Urinary excretion of histamine and some of its metabolites in man: Influence of the diet

Keyzer, Jj; Breukelman, H.; Wolthers, B.G.; Vandenheuvel, M; Kromme, N; Berg, W. B. Van Der

doi:10.1007/bf01972348

Cited by 34 publications

(20 citation statements)

References 20 publications

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“…Laboratory tests consisted of complete hemograms, chemistry panel, serum tryptase using the B12 assay with Pharmacia UniCAP tryptase reagents and the Pharmacia Unicap100 analysis device (Pharmacia and Upjohn, Uppsala, Sweden), 15 and the urinary excretion of the histamine metabolites N-methylhistamine and N-methylimidazoleacetic acid, [16][17][18] preferably collected in the fasting state in the morning after voiding of the first portion. For serum tryptase, reference values for healthy individuals are those reported by Pharmacia and Upjohn, showing a geometric mean level of 5.6 g/L and an upper 95th percentile of 13.5 g/L (129 apparently healthy children and adults).…”

Section: Laboratory Testsmentioning

confidence: 99%

Cladribine therapy for systemic mastocytosis

Kluin-Nelemans¹,

Oldhoff²,

Doormaal³

et al. 2003

Blood

220

148

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Patients with systemic mastocytosis (SM) can suffer from disabling symptoms related to mast cell mediator release or mast cell infiltration, requiring mast cell eradication. In the present absence of any curative therapy, a recent case report describing the efficacy of cladribine showed promising results. In a pilot study, the efficacy of cladribine (0.10-0.13 mg/kg in a 2-hour infusion, days 1-5; repeated at 4-8 weeks until 6 cycles) was studied. Ten patients with SM with severe symptoms were treated. Four patients were classified as having indolent or smoldering mastocytosis, 3 as having aggressive systemic mastocytosis, and 3 as having SM with an accompanying hematologic malignancy. Nine patients received 6 courses, 1 patient stopped because of toxicodermia. All responded concerning signs, symptoms, and mast cell parameters (serum tryptase and urinary histamine metabolite excretion), although none achieved a complete remission. Prolonged follow-up is required, as response is ongoing in most cases. One patient relapsed within 11 months and showed a second response. Side effects were mainly related to bone marrow suppression. Single-agent cladribine is an effective and relatively safe treatment for severe systemic mastocytosis. The optimal dose and schedule need to be explored.

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Section: Laboratory Testsmentioning

confidence: 99%

Cladribine therapy for systemic mastocytosis

Kluin-Nelemans¹,

Oldhoff²,

Doormaal³

et al. 2003

Blood

220

148

View full text Add to dashboard Cite

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“…In a previous study [17] it was demonstrated that healthy females may excrete unexpectedly high amounts of free histamine in urine. This phenomenon, probably originating from bacterial histamine production in the vagina or the urologic system, was also observed in this study.…”

Section: Discussionmentioning

confidence: 97%

Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites

et al. 1984

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Urinary excretions of histamine, N tau-methylhistamine and N tau-methylimidazoleacetic acid have been determined for 8 healthy volunteers during 14 consecutive days. Selective decontamination of the digestive tract was performed from day 3 to day 6, followed by total decontamination from day 7 to day 10. Urinary excretions of N tau-methylhistamine and N tau-methylimidazoleacetic acid decreased to a small though significant degree (about 15-20%) after total decontamination, suggesting a histamine production by anaerobic bacteria. Cadaverine decreased for about 70% under both selective and total decontamination, suggesting that this amine in human urine mainly originates from aerobic bacteria in the intestinal tract.

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“…oxidation). The model should be transferable to man because the predominant urinary metabolite after oral histamine challenge of humans (N-tele-methylimidazoleacetic acid [23]) emerges from sequential catabolism by HMT and DAO [6,14]. Finally, the role of paracellular junctions for histamine permeation was defined.…”

Section: Discussionmentioning

confidence: 99%

Paracellular tightness and catabolism restrict histamine permeation in the proximal colon of pigs

Aschenbach

Ahrens

Garz

et al. 2002

Pfl�gers Archiv European Journal of Physiology

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Luminal histamine concentrations can be very high in the intestine without eliciting clinical histaminosis. The intestinal mechanisms that possibly prevent systemic intoxication by luminal histamine were investigated in the present study. Porcine colonic epithelia were mounted in Ussing chambers. After unilateral application of partially (3)H-labelled histamine, mucosal-to-serosal (MS) and serosal-to-mucosal (SM) flux rates were calculated from the contralateral appearance of histamine and the radioactive histamine label (hist-rad; representing histamine plus catabolites). A discrepancy between histamine and hist-rad fluxes was observed in both flux directions, indicating efficient histamine catabolism at all histamine concentrations tested (5, 50 and 100 microM). Catabolism exceeded 65% at 100 microM histamine and reached approximately 100% at 5 microM histamine. Blockade of histamine N-methyltransferase by amodiaquin (100 microM) abolished catabolism completely, whereas blockade of diamine oxidase by aminoguanidine (100 microM) was less effective. MS fluxes of histamine and hist-rad correlated with mannitol fluxes. Mast cell stimulation with the calcium ionophore A23187 (1 microM) induced a twofold larger histamine appearance on the serosal side than the mucosal application of 100 microM histamine. It is concluded that histamine permeation across the porcine proximal colon is restricted by low permeability and sequential catabolism by histamine N-methyltransferase and diamine oxidase.

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Urinary excretion of histamine and some of its metabolites in man: Influence of the diet

Cited by 34 publications

References 20 publications

Cladribine therapy for systemic mastocytosis

Cladribine therapy for systemic mastocytosis

Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites

Paracellular tightness and catabolism restrict histamine permeation in the proximal colon of pigs

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