Urinary bisphenol concentrations and its association with metabolic disorders in the US and Korean populations

Choi, Ji Yoon; Lee, Jiyun; Huh, Da An; Moon, Kyong Whan

doi:10.1016/j.envpol.2021.118679

Cited by 31 publications

(13 citation statements)

References 64 publications

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“…Currently, BPF and BPS have also been identified with estrogenic and anti-androgenic features because these analogs have similar chemical structures to BPA [ 20 ]. Additionally, as per in vitro and in vivo studies, they cause similar endocrine alterations and adverse physiological effects [ 14 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

et al. 2022

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Background Bisphenol A (BPA) exposure and its structural analogs (BPS and BPF) might cause endocrine alterations and adverse physiological effects. Few studies to date have directly explored the association between its structural analogs (BPS, BPF) and sex hormones in adult male participants. Therefore, we aimed to assess the associations between BPA, BPS, BPF, and sex hormones in American adult men. Methods We used data from the U.S. National Health and Nutrition Examination Survey 2011–2016. We excluded participants without data available on sex hormones and urinary bisphenols. Furthermore, participants consuming sex hormone medications were excluded. Multivariable regression models were performed to assess the association between bisphenols and sex hormones. Results In this study, 2367 participants were included. Of 2367, in 1575 participants, the data on BPS and BPF were available. We found that a per unit increase in BPF was associated with 0.575 ng/dL higher total testosterone (TT) (Model 2: 95% CI: 0.047, 1.103, P = 0.033). However, there was no significant association between BPA or BPS and TT. Furthermore, increased BPA and BPS levels were associated with higher levels of sex hormone-binding globulin (SHBG) (Model 2: β = 0.364, 95% CI: 0.158, 0.571; β = 0.25, 95% CI: 0.071, 0.429, respectively). Additionally, participants in the highest BPA exposure quartile (quartile 4) had 4.072 nmol/L higher levels of SHBG than those in quartile 1 (Model 2: 95% CI: 0.746, 7.397, P = 0.017; P for trend =0.005). Both BPA and BPS were negatively associated with free testosterone (FT, nmol/L) after full adjustment (Model 2, β = − 0.01%, P = 0.0211, P = 0.0211; Model 2, β = − 0.01%, P = 0.0258, respectively). However, BPF was positively associated with FT (Model 2, β = 0.0029%, P = 0.0028). Conclusion Our study indicated that exposure to both BPA and its substitutions could alter sex hormone levels. This finding supports the possibility that human exposure to bisphenols at environmental levels might affect the endogenous hormone balance.

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Section: Introductionmentioning

confidence: 99%

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

et al. 2022

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“…In each study, chemicals were determined in an appropriate biological matrix (blood, plasma and urine) with specific analytical methods (HPLC-MS/MS; GC-HRMS; ICP-MS). The sample size ranged from 621 [ 62 ] to 4314 [ 56 ]; in all studies, men comprised about 50%.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies highlighted the relevance of gender factors, such as race/ethnicity or geographical areas, in relation to several metabolic factors and bisphenol exposure [ 56 ]. The first study examined the role of race/ethnicity in US adults in relation to the associations between bisphenol levels and obesity using the American National Health and Nutrition Examination Survey (NHANES, 2013–2014).…”

Section: Resultsmentioning

confidence: 99%

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Sex and Gender Differences on the Impact of Metabolism-Disrupting Chemicals on Obesity: A Systematic Review

D’Archivio,

Coppola,

Masella

et al. 2024

Nutrients

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Obesity represents an important public health concern, being one of the leading causes of death worldwide. It is a multifactorial disease with many underlying intertwined causes, including genetic, environmental and behavioral factors. Notably, metabolism-disrupting chemicals (MDCs) can alter the set point control of metabolism, affecting the development and function of the adipose tissue. Epidemiological studies have reported associations between human exposure to MDCs and several altered metabolic endpoints. It is also noteworthy that sex and gender represent important risk factors in the development of obesity. Different sex-related biological and physiological characteristics influence individual susceptibility, whereas gender represents a critical component in determining the different exposure scenarios. Although some advancements in the treatment of obesity have been achieved in preclinical and clinical studies, the obesity pandemic continues to increase worldwide. The present study performed a systematic review of recent studies considering the effects of MDCs on obesity, with a specific focus on sex- and gender-related responses. This review highlighted that MDCs could differently affect men and women at different stages of life even though the number of studies evaluating the association between obesity and MDC exposure in relation to sex and gender is still limited. This evidence should urge researchers to carry out studies considering sex and gender differences. This is essential for developing sex-/gender-tailored prevention strategies to improve public health policies and reduce exposure.

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“…Bisphenol A (BPA) is an artificial chemical compound with high production volume, predominantly used in manufacturing polycarbonate (PC) plastics, polysulfones, and epoxy resins ( 1 , 2 ). Several studies suggest that BPA is widely applied in producing varying consumer products, such as thermal paper, can coatings ( 3 , 4 ), and BPA can leach from food and beverage containers, dental sealants, and other composites ( 5 ). Due to its widespread application, BPA is detected in water (freshwater, seawater, sewage, drinking water), soil or sediment, atmosphere, food, garbage ( 4 , 6 ), and in humans.…”

Section: Introductionmentioning

confidence: 99%

Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019

Zhang,

Li,

Wang

et al. 2024

Front. Public Health

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BackgroundBisphenol A (BPA) is an oil-derived, large-market volume chemical with endocrine disrupting properties and reproductive toxicity. Moreover, BPA is frequently used in food contact materials, has been extensively researched recently, and widespread exposure in the general population has been reported worldwide. However, national information on BPA levels in general Chinese people is lacking.MethodsThis study collected and analyzed 145 (104 in urine and 41 in serum) research articles published between 2004 and 2021 to reflect the BPA internal exposure levels in Chinese populations. The Monte Carlo simulation method is employed to analyze and estimate the data in order to rectify the deviation caused by a skewed distribution.ResultsData on BPA concentrations in urine and serum were collected from 2006 to 2019 and 2004 to 2019, respectively. Urinary BPA concentrations did not vary significantly until 2017, with the highest concentration occurring from 2018 to 2019 (2.90 ng/mL). The serum BPA concentration decreased to the nadir of 1.07 ng/mL in 2011 and gradually increased to 2.54 ng/mL. Nationally, 18 provinces were studied, with Guangdong (3.50 ng/mL), Zhejiang (2.57 ng/mL), and Fujian (2.15 ng/mL) having the highest urine BPA levels. Serum BPA was investigated in 15 provinces; Jiangsu (9.14 ng/mL) and Shandong (5.80 ng/mL) were relatively high. The results also indicated that males’ urine and serum BPA levels were higher than females, while the BPA levels in children were also higher than in adults (p < 0.001). Furthermore, the volume of garbage disposal (r = 0.39, p < 0.05), household sewage (r = 0.34, p < 0.05), and waste incineration content (r = 0.35, p < 0.05) exhibited a strong positive connection with urine BPA levels in Chinese individuals.ConclusionDespite using a data consolidation approach, our study found that the Chinese population was exposed to significant amounts of BPA, and males having a higher level than females. Besides, the levels of BPA exposure are influenced by the volume of garbage disposal, household sewage, and waste incineration content.

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Urinary bisphenol concentrations and its association with metabolic disorders in the US and Korean populations

Cited by 31 publications

References 64 publications

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

Sex and Gender Differences on the Impact of Metabolism-Disrupting Chemicals on Obesity: A Systematic Review

Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019

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