Urinary Collagen Crosslinks Reflect the Radiographic Severity of Knee Osteoarthritis

Thompson, P. W.; Spector, T. D.; James, Ian; Henderson, Elizabeth; Hart, Deborah

doi:10.1093/rheumatology/31.11.759

Cited by 44 publications

(25 citation statements)

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“…Kelman et al [8] recently showed increased serum levels of NTX I in an elderly female population in association with the onset of hip osteoarthritis. Similar findings were also described for the urine concentrations of DPD and CTX [2,22]. In our study we attempted to limit possible disturbing factors by creating a clear study protocol and recruiting a consistent study population.…”

Section: Discussionsupporting

confidence: 55%

Biochemical markers of bone turnover in aseptic loosening in hip arthroplasty

Streich

Gotterbarm

Jung

et al. 2007

International Orthopaedics (SICO

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The aim of this study was to determine the diagnostic value of systemic biochemical markers of bone turnover in aseptic loosening in hip arthroplasty, namely the urine levels of three bone resorption peptides -crosslinked n-telopeptides (NTX), c-telopeptides (CTX I) and deoxypyridinoline (DPD). We compared 52 patients with surgically proven component loosening with 52 patients without clinical or radiological signs of endoprosthetic loosening and 52 healthy individuals. All three markers were measured using commercially available enzyme-linked immunoassays. We found significantly increased levels of DPD in the loosening group (p<0.05), but there was no significant difference between the loosening group and the two reference groups for the other two markers tested. Our data suggest that DPD can be used as an additional tool in the diagnosis of aseptic loosening in hip arthroplasty but CTX I and NTX have no predictive value in this context. Résumé Le but de cette étude est de déterminer la valeur diagnostic de marqueurs bio-chimiques dans le descellement aseptique des prothèses totales de hanche, en mesurant un certain nombre peptides issus de la résorption osseuse (crosslinked n-telpeptides [NTX], c-telpepetides [CTX I] et deoxypyridinoline [DPD]. nous avons comparé les paramètres de 52 individus présentant un descellement aseptique à 52 individus sains. Tous les paramètres ont été mesurés par la méthode ELISA. nous avons trouvé une augmentation significative des DPD dans le groupe prothèses descellées (p<0.05). Il n'y a pas de différence significative entre les deux groupes pour les autres marqueurs. nous suggérons que la DPD peut être utilisée comme un marqueur additionnel du diagnostic des descellements aseptiques des prothèses totales de hanche par contre, il n'y a pas de valeurs prédictives pour les marqueurs CTX1 et NTX.

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Section: Discussionsupporting

confidence: 55%

Biochemical markers of bone turnover in aseptic loosening in hip arthroplasty

Streich

Gotterbarm

Jung

et al. 2007

International Orthopaedics (SICO

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“…Although bone resorption is probably the major source of urine hydroxypyridinium cross-links [13,14], the PYD/DPD ratio may help to define collagen degradation in cartilage relative to other tissues. In agreement with previous studies in OA patients [10,13], PYD and DPD were highly correlated (r = 0.75, P < 0.001), and the PYD/DPD ratio was unchanged. In patients with advanced OA, both PYD and DPD were significantly increased and the PYD/DPD ratio was also unchanged.…”

Section: Discussionsupporting

confidence: 92%

“…Our number of normal controls is rather higher than that of previous studies, in some of which the same control group was used repeatedly [11,12,15]. Means and standard deviations of the present normal control group were also close to those of previous studies in which the same HPLC method was used [10,19]. There were more women and old patients in our OA group than in the control group.…”

Section: Discussionsupporting

confidence: 73%

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Assessment of Urinary Hydroxypyridinium Cross-Links Measurement in Osteoarthritis

Graverand¹,

Tron²,

Ichou³

et al. 1995

Rheumatology

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SUMMARYThe aim of this study is to re-evaluate urinary collagen cross-links, previously proposed as markers of osteoarthritis (OA). The urinary excretion of collagen cross-links, pyridinoline (PYD) and deoxypyridinoline (DPD), was measured using high-performance liquid chromatography (HPLC) in 114 patients with OA, 19 patients with rheumatoid arthritis (RA) and 40 healthy subjects. An increase in PYD and DPD, expressed per millimole of creatinine, was confirmed in RA. However, PYD and DPD in patients with hip OA, knee OA and polyOA were similar, and did not differ from controls. In patients with radiographic end-stage OA, PYD and DPD were significantly higher than in patients with an early OA, but not significantly higher than in controls. The PYD/DPD ratio did not vary with the OA stage. Thus, urinary collagen cross-links are not elevated in OA, but could reflect bone sclerosis and/or erosion in late OA.

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“…However, they suggested that increased urinary crosslinks may primarily originate from bone rather than cartilage. Tompson et al [23] have found urinary collagen crosslinks to be a weak marker of severity of knee OA. On the other hand, Astbury et al [24] and Graverand et al [25] have found no significant difference between OA patients and normals in urinary excretion of pyridinium crosslinks.…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density and Bone Turnover in Patients with Knee Osteoarthritis Compared with Generalized Osteoarthritis

et al. 2000

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The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the lumber spine, femur, and radius, and biochemical markers of bone turnover, pyridinoline (Pyr), deoxypyridinoline (Dpyr), CTx, and osteocalcin were compared among each grade. BMD was also compared with 88 normal controls who were age and weight-matched. In 88 KOA patients, 56 were divided into 28 GOA and 28 non-GOA groups by grading hand radiographs. BMD and biochemical markers were compared between GOA and non-GOA. KOA patients had higher BMD at several skeletal sites compared with age- and weight-matched normals. A significant difference of BMD between each grade was observed between grades 0-1 and 3 (0.774+/-0.143 versus 0.940+/-0.185 g/cm(2), P<0.001), grades 2 and 3 (0.781+/-0.125 versus 0.940+/-0.185 g/cm(2), P<0.01) in the spine, and between grades 0-1 and 3 (0.505+/-0.100 versus 0.564+/-0.127 g/cm(2), P<0.05) in the trochanter. A significant difference of biochemical bone markers was observed between grades 0-1 and 3 (P<0.05) and between grades 2 and 3 (P<0.05) in Pyr and grades 0-1 and 3 (P<0.05) and between grades 1 and 4 (P<0.05) in Dpyr, but not in osteocalcin and CTx. GOA patients had higher BMD of the spine (0.902+/-0.175 versus 0.747+/-0.138 g/cm(2), P<0.01), trochanter (0.535+/-0.107 versus 0.480+/-0.107 g/cm(2), P<0.05), and one-third of the radius (0.526+/-0.068 versus 0.472+/-0. 089 g/cm(2), P<0.05) and had significantly higher biochemical markers in Pyr and Dpyr than non-GOA patients. It is concluded that KOA patients had higher BMD at several skeletal sites. Biochemical bone markers were influenced by some degree of cartilage damage in OA patients. This tendency was stronger in GOA patients than in non-GOA patients.

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Urinary Collagen Crosslinks Reflect the Radiographic Severity of Knee Osteoarthritis

Cited by 44 publications

References 0 publications

Biochemical markers of bone turnover in aseptic loosening in hip arthroplasty

Biochemical markers of bone turnover in aseptic loosening in hip arthroplasty

Assessment of Urinary Hydroxypyridinium Cross-Links Measurement in Osteoarthritis

Bone Mineral Density and Bone Turnover in Patients with Knee Osteoarthritis Compared with Generalized Osteoarthritis

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