Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

Melzer, David; Osborne, Nicholas J.; Henley, William; Cipelli, Riccardo; Young, Anita; Money, Cathryn; McCormack, Paul; Luben, Robert; Khaw, Kay‐Tee; Wareham, Nicholas J.; Galloway, Tamara S.

doi:10.1161/circulationaha.111.069153

Cited by 262 publications

(198 citation statements)

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“…It would be of considerable interest to determine the effects of BPA on ESRRA expression and metabolic activity in a wider range of different cell types, especially in light of the associations previously reported between exposure to BPA and metabolic diseases (Melzer et al 2012a(Melzer et al , 2012b. ERRa is present in a wide variety of cell types and is highly expressed in cells with elevated metabolic demand such as heart, skeletal muscle and brown adipose tissue (Eichner & Giguère 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Positive prospective associations have been reported between BPA exposure and a range of reproductive and developmental conditions including recurrent miscarriage (SugiuraOgasawara et al 2005) and externalising behaviour scores in the offspring of exposed mothers (Braun et al 2011). Urinary BPA concentrations were associated with cardiovascular disease diagnosis in large scale crosssectional (Lang et al 2008, 2012a and longitudinal studies (Melzer et al 2012b).…”

Section: Introductionmentioning

confidence: 95%

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Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells

Cipelli¹,

Harries²,

Okuda³

et al. 2014

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Bisphenol A (BPA) is a widely used plastics constituent that has been associated with endocrine, immune and metabolic effects. Evidence for how BPA exerts significant biological effects at chronic low levels of exposure has remained elusive. In adult men, exposure to BPA has been associated with higher expression of two nuclear receptors, oestrogen receptor-b (ERb) and oestrogen-related-receptor-a (ERRa), in peripheral white blood cells in vivo. In this study, we explore the expression of ESR2 (ERb) and ESRRA (ERRa) in human leukaemic T-cell lymphoblasts (Jurkat cells) exposed to BPA in vitro. We show that exposure to BPA led to enhanced expression of ESRRA within 6 h of exposure (meanGS.E.M.: 1.43G0.08-fold increase compared with the control, P!0.05). After 72 h, expression of ESRRA remained significantly enhanced at concentrations of BPA R1 nM. Oxidative metabolism of BPA by rat liver S9 fractions yields the potent oestrogenic metabolite, 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP). Exposure of cells to 1-100 nM MBP increased the expression of both ESRRA (significantly induced, P!0.05, at 1, 10, 100 nM) and ESR2 (1.32G0.07-fold increase at 100 nM exposure, P!0.01). ERRa is a major control point for oxidative metabolism in many cell types, including T-cells. Following exposure to both BPA and MBP, we found that cells showed a decrease in cell proliferation rate. Taken together, these results confirm the bioactivity of BPA against putative T-cell targets in vitro at concentrations relevant to general human exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells

Cipelli¹,

Harries²,

Okuda³

et al. 2014

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“…Several investigators found that higher BPA concentrations were associated with cardiovascular diagnoses (Lang et al 2008;vom Saal and Myers 2008;Melzer et al 2010) and incident coronary artery disease (Melzer et al 2012). In addition, Asano et al (2010) reported that BPA in the micromolar range activates Maxi-K (KCa1.1) ion channels in human coronary smooth muscle cells in culture to a degree sufficient to hyperpolarize the membrane potential.…”

Section: Introductionmentioning

confidence: 99%

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Khadrawy²,

2013

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Bisphenol A (BPA) is an endocrine disrupting chemical used on a wide range in industry. Several studies reported that BPA may cause cardiovascular disorders in humans and animals. The present study aims to investigate the effect of BPA on the heart of adult male rats. The rats received a daily oral administration of BPA (25 mg/kg for 6 weeks and 10 mg/kg for 6 and 10 weeks). It was found that BPA at the two studied doses induced a significant increase in malondialdehyde, and a significant decrease in catalase after 6 weeks. Moreover, a significant decrease in reduced glutathione and acetylcholinesterase (AchE) activity was observed after treatment with the two doses of BPA throughout the studied time intervals. The two doses (25 and 10 mg/kg) resulted in a significant decrease in nitric oxide (NO) levels after 6 and 10 weeks, respectively. A significant increase in body weight gain occurred in all animals after BPA treatment. These results suggest that BPA has cardiotoxic effects which are mediated by the oxidative stress resulting from the overproduction of free radicals, the deficiency of NO and the inhibition of AchE leading to cholinergic activation. The obesity promoting effect of BPA may also participate in the observed cardiovascular disturbances.

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“…More recently, a nested case-control study reported the association between higher BPA exposure and incident coronary artery disease with a dose-response relationship. 16 However, the knowledge on how BPA affects the cardiovascular system is still limited.The cells of the cardiovascular system have estrogen receptors (␣ and ␤). These receptors are involved in antiatherogenic actions, vasodilation and preservation of vascular integrity, cardiomyocyte survival, and regulation of excitability of smooth muscle cells.…”

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confidence: 99%

Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure

et al. 2012

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Abstract-Bisphenol A (BPA) is a high-volume production chemical that has been suspected to have adverse health effects.Recent studies have suggested that cardiovascular diseases are associated with the BPA exposure. The aim of present study was to investigate the associations of urinary BPA with heart rate variability and blood pressure. We recruited 560 noninstitutionalized elderly citizens from August 2008 to August 2010 in Seoul. All of the participants were Ն60 years old. The participants took medical examinations Յ5 times. Urinary BPA concentration, heart rate variability, and blood pressure were measured at each time. A total of 1511 observations from 521 participants were included in the analyses. We observed that urinary BPA was associated negatively with the root mean square of successive differences for heart rate and positively with blood pressure. BPA is considered to be an endocrine-disrupting chemical, and it shows affinity for estrogen receptors. It was initially considered to be a weak xenoestrogen, but subsequent studies showed that BPA can have effects even at low concentrations.3 In addition, pathways other than binding to estrogen receptors have been proposed. These include the thyroid hormone pathway, binding to glucocorticoid receptors and androgen receptors, or interfering with the central nervous system and immune system. [4][5][6] Epidemiological studies have suggested that BPA could have adverse effects on human health.7 Specifically, BPA exposure has been shown to be associated with increased production of liver enzymes, 8 recurrent miscarriages, 9 premature delivery of fetuses, 10 inflammation and oxidative stress, 11 decreased quality of semen, 12,13 and male sexual dysfunction. 14 In 2008, Lang et al 8 conducted a study investigating the associations between past history of chronic diseases and BPA concentration by analyzing data sets from the National Health and Nutrition Examinations Survey. They reported that the concentration of urinary BPA was associated with history of diabetes mellitus and cardiovascular diseases (CVDs).8 Later, Melzer et al 15 conducted similar analyses using larger National Health and Nutrition Examinations Survey data sets and found association between the concentration of BPA and CVDs but not with diabetes mellitus. More recently, a nested case-control study reported the association between higher BPA exposure and incident coronary artery disease with a dose-response relationship. 16 However, the knowledge on how BPA affects the cardiovascular system is still limited.The cells of the cardiovascular system have estrogen receptors (␣ and ␤). These receptors are involved in antiatherogenic actions, vasodilation and preservation of vascular integrity, cardiomyocyte survival, and regulation of excitability of smooth muscle cells. 17,18 As a xenoestrogen, BPA may alter these functions of estrogen receptors by mimicking or blocking the action of estrogen. 19 We hypothesized that exposure to BPA is associated with reduced heart rate variability (HRV) and hyperten...

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Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

Cited by 262 publications

References 53 publications

Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells

Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure

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