Urinary enterolactone is associated with plasma proteins related to immunity and cancer development in healthy participants on controlled diets

Miles, Fayth L.; Navarro, Sandi L.; Garrison, Carly B.; Randolph, Timothy W.; Zhang, Yuzheng; Shojaie, Ali; Kratz, Mario; Hullar, Meredith A.J.; Raftery, Daniel; Neuhouser, Marian L.; Lampe, Paul D.; Lampe, Johanna W.

doi:10.1016/j.hnm.2021.200128

Cited by 4 publications

(2 citation statements)

References 93 publications

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“…ED and EL are phytoestrogens that are thought to have protective effects in postmenopausal breast cancer, altering proliferation and apoptotic biomarkers as well as c-erbB2 expression in a clinical trial ( 10 ). Urinary EL has been inversely associated with proteins involved in pro-proliferative and apoptotic pathways, such as the PI3k-Akt pathway ( 11 ). Interestingly, we found that microbiota metabolic activity, including that of non-lignan metabolizers, is important for lignan processing ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk

Wu,

Thompson,

Comelli

2024

Microbiol Spectr

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The gut microbial ecosystem underlies physiological relationships between the gut and distal organs. Mechanisms remain elusive but rely at least partially on the production of a diverse set of absorbable metabolites and host gene expression regulation. Here we show that in female mice, gut cecal microbiota profiles are related to microRNAs (miRNAs) expressed in the mammary gland. A subset of these miRNAs were found to regulate genes involved in breast cancer-related processes, such as cell proliferation and migration. To determine if these relationships could be exploited toward the reduction of breast cancer risk, we studied if they are modifiable by dietary flaxseed (FS), a source of lignan secoisolariciresinol diglucoside (SDG) and alpha-linolenic acid (ALA)-rich oil (FSO), both with antitumor effects. Importantly, SDG, but not ALA, needs microbial processing to release bioactive metabolites. We found that the microbiota and mammary gland miRNA are related, and FS modifies these relationships toward an antioncogenic phenotype. FSO- and SDG-related miRNAs were found to be involved in different pathways and neither FSO nor SDG alone could recapitulate the effects of whole FS, affecting unique pathways related to extracellular matrix processing. These findings highlight the existence of inter-organ microbiota-miRNA relationships, show that dietary interventions interact to affect them, and suggest a novel route for breast cancer prevention. IMPORTANCE Breast cancer is a leading cause of cancer mortality worldwide. There is a growing interest in using dietary approaches, including flaxseed (FS) and its oil and lignan components, to mitigate breast cancer risk. Importantly, there is recognition that pubertal processes and lifestyle, including diet, are important for breast health throughout life. Mechanisms remain incompletely understood. Our research uncovers a link between mammary gland miRNA expression and the gut microbiota in young female mice. We found that this relationship is modifiable via a dietary intervention. Using data from The Cancer Genome Atlas, we also show that the expression of miRNAs involved in these relationships is altered in breast cancer in humans. These findings highlight a role for the gut microbiome as a modulator, and thus a target, of interventions aiming at reducing breast cancer risk. They also provide foundational knowledge to explore the effects of early life interventions and mechanisms programming breast health.

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Section: Introductionmentioning

confidence: 99%

Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk

Wu,

Thompson,

Comelli

2024

Microbiol Spectr

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“…These biomacromolecules also meet requirements such as excellent binding capacity with various bioactive molecules, prolonged blood circulation time, and targeting ability [ 9 ]. Furthermore, proteins are naturally digested by in vivo enzymes, generating non-toxic metabolites that are readily assimilated by the body [ 10 ], and perform biological functions such as muscle maintenance [ 11 ], control of immune responses [ 12 ], cell signaling [ 13 ], and repair of damaged cells [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Plant Protein-Based Delivery Systems: An Emerging Approach for Increasing the Efficacy of Lipophilic Bioactive Compounds

Gomes

Sobral

2021

Molecules

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The development of plant protein-based delivery systems to protect and control lipophilic bioactive compound delivery (such as vitamins, polyphenols, carotenoids, polyunsaturated fatty acids) has increased interest in food, nutraceutical, and pharmaceutical fields. The quite significant ascension of plant proteins from legumes, oil/edible seeds, nuts, tuber, and cereals is motivated by their eco-friendly, sustainable, and healthy profile compared with other sources. However, many challenges need to be overcome before their widespread use as raw material for carriers. Thus, modification approaches have been used to improve their techno-functionality and address their limitations, aiming to produce a new generation of plant-based carriers (hydrogels, emulsions, self-assembled structures, films). This paper addresses the advantages and challenges of using plant proteins and the effects of modification methods on their nutritional quality, bioactivity, and techno-functionalities. Furthermore, we review the recent progress in designing plant protein-based delivery systems, their main applications as carriers for lipophilic bioactive compounds, and the contribution of protein-bioactive compound interactions to the dynamics and structure of delivery systems. Expressive advances have been made in the plant protein area; however, new extraction/purification technologies and protein sources need to be found Their functional properties must also be deeply studied for the rational development of effective delivery platforms.

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Enterolignans: from natural origins to cardiometabolic significance, including chemistry, dietary sources, bioavailability, and activity

Laveriano-Santos,

Luque-Corredera,

Trius-Soler

et al. 2024

Critical Reviews in Food Science and Nutrition

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Urinary enterolactone is associated with plasma proteins related to immunity and cancer development in healthy participants on controlled diets

Cited by 4 publications

References 93 publications

Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk

Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk

Plant Protein-Based Delivery Systems: An Emerging Approach for Increasing the Efficacy of Lipophilic Bioactive Compounds

Enterolignans: from natural origins to cardiometabolic significance, including chemistry, dietary sources, bioavailability, and activity

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