Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity

Gotō, Tomoko; Morioka, Junichiro; Inamura, Hiroaki; Yano, Megumi; Kodaira, Kazumi; Igarashi, Yasushi; Abe, Shyuzo; Kurosawa, Motohiro

doi:10.2332/allergolint.o-07-489

Cited by 26 publications

(24 citation statements)

References 29 publications

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“…The obvious advantage of non-invasiveness with urinary proteomics is tempered by the increased variability arising due to intra-individual and inter-individual changes in urine volume, pH, and other urine constituents [31,32]. The approach of creatinine correction for urine levels of biomarkers is routinely used in urine proteomics [33][34][35] and it was considered valid for studies involving measurement of urine chemokines that are believed to be passively released into urine from urothelium during the storage phase of micturition. Since passive secretion of chemokines from the bladder to the stored urine is independent of the urine flow rate downstream of kidney, creatinine adjustment together with volume of urine voided at the time of collection could be a suitable alternative method for correcting the dilution status of urine.…”

Section: Discussionmentioning

confidence: 99%

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

et al. 2009

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“…In addition, granular proteins can be identified in the blood and urine of AD patients, and they usually correlate with disease activity [126][127][128][129]. Eosinophil-specific granule proteins, including MBP, ECP, and EDN/EPX, are elevated in the peripheral blood of most AD patients and appear to correlate with disease activity [115].…”

Section: Eosinophilia In Admentioning

confidence: 97%

“…Studies have shown the successful use of serum ECP [130], MBP [131], and EDN [132] as sensitive measures for monitoring disease activity in AD. Furthermore, the urine concentration of EDN/EPX has been shown to be an indirect measure of inflammatory activity in AD [127][128][129]133]. More specific studies have shown that levels of serum EDN are even Fig.…”

Section: Eosinophilia In Admentioning

confidence: 98%

IgE, Mast Cells, and Eosinophils in Atopic Dermatitis

Liu

Goodarzi

Chen

2011

Clinic Rev Allerg Immunol

395

307

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Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in AD lesions and the association between mast cell activation and AD. It is further suggested by their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils.

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“…Despite this, ECP remains the eosinophil degranulation protein used most widely in clinical practice15). As a monitoring tool, EDN has had good results10,11,16,17). In Taniuchi et al's study11) involving atopic dermatitis patients, the serum EDN levels in mild, moderate, and severe groups were significantly higher than that in the control group ( P <0.01, P <0.05, and P <0.05, respectively).…”

Section: Eosinophil Degranulation Proteinsmentioning

confidence: 99%

Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma

Kim

2013

Korean J Pediatr

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Asthma is associated with increased levels of eosinophils in tissues, body fluids, and bone marrow. Elevated levels of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) have been noted in asthma patients. Higher levels of EDN and ECP are also associated with exacerbated asthmatic conditions. Thus, EDN, along with ECP, may aid the diagnosis and monitoring of asthma. Several groups have suggested that EDN is more useful than ECP in evaluating disease severity. This may partially be because of the recoverability of EDN (not sticky, 100% recovery rate), as ECP is a sticky and more highly charged protein. In terms of clinical utility, EDN level is a more accurate biomarker than ECP when analyzing the underlying pathophysiology of asthma. As a monitoring tool, EDN has shown good results in children with asthma as well as other allergic diseases. In children too young to fully participate in lung function tests, EDN levels may be useful as an alter native measurement of eosinophilic inflammation. EDN can also be used in adult patients and in multiple specimen types (e.g., serum, sputum, bronchoalveolar lavage fluid, and nasal lavage fluid). These results are repeatable and reproducible. In conclusion, EDN may be a novel biomarker for the diagnosis, treatment, and monitoring of asthma/allergic disease.

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Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity

Abstract: The urinary EDN concentration in patients with atopic dermatitis is a useful clinical marker for monitoring disease activity.

Cited by 26 publications

References 29 publications

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

IgE, Mast Cells, and Eosinophils in Atopic Dermatitis

Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma

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