with IC/BPS, BOO, and DO had a smaller cystometric bladder capacity than the PRES and normal subgroups. Among the urinary biomarkers, patients with IC/BPS had significantly higher levels of eotaxin, MCP-1, TNF-α, 8-OHdG, and TAC than all other LUTD subgroups. By a combination of different characteristic urinary biomarkers, TNF-α, and eotaxin, either alone or in combination, had the highest sensitivity, specificity, positive predictive value, and negative predictive value to discriminate IC/BPS from patients of all other LUTD subgroups, BOO, DO, or HSB subgroups. Inflammatory biomarker MCP-1 and oxidative stress biomarkers 8-OHdG and TAC, although significantly higher in IC/BPS than normal and PRES subgroups, did not have a diagnostic value between male patients with IC/BPS and the BOO, DO, or HSB subgroups. The study concluded that using urinary TNF-α and eotaxin levels, either alone or in combination, can be used as biomarkers to discriminate patients with IC/BPS from the other LUTD subgroups in men with LUTS.

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“…Urinary biomarkers produced by prostatic epithelial and stromal cells (PrSC) and prostatic epithelial cells (PrEC) could be altered in several conditions influencing bladder activity. 5 , 6 , 7 , 8 , 9 To date, the alteration of urinary protein markers and their associated cytokines in LUTS as a consequence of prostatic inflammation remain unknown.…”

Section: Introductionmentioning

confidence: 99%

“… 12 Furthermore, MCP-1/creatinine (Cr) as urinary biomarkers of inflammation and tissue remodeling for prediction of bladder dysfunction in BPH was also associated with the presence of detrusor overactivity in the urodynamic study. 5 …”

Section: Introductionmentioning

confidence: 99%

Thai traditional massage modulates urinary MCP-1 and relevant inflammatory biomarkers in lower urinary tract symptom patients

Sinsomboon¹,

Kuendee

Naladta

et al. 2023

Journal of Traditional and Complementary Medicine

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Urinary biomarkers of inflammation and tissue remodeling may predict bladder dysfunction in patients with benign prostatic hyperplasia

Cited by 5 publications

References 28 publications

Urine biomarker could be a useful tool for differential diagnosis of a lower urinary tract dysfunction

Urine biomarker could be a useful tool for differential diagnosis of a lower urinary tract dysfunction

Use of Urinary Biomarkers in Discriminating Interstitial Cystitis/Bladder Pain Syndrome from Male Lower Urinary Tract Dysfunctions

Thai traditional massage modulates urinary MCP-1 and relevant inflammatory biomarkers in lower urinary tract symptom patients

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