Urinary excretion of calcium, magnesium, phosphate, citrate, oxalate, and uric acid by healthy schoolchildren using a 12-h collection protocol

Sáez-Torres, Concepción; Rodrigo, D.; Gráses, F.; García-Raja, A.; Gómez, Cristina; Lumbreras, Javier; Frontera, Guiem

doi:10.1007/s00467-014-2755-1

Cited by 21 publications

(13 citation statements)

References 34 publications

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“…It was shown that the urinary excretion of solutes caused an increased risk of lithiasis in children with a family history of urolithiasis. Therefore, it is advised that children with a family history of urolithiasis should be excluded from population studies aimed at setting reference values, such as this study 18 ; (6) there were no data on 24-h urine oxalate excretions, thus this may limit the ability to make meaningful correlations with diet; (7) we could not collect urine samples from patients with primary HO to confirm thresholds where disorders of oxalate metabolism, such as primary HO, might be more likely, and to determine the appropriate cut offs. Despite all these limitations, we think that a good data set of a reference range for morning urine oxalate creatinine ratios was provided with this study.…”

Section: Discussionmentioning

confidence: 99%

Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren

et al. 2016

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Aim: we aimed to establish reference values for urinary oxalate to creatinine ratios in healthy children aged 6–15 years and to investigate the relationship between their nutritional habits and oxalate excretion.Materials and methods: Random urine specimens from 953 healthy children aged 6–15 years were obtained and analyzed for oxalate and creatinine. Additionally, a 24-h dietary recall form was prepared and given to them. The ingredient composition of the diet was calculated. The children were divided into three groups according to age: Group I (69 years, n = 353), Group II (10–12 years, n = 335), and Group III (13–15 years, n = 265).Results: The 95th percentile of the oxalate to creatinine ratio for subjects aged 6–9, 10–12, and 13–15 years were 0.048, 0.042, and 0.042 mg/mg, respectively. The oxalate to creatinine ratio was significantly higher in Group 1 than in Group 2 and Group 3. Urinary oxalate excretion was positively correlated with increased protein intake and negatively correlated with age. A significant positive correlation was determined between urinary oxalate excretion and the proline, serine, protein, and glycine content of diet. Dietary proline intake showed a positive correlation with the urine oxalate to creatinine ratio and was found to be an independent predictor for urinary oxalate.Conclusions: These data lend support to the idea that every country should have its own normal reference values to determine the underlying metabolic risk factor for kidney stone disease since regional variation in the dietary intake of proteins and other nutrients can affect normal urinary excretion of oxalate.

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Section: Discussionmentioning

confidence: 99%

Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren

et al. 2016

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“…It is true that a simplified method would be very much appreciated, especially by the patients themselves (and the parents). However, my conclusion is that the presented procedures by Sáez-Torres et al [3] still have too many pitfalls to be recommendable. The authors neither compared both the afternoon spot urine samples and also the overnight collection with 24-h urinary excretions, nor did the timed urine collection always correlate to the spot urine sample.…”

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confidence: 89%

“…Obviously a lot of questions need to be answered which form the background of the paper by Sáez-Torres and colleagues in a recent issue of Pediatric Nephrology [3].…”

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confidence: 99%

Urinary excretion of calcium, magnesium, phosphate, citrate, oxalate, and uric acid by healthy schoolchildren using a 12-h collection protocol

Höppe

2014

Pediatr Nephrol

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Although we do not have reliable data for the true prevalence of urolithiasis during childhood, the number of patients seen in outpatient clinics and admitted for stonerelated problems is steadily increasing worldwide. As for most pediatric patients a metabolic disease is the reason for stone development, because a high number of patients have severely recurrent urolithiasis, early and proper diagnostic evaluation is necessary to begin adequate and preventive treatment. However, diagnostic evaluation, especially in infants and younger children, is not always easy, and frequently a diagnosis is made late. Diagnostic evaluation should start with repeated urine analysis; but how and which urine should be collected and analyzed? What is the best and most accurate method for urine collection? In a paper published in a recent issue of Pediatric Nephrology, Torres and colleagues describe a more simplified method of urine collection. They propose analysis of late-afternoon spot-urine samples as well as an overnight collection of urine as the most appropriate to evaluate patientspecific urinary risk factors. Is this truly the case?

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“…Próba podniesienia fosfatemii u opisywanej pacjentki (duża doustna podaż fosforanów) wiązała się ze wzrostem nerkowej utraty do wartości 2252 mg/dobę, tj. 102 mg PO 4 /kg cc/dobę (dla przypomnienia wydalanie dobowe u dzieci zdrowych w wieku poniemowlęcym rzadko przekracza 40 mg/kg cc./dobę: niemowlęta starsze 37±11,7 mg/kg cc/db [22], dzieci 5-6 lat 13,8-36,8 mg/kg cc/ db, 6-7 lat 13,2-35,6 mg/kg cc/db, 9-10 lat 8,8-31,8 mg/kg cc/db, 11-12 lat 11,6-32 mg/kg cc/db [23], u dorosłych 0,4-1,3 g/24 godz. [24]).…”

Section: Dyskusjaunclassified

Delayed diagnosis and difficulties in the management of hypophosphatemicrickets in a 7-year-old girl – a case report

Wrzołek¹,

Mertowski²,

Kołłątaj³

et al. 2016

Pediatr. Endocrinol.

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Urinary excretion of calcium, magnesium, phosphate, citrate, oxalate, and uric acid by healthy schoolchildren using a 12-h collection protocol

Abstract: We report data from urine samples collected by using a simplified collection protocol. The observed differences between children with and without a family history of lithiasis could justify that in population studies aimed at setting reference values, the former are excluded.

Cited by 21 publications

References 34 publications

Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren

Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren

Urinary excretion of calcium, magnesium, phosphate, citrate, oxalate, and uric acid by healthy schoolchildren using a 12-h collection protocol

Delayed diagnosis and difficulties in the management of hypophosphatemicrickets in a 7-year-old girl – a case report

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