Urinary Bisphenol a and Semen Quality: The Life Study

Goldstone, Alexandra E.; Chen, Zhe; Perry, Melissa J.; Kannan, Kurunthachalam; Louis, Germaine M. Buck

doi:10.1016/j.annepidem.2014.06.087

Cited by 4 publications

(6 citation statements)

References 32 publications

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“…In turn, the cohort studies by Goldstone et al . () aimed at an estimation of the association between BPA and 35 measures of semen quality among reproductive aged men, did not show any evidence that BPA decreased semen quality in the examined group. Only DNA fragmentation was significantly associated with urinary BPA concentrations (β = −0.0544, P = 0.035).…”

Section: Effect Of Bisphenol a On Male Reproductive Processes And Fermentioning

confidence: 85%

Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies

Tomza–Marciniak

Stępkowska

Kuba

et al. 2017

J of Applied Toxicology

118

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As bisphenol A (BPA) is characterized by a pronounced influence on human hormonal regulation, particular attention has been aimed at understanding its role in reproductive processes in males and females, as well as on fetal development. Owing to the increasing number of alarming reports on the negative consequences of the presence of BPA in human surroundings, more and more studies are being undertaken to clarify the negative effects of BPA on human reproductive processes. The aim of this work was to collect and summarize data on the influence of BPA exposure on reproductive health. Based on an analysis of selected publications it was stated that there is strong proof confirming that BPA is an ovarian, uterine and prostate toxicant at a level below the lowest observed adverse effect level (50 mg kg À1 bodyweight) as well as a level below the proposed safe level (4 μg kg À1 bodyweight). It seems there is also reliable evidence in relation to the negative effect of BPA on sperm quality and motility. Limited evidence also pertains to the case of the potential of BPA to affect polycystic ovary syndrome occurrence. Although in epidemiological studies this disease was common, in studies on animal models such results were still not confirmed. No unambiguous results of epidemiological studies and with animal models were obtained in relation to the evaluation of associations between BPA and implantation failure in women, evaluation of associations between BPA and sexual dysfunction in men, and impact of BPA on birth rate, birth weight and length of gestation.

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Section: Effect Of Bisphenol a On Male Reproductive Processes And Fermentioning

confidence: 85%

Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies

Tomza–Marciniak

Stępkowska

Kuba

et al. 2017

J of Applied Toxicology

118

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“…While 89% of samples in this population of subfertile men had detectable BPA concentrations, overall these men had relatively low urinary BPA concentrations [unadjusted geomean (GM) (IQR) was 1.6 (0.8, 2.3) ng/mL]. In the two other studies which included men from couples trying to conceive naturally, BPA was not associated with semen parameters despite having similar urinary BPA concentrations to the previous study of subfertile men (36, 38). For instance, Mendiola and colleagues investigated the relation of urinary BPA concentrations and sperm parameters in 315 fertile men from the Study for Future Families (SFF), a multicenter study of couples recruited at prenatal clinics in four U.S. cities (Los Angeles, CA; Minneapolis, MN; Columbia, MO; and Iowa City, IA) who conceived without medical assistance between 1999 and 2005 (38).…”

Section: Bpa and Semen Qualitymentioning

confidence: 51%

“…Of note, this population had low background urinary BPA concentrations [median (5 th –95 th percentiles) unadjusted urinary BPA concentration was 3.3 ng/mL (0.6, 14.9 ng/mL)] (35). The associations of BPA with semen parameters and DNA damage has also been assessed in several studies of men who, along with their partners, were trying to conceive (36–38). Meeker and coworkers explored the association of urinary BPA concentrations with semen parameters and DNA damage in 190 male partners of subfertile couples seeking treatment at Massachusetts General Hospital (MGH) in Boston, Massachusetts (2000–2004) (37).…”

Section: Bpa and Semen Qualitymentioning

confidence: 99%

“…Urinary BPA concentrations (GM (IQR) was 1.5 (0.8, 3.0) ng/mL) were not associated with any of the examined semen parameters in this study. Similarly, Goldstone and coworkers assessed the association of urinary BPA concentrations with sperm parameters in 418 men included in the Longitudinal Investigation of Fertility and the Environment (LIFE) Study (2005–2009), a cohort study which followed couples attempting pregnancy in Michigan and Texas (36). Urinary BPA concentrations [unadjusted GM (5 th , 95 th ) was 0.6 ng/mL (95% CI 0.5, 0.6 ng/mL)] were not associated with semen parameters among these men.…”

