Urinary detection of toscana virus nucleic acids in neuroinvasive infections

Ergünay, Koray; Kaplan, Berkan; Okar, Serhat; Akkutay-Yoldar, Zeynep; Kurne, Aslı; Arsava, Ethem Murat; Özkul, Aykut

doi:10.1016/j.jcv.2015.07.297

Cited by 18 publications

(21 citation statements)

References 10 publications

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“…Of note is the demonstration of TOSV and West Nile virus coinfections, presenting as febrile disease in 2 young adults from eastern Thrace . Recently, TOSV RNA was identified in urine in a group of acutely infected individuals, and testing of urine for viral nucleic acids was considered as a supplementary approach for diagnosis …”

Section: Resultsmentioning

confidence: 92%

“…Cases with febrile disease with/without neurological symptoms due to TOSV have been repeatedly identified via viral RNA detection in various regions of Anatolia since the description of initial cases in 2010. Moreover, serologically proven infections with the detection of specific IgM antibodies in serum or CSF followed by viral neutralization test were also reported .…”

Section: Resultsmentioning

confidence: 95%

“…While TOSV genotype A sequences have repeatedly been characterized in Central Anatolia and also in Eastern Thrace, cocirculation of genotypes A and B has been revealed in animal specimens from Mersin to Adana provinces of Mediterranean Anatolia . A total of 12 TOSV sequences of human and animal origin were accessed in GenBank.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, no vertebrate species have been listed as phlebovirus reservoirs or amplifying hosts, and the vectors have been considered to contribute to viral perpetuation via transovarial and venereal routes . Other significant findings are the detection of symptomatic TOSV coinfections in young adults from eastern Thrace and viral RNA in urine of the affected individuals from Central Anatolia, which is a good indicator of a TOSV diagnosis.…”

Section: Discussionmentioning

confidence: 97%

“…Exposure to the members of the SFNV species has also been revealed in Asia Minor. Serological screening in various cohorts of asymptomatic residents/blood donors has also provided evidence for ongoing TOSV exposure via neutralization assays throughout Anatolia and eastern Thrace . Interestingly, serosurveillance studies undertaken 60 and 35 years ago revealed SFNV activity in residents of Aegean and Mediterranean Anatolia .…”

Section: Discussionmentioning

confidence: 99%

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Novel and emergent sandfly‐borne phleboviruses in Asia Minor: a systematic review

Ergünay

Ayhan

Charrel

2016

Reviews in Medical Virology

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Sandfly-transmitted phleboviruses are globally spread agents causing febrile diseases and central nervous system infections. The activity of pathogenic phleboviruses, as well as several novel strains, has been reported from Turkey, a transboundary country connecting Asia, Europe, and Africa with suitable habitats for sandflies. This study overviews all published data on phleboviruses from Turkey and evaluates the impact from the virological, epidemiological, and public health perspectives. A systematic review of Web-based global and local resources was performed. Comparison and phylogenetic analyses of particular phlebovirus sequences were also undertaken. Through the evaluation of 1693 international and regional entries, 31 manuscripts providing data on case reports or outbreaks, serological surveillance, animal infections and exposure, virus characterization, vector surveillance, and/or diagnostics were accessed. Detailed information on 5 novel phleboviruses completely or partially characterized during 2008-2015 as well as on clinical and epidemiological features of major phleboviruses established as human pathogens such as Toscana virus and sandfly fever Sicilian virus has been compiled. The ongoing activity of these agents, as indicated by consistently reported symptomatic cases and confirmed exposure in vertebrates including humans, was noted. The circulation in the Anatolian peninsula of phleboviruses with surprising diversity as well as distinct virus species is documented. Specific phlebovirus strains constitute a public health threat for local populations and travelers and must be considered in the diagnostic workup of clinically compatible cases. Human health impact and epidemiological aspects of certain viruses require further investigation via intensive surveillance.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Novel and emergent sandfly‐borne phleboviruses in Asia Minor: a systematic review

Ergünay

Ayhan

Charrel

2016

Reviews in Medical Virology

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Detection of Toscana virus from an adult traveler returning to Australia with encephalitis

Arden

Heney²,

Shaban

et al. 2017

Journal of Medical Virology

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Toscana virus (TOSV) is identified in sandflies, animals, and humans around the Mediterranean Sea. TOSV has not been reported in Australia. During investigations of cerebrospinal fluid samples from patients with encephalitis, TOSV genetic sequences were identified in a traveler returning to Australia from Europe. TOSV should be considered, especially during May to October, in travelers to Australia who embarked in countries in and around the Mediterranean Sea and who subsequently present for medical care because of neurological symptoms.

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Sandmückenfieber – eine „vernachlässigte“ Krankheit

et al. 2018

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A 45-year-old woman presented at the outpatient department of a center for tropical diseases with fever, diarrhea, headache, myalgia, malaise, and an itchy papular rash. She had been on holiday with her family for 11 days in a mountain village in northern Cyprus. The place was infested with a lot of small, stinging flies or mosquitoes. She and her family became sick after they returned home. The physical examination was normal apart from the rash on the inside of the extremities. Significantly elevated transaminases and a slightly increased C‑reactive protein level were found in the blood examination. Considering the country of travel, the report of the "stinging flies" and the clinical presentation, sandfly fever was also taken into account as a differential diagnosis for the hepatitis. Antibodies to the sandfly fever Sicilian virus (SFSV) were detected. They showed the typical dynamics during the course of the illness and thus "pappataci fever" was diagnosed. The case report and a short review of up-to-date literature is meant encourage consideration of phlebovirus infection as a possible differential diagnosis in travelers or refugees suffering from severe febrile hepatitis and rash or aseptic viral meningitis after their stay in the Mediterranean area.

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Urinary detection of toscana virus nucleic acids in neuroinvasive infections

Cited by 18 publications

References 10 publications

Novel and emergent sandfly‐borne phleboviruses in Asia Minor: a systematic review

Novel and emergent sandfly‐borne phleboviruses in Asia Minor: a systematic review

Detection of Toscana virus from an adult traveler returning to Australia with encephalitis

Sandmückenfieber – eine „vernachlässigte“ Krankheit

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