Urinary enterolactone associated with liver enzyme levels in US adults: National Health and Nutrition Examination Survey (NHANES)

Xu, Cheng; Liu, Qian; Zhang, Qunwei; Jiang, Zhaoyan; Gu, Aihua

doi:10.1017/s000711451500149x

Cited by 14 publications

(13 citation statements)

References 42 publications

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“…Metabolites may also be associated with signaling pathways related to the development of cancer, and therefore can serve as predictors of disease. 24 Enterolignans, which eventually undergo enterohepatic circulation, may affect metabolic pathways by regulating sterol transporters 25 , steroid hormones and their receptors 26, 27 , and liver enzymes 28 . Hence, it is possible that enterolignans alter plasma metabolite abundances as a result of their activity on various tissues.…”

Section: Introductionmentioning

confidence: 99%

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets

et al. 2017

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Enterolignans, products of gut bacterial metabolism of plant lignans, have been associated with reduced risk of chronic diseases, but their association with other plasma metabolites is unknown. We examined plasma metabolite profiles according to urinary enterolignan excretion in a cross-sectional analysis using data from a randomized crossover, controlled feeding study. Eighty healthy adult males and females completed two 28-day feeding periods differing by glycemic load, refined carbohydrate, and fiber content. Lignan intake was calculated from food records using a polyphenol database. Targeted metabolomics was performed by LC-MS on plasma from fasting blood samples collected at the end of each feeding period. Enterolactone (ENL) and enterodiol (END), were measured in 24-h urine samples collected on the penultimate day of each study period using GC-MS. Linear mixed models were used to test the association between enterolignan excretion and metabolite abundances. Pathway analyses were conducted using the Global Test. Benjamini-Hochberg false discovery rate (FDR) was used to control for multiple testing. Of the metabolites assayed, 121 were detected in all samples. ENL excretion was associated positively with plasma hippuric acid and melatonin, and inversely with epinephrine, creatine, glycochenodeoxycholate, and glyceraldehyde (P <0.05). Hippuric acid only satisfied the FDR of q < 0.1. END excretion was associated with myristic acid and glycine (q <0.5). Two of 57 pathways tested were associated significantly with ENL, ubiquinone and terpenoid-quinone biosynthesis, and inositol phosphate metabolism. These results suggest a potential role for ENL or ENL-metabolizing gut bacteria in regulating plasma metabolites.

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Section: Introductionmentioning

confidence: 99%

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets

et al. 2017

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“…In the last 5 years, additional observational studies looking at urinary enterolactone or enterodiol have been published using NHANES data, which is a nationally representative sample of the U.S. population. Studies evaluated different classifications of urinary enterolignans and populations . The results from NHANES studies support that urinary enterolactone and enterodiol are associated with more favorable cardiometabolic risk factors, including BMI, abdominal obesity, triglycerides, HDL cholesterol, blood pressure, and inflammation, and that associations appear stronger for enterolactone.…”

Section: Other Phytoestrogensmentioning

confidence: 86%

Section: Other Phytoestrogensmentioning

confidence: 99%

Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes

Frankenfeld

2016

Molecular Nutrition Food Res

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Recent evidence supports that the gut microbial community, independently and/or interactively with dietary intake, is a target for reducing cardiovascular disease risk through its effects on cardiometabolic risk factors. Dietary phytoestrogens may be a source for interactive effects. Phytoestrogens, such as isoflavones, lignans, and flavonoids, are compounds found in plants that have estrogenic or antiestrogenic activities, as well as antioxidant, antiproliferative, or apoptotic actions. Given these physiological activities, phytoestrogens may have a role in cardiometabolic health. Some phytoestrogens consumed in the diet undergo biotransformation through gut bacterial metabolism to other compounds that may exhibit similar or different physiological activity than the parent compound. There is interindividual variability in the capability to metabolize phytoestrogens to their metabolites, and there is a resulting phenotype that can be evaluated based on urinary metabolite excretion. Evidence suggests that phytoestrogen metabolites and/or phenotypes are associated with cardiometabolic risk factors, such as blood pressure, abdominal obesity, and serum lipids, triglycerides, glucose, and inflammatory markers. The objective of this review was to provide an overview of the observed associations between gut microbial phytoestrogen metabolites and metabolite phenotypes with cardiometabolic risk factors, with focus on the more extensively studied isoflavone metabolites.

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“…Decreased urinary enterolactone concentrations as observed in high ultra-processed food consumers may have serious health consequences if, as was shown in a study carried out with US NHANES 2003–2010 survey, urinary enterolactone concentrations are inversely associated with serum g-glutamyl transaminase (GGT) levels in adult males and females, with alkaline phosphatase (ALP) in females, and with aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in adult males as well [63]. Also, another study carried with US NHANES 2001–2010, found an inverse association between urinary enterolactone levels and obesity, waist circumference, serum triacylglycerols (TAG) levels, fasting glucose levels, fasting insulin levels and metabolic syndrome in adult males, and a direct association with high-density lipoprotein HDL-cholesterol levels [64].…”

Section: Discussionmentioning

confidence: 99%

Association between Dietary Share of Ultra-Processed Foods and Urinary Concentrations of Phytoestrogens in the US

Steele

2017

Nutrients

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The aim of this study was to examine the relationship between dietary contribution of ultra-processed foods and urinary phytoestrogen concentrations in the US. Participants from cross-sectional 2009–2010 National Health and Nutrition Examination Survey aged 6+ years, selected to measure urinary phytoestrogens and with one 24-h dietary recall were evaluated (2692 participants). Food items were classified according to NOVA (a name, not an acronym), a four-group food classification based on the extent and purpose of industrial food processing. Ultra-processed foods are formulations manufactured using several ingredients and a series of processes (hence “ultra-processed”). Most of their ingredients are lower-cost industrial sources of dietary energy and nutrients, with additives used for the purpose of imitating sensorial qualities of minimally processed foods or of culinary preparations of these foods. Studied phytoestrogens included lignans (enterolactone and enterodiol) and isoflavones (genistein, daidzein, O-desmethylangolensin and equol). Gaussian regression was used to compare average urinary phytoestrogen concentrations (normalized by creatinine) across quintiles of energy share of ultra-processed foods. Models incorporated survey sample weights and were adjusted for age, sex, race/ethnicity, family income, and education, among other factors. Adjusted enterodiol geometric means decreased monotonically from 60.6 in the lowest quintile to 35.1 µg/g creatinine in the highest, while adjusted enterolactone geometric means dropped from 281.1 to 200.1 across the same quintiles, respectively. No significant linear trend was observed in the association between these quintiles and isoflavone concentrations. This finding reinforces the existing evidence regarding the negative impact of ultra-processed food consumption on the overall quality of the diet and expands it to include non-nutrients such as lignans.

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Urinary enterolactone associated with liver enzyme levels in US adults: National Health and Nutrition Examination Survey (NHANES)

Cited by 14 publications

References 42 publications

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets

Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes

Association between Dietary Share of Ultra-Processed Foods and Urinary Concentrations of Phytoestrogens in the US

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