Section: Bpa and Semen Qualitymentioning

confidence: 99%

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Effects of bisphenol A on male and couple reproductive health: a review

Mínguez-Alarcón

Hauser

Gaskins

2016

Fertility and Sterility

119

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Bisphenol A (BPA) is a ubiquitous environmental toxicant with endocrine-disrupting properties and suspected to affect human reproduction. Yet in humans, the studies exploring the effect of this BPA on male reproductive health including semen quality, reproductive hormones, and couple fecundity and fertility, have produced inconsistent results. The objective of this manuscript was to summarize the effects of male exposure to BPA on markers of testicular function and couple reproductive outcomes. Of the five studies on male BPA exposure and reproductive hormones, all found significant associations with at least one reproductive hormone; however no consistent relations were observed across studies. Similarly, five studies evaluated the relation between BPA and semen quality and while the majority reported negative associations with various parameters, there were few consistent trends across studies. Finally, the three studies which have examined male urinary BPA levels and couple reproductive outcomes did not find associations, with the exception being a link with lower secondary sex ratio (or greater female excess). Overall, while the literature on this topic is growing, the evidence supporting a link between male BPA exposure and male reproductive health remains limited and inconclusive. Reasons for the discrepancies in results could include, but are not limited to, differences in: study populations (e.g. fertile vs. subfertile men), BPA exposure levels (occupationally exposed vs. non-occupationally exposed), study procedures used to collect and measure urinary BPA (e.g. using one urine sample to characterize exposure vs. multiple samples), sample sizes, and study design (e.g. cross-sectional vs. prospective). Based on the available evidence, there is insufficient evidence to conclude that exposure to BPA, at low to moderate levels, has a negative effect on reproductive outcomes in men. Clearly, further studies are needed to further clarify the role of this ubiquitous endocrine disrupting chemical on male reproductive health.

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“…Interest in non-persistent chemicals, or those compounds with short half-lives ranging from hours to days, is growing in light of their ubiquitous sources of exposure for contemporary populations and reported association with semen quality. For example, both bisphenol A (BPA) and phthalates, or chemicals used in the manufacture of polycarbonate plastics and to enhance the flexibility of plastics among other uses, respectively, have been associated with diminished semen quality in some (4, 5) but not all (6, 7) study populations.…”

Section: Introductionmentioning

confidence: 99%

Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality

Louis

Chen

Kim

et al. 2015

Fertility and Sterility

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Objective To assess benzophenone-type ultra violet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. Design Cohort. Setting 16 counties in Michigan and Texas Participants 413 men provided semen and urine samples, 2005–2009. Five UV filters were quantified (ng/mL) in urine using liquid chromatography-triple-quadrupole mass spectrometry: BP-1 (2,4-dihydroxybenzophenone), BP-2 (2,2′,4,4′-tetrahydroxybenzophenone), BP-3 (2-hydroxy-4-methoxybenzophenone), BP-8 (2,2′-dihydroxy-4-methoxybenzophenone), and 4-OH-BP (4-hydroxybenzophenone). Using linear regression, beta coefficients (β) and 95% confidence intervals (CIs) for each chemical dichotomized at the 75th percentile and Box-Cox transformed semen endpoint were estimated, after adjusting for age, BMI, cotinine, season, and site. Interventions None. Main Outcome Measures 35 semen endpoints. Results BP-2 was associated with diminished sperm concentration (β=−0.74; 95% CI −1.41, −0.08), straight (β=−4.57; 95% CI −8.95, −0.18) and linear movement (β=−3.15; 95% CI −6.01, −0.30), more immature (β=0.38; 95% CI 0.15, 0.62) sperm, and a decreased percentage of other tail abnormalities (β=−0.16; 95% CI −0.31, −0.01). BP-8 was associated with decreased hypo-osmotic swelling (β=−2.57; 95% CI −4.86, −0.29) and higher acrosome area (β=1.14; 95% CI 0.01, 2.26). No associations were observed for BP-1, BP-3 or 4OH-BP. Conclusion The findings suggest that specific UV filters may be associated with some aspects of semen endpoints, but await future corroboration.

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Urinary Bisphenol a and Semen Quality: The Life Study

Cited by 4 publications

References 32 publications

Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies

Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies

Effects of bisphenol A on male and couple reproductive health: a review

Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality

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