Urinary cholesterol: its association with a macromolecular protein-lipid complex.

Jüngst, Dieter; Weiser, H.; Siess, Elmar A.; Karl, Hans Josef

doi:10.1016/s0022-2275(20)37754-3

Cited by 6 publications

(1 citation statement)

References 35 publications

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“…In cases of PHA associated with UTI, the USP classically shows very low excretion of 3β hydroxy‐5ene steroids, increase in metabolites of aldosterone and aldosterone precursors, together with increase in cholesterol. The presence of urinary cholesterol has previously been described in adult human males both in normal and disease states, as a component of membranes derived from endogenous cells of the urogenital system 13,14 . Based on the details on the reporting card, and further clinical details obtained directly from the clinician using a specific questionnaire, the study group made the decision as to whether or not a reported patient fulfilled criteria for diagnosis of PHA.…”

Section: Methodsmentioning

confidence: 99%

The incidence of transient infantile pseudohypoaldosteronism in Ireland: A prospective study

et al. 2021

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Aim To review the clinical course, outcome and incidence of infantile salt wasting associated with urinary tract infection (UTI) and/or urinary tract malformation (UTM) over a two‐year surveillance period on the island of Ireland. Methods A two‐year (2013‐14) prospective surveillance undertaken via the Irish and Ulster Paediatric Surveillance Units. Monthly prepaid postcards were circulated to consultant paediatricians (n = 260) at all paediatric units on the island of Ireland. Infants under one year of age presenting for the first time with hyponatraemia (Na < 130 mmol/L) and/or hyperkalaemia (K > 5.0 mmol/L) associated with urosepsis/UTM were reported. Results All 7 reported patients (6 male) had culture‐proven UTI, and 5 (71%) also had an underlying UTM (one diagnosed antenatally). Four (57%) patients had a documented elevated serum aldosterone supporting secondary pseudohypoaldosteronism (PHA) as the underlying diagnosis. Data on aldosterone were not reported in the other 3 patients, but clinical features were suggestive of secondary PHA. The estimated incidence for the Irish population of transient PHA is 1 per 13,200 total live births per year. Conclusions Salt wasting is a rare complication of UTI, especially if associated with underlying UTM. Boys appear to be at particular risk.

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Section: Methodsmentioning

confidence: 99%

The incidence of transient infantile pseudohypoaldosteronism in Ireland: A prospective study

et al. 2021

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Isolation and characterization of proteolipids from rat liver (LSP) and kidney (KSP)

Jüngst

Blumenstingl

Caselmann

1988

Lipids

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In this study, the biochemical characteristics of proteolipids of rat liver and kidney homogenates were compared. In all preparations, the proteo‐lipids were eluted at the void volume of the Biogel A‐15 m column after gel chromatography, and a molecular weight over 15×106 was estimated. Electron microscopy of the concentrated void volume fractions showed globular particles with diameters of 30–100 nm for liver (LSP) and 30–60 nm for kidney (KSP) preparations that might be formed from plasma membrane fragments. After ultracentrifugation in a CsCl gradient, rat LSP and KSP floated in a small density range from 1.16–1.17 g/ml. There was no significant difference between the relative percentages of phospholipids, triglycerides and cholesterol of both proteo‐lipids. However, the relative mean amount of total protein in rat KSP (60.4% vs 50.4%) was significantly higher and the content of free fatty acids (4.3% vs 12.6%) significantly lower compared to rat LSP. SDS‐PAGE revealed at least 12 protein subunits ranging from 15,000–130,000 in both preparations, but one protein of about Mr 49,000 might represent a liver specific component. The isolated proteo‐lipids from rat liver and kidney homogenates showed similar biochemical characteristics as those from human sources, which could explain the known cross‐reactivity of antibodies against these preparations.The putative function of these proteo‐lipids is not known, although there is some evidence from human studies that they carry receptor proteins.

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Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome

Jüngst

Caselmann

Kutschera

et al. 1987

Clinica Chimica Acta

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The mechanism leading to hyperlipidemia in the nephrotic syndrome is not fully understood but may be related in part to loss of high density lipoproteins in the urine of patients with nephrosis. To prove this hypothesis, we compared serum lipoprotein profiles with the excretion of high density lipoproteins in urine in 19 nephrotic patients. Serum cholesterol ranged from 19-152 (median value 45) mg/dl in very low density lipoproteins (VLDL), from 130-443 (median 186) mg/dl in low density lipoproteins (LDL) and from 19-64 (median 33) mg/dl in high density lipoproteins (HDL). Hyperlipoproteinemia was found in 17 patients, which was classified as phenotype IIa (Fredrickson) in 2, as phenotype IIb in 9 and as phenotype IV in 6 subjects. Two patients showed normal lipoprotein patterns. VLDL-and LDL-cholesterol were not found in detectable amounts in urine, whereas HDL-cholesterol was measured in low concentrations from 0.1-8.3 mg/24 h in all samples. There was no correlation between serum HDL-cholesterol and urinary HDL-cholesterol, but a positive correlation between serum LDL-cholesterol and urinary HDL-cholesterol (r = + 0.54, p < 0.05). However, the total amount of the daily urinary loss of HDL (< 1% of total plasma HDL) seems not to be sufficient to explain hyperlipoproteinemia in the nephrotic syndrome.Correspondence and reprint requests to:

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Urinary cholesterol: its association with a macromolecular protein-lipid complex.

Cited by 6 publications

References 35 publications

The incidence of transient infantile pseudohypoaldosteronism in Ireland: A prospective study

The incidence of transient infantile pseudohypoaldosteronism in Ireland: A prospective study

Isolation and characterization of proteolipids from rat liver (LSP) and kidney (KSP)

Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome

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