Urinary Bladder, Ureter, and Urethra

Jokinen, Micheal P.; Seely, John C.

doi:10.1016/b978-0-12-391448-4.00012-5

Cited by 2 publications

(3 citation statements)

References 57 publications

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“…Urothelial ulceration was significantly associated with urolithiasis, which makes sense pathophysiologically as this disease is characterized by the presence of a urolith in the bladder lumen. The bladder stones cause physical trauma to urothelial cells, sometimes to the point of complete urothelial loss [ 15 , 38 ]. It is important to note that urothelial loss may also occur as a postmortem change or as part of tissue handling during biopsy.…”

Section: Discussionmentioning

confidence: 99%

Predicting Diagnosis of Australian Canine and Feline Urinary Bladder Disease Based on Histologic Features

Jones

Alawneh

Thompson

et al. 2020

Veterinary Sciences

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Anatomic pathology is a vital component of veterinary medicine but as a primarily subjective qualitative or semiquantitative discipline, it is at risk of cognitive biases. Logistic regression is a statistical technique used to explain relationships between data categories and outcomes and is increasingly being applied in medicine for predicting disease probability based on medical and patient variables. Our aims were to evaluate histologic features of canine and feline bladder diseases and explore the utility of logistic regression modeling in identifying associations in veterinary histopathology, then formulate a predictive disease model using urinary bladder as a pilot tissue. The histologic features of 267 canine and 71 feline bladder samples were evaluated, and a logistic regression model was developed to identify associations between the bladder disease diagnosed, and both patient and histologic variables. There were 102 cases of cystitis, 84 neoplasia, 42 urolithiasis and 63 normal bladders. Logistic regression modeling identified six variables that were significantly associated with disease outcome: species, urothelial ulceration, urothelial inflammation, submucosal lymphoid aggregates, neutrophilic submucosal inflammation, and moderate submucosal hemorrhage. This study demonstrated that logistic regression modeling could provide a more objective approach to veterinary histopathology and has opened the door toward predictive disease modeling based on histologic variables.

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Section: Discussionmentioning

confidence: 99%

Predicting Diagnosis of Australian Canine and Feline Urinary Bladder Disease Based on Histologic Features

Jones

Alawneh

Thompson

et al. 2020

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Urothelial ulceration was significantly associated with urolithiasis, which makes sense biologically as this disease is characterised by the presence of a urolith in the bladder lumen. The bladder stone/s causes physical trauma to urothelial cells, sometimes to the point of complete urothelial loss (180,318). Urothelial loss may also occur as a post-mortem change or as part of tissue handing during biopsy, however we endeavoured to prevent misclassification here by using separate variables for urothelial loss (denudation) and ulceration.…”

Section: Discussionmentioning

confidence: 99%

“…The histological changes observed in cases of urolithiasis in cats and dogs are secondary to the physical trauma of the uroliths and include urothelial hyperplasia, urothelial erosion and ulceration, submucosal haemorrhage, congestion and oedema as part of the inflammatory process, perivascular neutrophilic and/or lymphocytic inflammation, and the presence of mineral calculi in the bladder lumen (26,180,324,367). Necrosis of the superficial bladder wall can occur in chronic cases due to the local pressure exerted by the urolith on the bladder wall (26,367).…”

Section: Urolithiasismentioning

confidence: 99%

Pathological and clinicopathological features of canine and feline bladder disease

Jones¹

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Dogs and cats commonly present to veterinary hospitals with urinary bladder disease, but despite their clinical importance and comparative potential to human diseases, bladder diseases in Australian dogs and cats are under investigated. In veterinary pathology, insufficient levels of diagnostic agreement can occur, and this is influenced by sample quality as well as the pathologist's own experience, training, and cognitive biases. Logistic regression is a statistical technique which, when applied to veterinary histopathology, could improve pathologist agreement. Thus, there were two overarching goals of this thesis-to investigate the pathology and comparative potential of canine and feline urinary bladder disease in Australia, and to explore the utility of logistic regression modelling in improving inter-pathologist agreement. This project conducted a retrospective evaluation of pathology cases of canine and feline urinary bladder tissue from the veterinary pathology archives of the

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Urinary Bladder, Ureter, and Urethra

Cited by 2 publications

References 57 publications

Predicting Diagnosis of Australian Canine and Feline Urinary Bladder Disease Based on Histologic Features

Predicting Diagnosis of Australian Canine and Feline Urinary Bladder Disease Based on Histologic Features

Pathological and clinicopathological features of canine and feline bladder disease

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