Urinary concentrations of bisphenol A and its alternatives: Potential predictors of and associations with antral follicle count among women from an infertility clinic in Northern China

Zhang, Ningxin; Zhao, Yannan; Zhai, Lingling; Bai, Yinglong; Wei, Wei; Sun, Qi; Jia, Lihong

doi:10.1016/j.envres.2024.118433

Environmental Research

2024

DOI: 10.1016/j.envres.2024.118433

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Urinary concentrations of bisphenol A and its alternatives: Potential predictors of and associations with antral follicle count among women from an infertility clinic in Northern China

Ningxin Zhang,

Yannan Zhao,

Lingling Zhai

et al.

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Cited by 3 publications

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Assessment of bisphenol accumulation from disposable devices used sequentially in IVF routine procedures

Delaroche,

Besnard,

Cassuto

et al. 2025

Reproductive BioMedicine Online

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Assessment of bisphenol accumulation from disposable devices used sequentially in IVF routine procedures

Delaroche,

Besnard,

Cassuto

et al. 2025

Reproductive BioMedicine Online

View full text Add to dashboard Cite

Correlation of bisphenol A and bisphenol S exposure with the metabolic parameters on FDG PET/CT image

Xiao,

Wen,

et al. 2024

Front. Public Health

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PurposeBisphenol A (BPA) and its analogs have been proved to be harmful to human health. This study aimed to assess the correlation of BPA and its major analog, Bisphenol S (BPS), with metabolic parameters within main organs using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging.MethodsA retrospective analysis was conducted on patients who had undergone FDG PET/CT imaging and were also examined for BPA and BPS levels. Urine samples were collected for detection of BPA and BPS. Standardized uptake values (SUVmax and SUVmean) of main organ tissues including liver, blood, spleen, muscle, thyroid, and cerebral cortex were quantified. Statistical analysis was performed using Spearman’s rank correlation.ResultsForty patients (20 female, 20 male; mean age: 56.1 ± 15.4 years) were included. Mean urine BPA and BPS concentrations were 2.1 ± 1.2 ng/mL and 1 ± 0.6 ng/mL, respectively. Urine BPA exhibited a moderate positive correlation with liver SUVmax (r = 0.351, p = 0.026) and SUVmean (r = 0.361, p = 0.022) in male. No significant correlations were found between BPA and blood, muscle, spleen, thyroid, and cerebral cortex (p > 0.05). Conversely, urine BPS demonstrated a negative correlation with thyroid SUVmax in male (r = −0.43, p = 0.012) and SUVmean (r = −0.432, p = 0.012), while a positive correlation was observed between BPS and cerebral cortex SUVmax in female (r = 0.366, p = 0.033).ConclusionUrinary levels of BPA and BPS exerted distinct influences on tissue metabolic parameters observed via FDG PET/CT imaging, particularly affecting the liver, thyroid, and cerebral cortex.

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The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review

Drakaki,

Stavros,

Dedousi

et al. 2024

JCM

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Bisphenols, particularly bisphenol A (BPA), are among the most thoroughly investigated endocrine disrupting chemicals (EDCs). BPA was the first synthetic estrogen to be identified, exerting its estrogenic effects through interaction with human estrogen receptors (ERs). The aim of the present narrative review is to summarize the most recent literature regarding the adverse effects of bisphenols on female fertility and pregnancy outcomes. A review of the literature in the PubMed/Medline and Scopus databases was conducted in November 2024 and 15 studies were included in the present review. BPA levels were higher in women with diminished ovarian reserve, polycystic ovary syndrome, and recurrent miscarriages. Furthermore, one study showed a significant association between BPA levels and the onset of gestational diabetes mellitus. Higher levels of BPA are associated with disruptions to the female reproductive system, such as ovarian function, reduced number of antral follicles, and lower anti-Müllerian hormone (AMH) levels. Bisphenols A and S were associated with an increased risk of developing gestational diabetes mellitus. Bisphenols A and F were correlated with an increased risk of lower birth weight and bisphenol F seemed to be associated with an increased risk of preterm delivery. Ultimately, further research is necessary to fully understand the extent of the harmful effects that bisphenols have separately and as mixtures on the female reproductive system.

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Urinary concentrations of bisphenol A and its alternatives: Potential predictors of and associations with antral follicle count among women from an infertility clinic in Northern China

Cited by 3 publications

References 48 publications

Assessment of bisphenol accumulation from disposable devices used sequentially in IVF routine procedures

Assessment of bisphenol accumulation from disposable devices used sequentially in IVF routine procedures

Correlation of bisphenol A and bisphenol S exposure with the metabolic parameters on FDG PET/CT image

The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review

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