Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel

Machtinger, Ronit; Berman, Tamar; Adir, Michal; Mansur, Abdallah; Baccarelli, Andrea A.; Racowsky, Catherine; Calafat, Antònia M.; Hauser, Russ; Nahum, Ravit

doi:10.1016/j.envint.2018.04.022

Cited by 59 publications

(28 citation statements)

References 44 publications

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“…For example median mEHHP (

), mEOHP (

), mBP (

), and BPA (

) concentrations in the present study were similar to those estimated in Canada (9, 6, 12, and

, respectively) ( Arbuckle et al. 2014 ) and Israel (6, 5, 10, and

, respectively) ( Machtinger et al. 2018 ).…”

Section: Discussionsupporting

confidence: 88%

Phthalate and Bisphenol Exposure during Pregnancy and Offspring Nonverbal IQ

Dries

Guxens

Spaan³

et al. 2020

Environ Health Perspect

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Background: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the third trimester. Objective: We examined the association between pregnancy maternal urinary biomarkers of phthalate or bisphenol exposure and nonverbal intelligence quotient (IQ) in children 6 years of age. Method: The study sample consisted of 1,282 mother–child pairs participating in the Generation R Study, a population-based birth cohort in Rotterdam, Netherlands (enrollment 2002–2006). We measured maternal urinary concentrations of 18 phthalate metabolites and 8 bisphenols at , 18–25, and of gestation. Child nonverbal IQ was measured at 6 years of age using the Snijders-Oomen Nonverbal Intelligence Test–Revised. Linear regression models were fit for each of the three collection phases separately, the three collection phases jointly, and for the averaged prenatal exposure across pregnancy. Results: Higher urinary concentrations of phthalate metabolites during early pregnancy were associated with lower child nonverbal IQ score [e.g., B per 10-fold increase in summed low-molecular (95% CI: , )]. This association remained unchanged when adjusted for mid and late pregnancy exposures. We also observed an inverse association between late pregnancy di- n -octyl phthalate (DNOP) exposure and nonverbal IQ. Maternal urinary concentrations of bisphenols were not associated with child nonverbal IQ. There was no effect estimate modification by sex. Conclusions: We did not observe that maternal biomarkers of bisphenol exposure are associated with nonverbal IQ. We found that phthalate exposure in early pregnancy and DNOP exposure in late pregnancy are associated with lower nonverbal IQ scores in children. Our results might suggest that particularly early pregnancy is a sensitive window of phthalate exposure, but future studies are needed to replicate our findings. https://doi.org/10.1289/EHP6047

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“…For example median mEHHP (

), mEOHP (

), mBP (

), and BPA (

) concentrations in the present study were similar to those estimated in Canada (9, 6, 12, and

, respectively) ( Arbuckle et al. 2014 ) and Israel (6, 5, 10, and

, respectively) ( Machtinger et al. 2018 ).…”

Section: Discussionsupporting

confidence: 88%

Phthalate and Bisphenol Exposure during Pregnancy and Offspring Nonverbal IQ

Dries

Guxens

Spaan³

et al. 2020

Environ Health Perspect

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“…Samples were collected between July 2015 and July 2019 from women with dichorionic diamniotic (DC/DA) twin pregnancies as diagnosed by early foetal ultrasound and their newborns that were delivered by caesarean section in a tertiary university‐affiliated hospital. This cohort was drawn from a larger study designed to evaluate associations between prenatal exposure to endocrine‐disrupting chemicals (EDCs) and epigenetic alterations in twin pregnancies 17 . Venous cord blood serum samples were collected during caesarean sections, aliquoted and stored at −80°C.…”

Section: Methodsmentioning

confidence: 99%

“…This cohort was drawn from a larger study designed to evaluate associations between prenatal exposure to endocrine-disrupting chemicals (EDCs) and epigenetic alterations in twin pregnancies. 17 Venous cord blood serum samples were collected during caesarean sections, aliquoted and stored at −80°C.…”

Section: Patients and Sample Collectionmentioning

confidence: 99%

Cord blood androgen levels of females from same sex and opposite sex twins – A pilot study

Galiano

Solazzo

Rabinovici

et al. 2020

Clinical Endocrinology

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Objective: Opposite-sex twins have shown behavioural and reproductive differences between females and males. These differences may be determined by higher intrauterine levels of androgens among females that were exposed to a male co-twin. The aim of this study was to compare cord blood androgen levels in females from samesex and opposite-sex twins. Design: A prospective study. In this pilot study, we compared cord blood androgens (DHEA-S, Δ-4 androstenedione, total testosterone-TT) and sex hormone-binding globulin (SHBG) levels in 20 females from same sex and 20 females from opposite-sex dichorionic diamniotic twins. We used generalized estimating equation (GEE) modelling to assess differences in cord blood androgens between females from same-sex twin pregnancies and females from opposite-sex twin pregnancies. Patients: Twenty opposite-sex twin pairs (female-male twins) and 20 same-sex twin pairs (female-female). Measurements: Cord blood total testosterone, Δ-4 androstenedione, DHEA-S and sex hormone-binding globulin (SHBG) levels. Results: No difference in the levels of androgens as Δ-4 androstenedione, total testosterone and SHBG was identified between females that were exposed to a female co-twin compared with females that were exposed to a male co-twin. DHEA-S levels were significantly lower among females from opposite-sex twins compared with females from same-sex twins. Conclusions: Our preliminary data do not support the hypothesis that females exposed to male co-twins are exposed to higher levels of androgens in utero compared with females exposed to female co-twins. Further studies are needed to explain the reported behavioural and reproductive differences among opposite-sex twins. K E Y W O R D S androgens, cord blood hormones, females, intrauterine environment, opposite-sex twins, same-sex twins, testosterone transfer theory How to cite this article: Galiano V, Solazzo G, Rabinovici J, et al. Cord blood androgen levels of females from same sex and opposite sex twins-A pilot study. Clin Endocrinol (Oxf).

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“…44 Ayrıca, 50 gebe kadın arasında yapılan bir çalışmada, kişisel bakım ürünleri maruziyeti ile ftalat ve BPA gibi kimyasallar için idrarda biyogösterge tayini gerçekleştirilmiştir. 45 İncelenen biyogöstergelerin yaklaşık yarısı (1,2-sikloheksan dikarboksilik asit, diizononil ester, bisfenol S ve bisfenol F vb.) kadınların %90'ında saptanmıştır.…”

Section: Ftalatlarunclassified

“…kadınların %90'ında saptanmıştır. 45 Başka bir çalışmada, kişisel bakım ürünü kullanan ergenliğe girmiş 100 genç kadın arasında; ftalat, paraben, triklosan ve benzofenon-3'ün üriner metabolitleri arasındaki ilişki değerlendirilmiştir. 46 Kullanılan kişisel bakım ürününe göre idrarda rastlanılan üriner metabolit konsantrasyonu da yüksek çıkmıştır.…”

Section: Ftalatlarunclassified

Toxicity of Cosmetic Products: Endocrine Disruptor Chemicals

Karaman¹,

Özden²

2019

J Lit Pharm Sci

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Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel

Cited by 59 publications

References 44 publications

Phthalate and Bisphenol Exposure during Pregnancy and Offspring Nonverbal IQ

Phthalate and Bisphenol Exposure during Pregnancy and Offspring Nonverbal IQ

Cord blood androgen levels of females from same sex and opposite sex twins – A pilot study

Toxicity of Cosmetic Products: Endocrine Disruptor Chemicals

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