Urinary excretion of<i>Citrus</i>flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study

Aschoff, Julian; Riedl, Ken M.; Cooperstone, Jessica L.; Högel, Josef; Bosy‐Westphal, Anja; Schwartz, Steven J.; Carle, Reinhold; Schweiggert, Ralf M.

doi:10.1002/mnfr.201600315

Cited by 67 publications

(92 citation statements)

References 36 publications

(92 reference statements)

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“…The few human feeding studies involving flavones available so far reported a low bioavailability for this phytochemical [18,46], which could be ascribable to the low absorption of flavones, as demonstrated in the present investigation. Conversely, several scientific data are available for naringenin and hesperetin absorption, and all studies agree about the importance of colonic microbiota activity on this class of (poly)phenols [47,48,49]. The absorption curves observed in the present work confirm that flavanone metabolism principally occurs in the large intestine.…”

Section: Discussionsupporting

confidence: 80%

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

et al. 2017

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The market of plant-based nutraceuticals and food supplements is continuously growing due to the increased consumer demand. The introduction of new products with relevant nutritional characteristics represents a new way of providing bioactive compounds and (poly)phenols to consumers, becoming a strategy to ideally guarantee the health benefits attributed to plant foodstuffs and allowing the increase of daily bioactive compound intake. A paramount step in the study of nutraceuticals is the evaluation of the bioavailability and metabolism of their putatively active components. Therefore, the aim of the present study was to investigate the absorption profile of the (poly)phenolic compounds contained in three different plant-based food supplements, made of 36 different plant matrices, which were consumed by 20 subjects in an open one-arm study design. Blood samples were collected at baseline and 1, 2, 5, and 10 h after capsule intake. Twenty quantifiable metabolites deriving from different (poly)phenolic compounds were identified. Results showed that the consumption of the three capsules allowed the effective absorption of several (poly)phenolic compounds and metabolites appearing at different times in plasma, thereby indicating different absorption profiles. The capsules thus ensured potential health-promoting molecules to be potentially available to target tissues and organs.

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Section: Discussionsupporting

confidence: 80%

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

et al. 2017

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“…Pharmacokinetics of narirutin after ingestion of orange juice in healthy humans were reported by Silveria et al [27] . The majority of oral intake-narirutin is considered to reach the colon, and colonic microbiota deglycosylate narirutin to naringenin, that is then absorbed by colonocytes [28] . Thus, it is considered that narirutin exists like a prodrug, and its aglycone naringenin works as an active form within the body.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of flavonoids in Citrus jabara fruit peels

Azuma

Murakami²,

Azuma³

et al. 2018

Trends Immunother

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Currently, about half of people in Japan suffer from allergic diseases. Thus, Citrus jabara fruits have been paid attention as one of quite effective anti-allergic functional foods. C. jabara is an endemic species originally grown only in Kitayama village, Wakayama prefecture in Japan. Although genetic characterization and diversity of various Citrus fruits including C. jabara were researched, but there is room for the study on flavonoids characteristics in C. jabara fruit. For the alleviation of allergic symptom, anti-inflammatory effects are also important. In this study, characteristics of flavonoids in C. jabara fruit peels, and the anti-inflammatory effects of these purified flavonoids were investigated. Our results revealed that C. jabara is a unique Citrus that almost all of flavonoids in fruit peels was narirutin. There was no Citrus species with a flavanone glycosides content ratio like C. jabara. Although anti-inflammatory effects of narirutin was weak, but its aglycone naringenin exhibited following inhibitory effects: nitric oxide synthesis (IC 50 = 105 μM), nitric oxide synthase induction, Interleukin-6 synthesis (IC 50 = 65 μM), and inducible soluble epoxide hydrolase activity (IC 50 = 267 μM). Since narirutin is deglycosylated to naringenin that is then absorbed by colonocytes, it is considered that narirutin exists like a prodrug and its aglycone naringenin works as an active form of anti-inflammatory effect in a living body at oral ingestion of C. jabara fruit peels. Keywords: Citrus jabara; anti-inflammatory effects; flavonoids; narirutin; naringenin ARTICLE INFO

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“…However, short activity cessation slightly enhanced metabolites excretion [82]. In the same line, it was also shown that the urinary metabolites excretion does not differ after fresh oranges or pasteurized orange juice consumption, even if the latter contains about half of total flavanones amount [83].…”

Section: Bioavailability Of Naringeninmentioning

confidence: 99%

The Therapeutic Potential of Naringenin: A Review of Clinical Trials

et al. 2019

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Naringenin is a flavonoid belonging to flavanones subclass. It is widely distributed in several Citrus fruits, bergamot, tomatoes and other fruits, being also found in its glycosides form (mainly naringin). Several biological activities have been ascribed to this phytochemical, among them antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic and cardioprotective effects. Nonetheless, most of the data reported have been obtained from in vitro or in vivo studies. Although some clinical studies have also been performed, the main focus is on naringenin bioavailability and cardioprotective action. In addition, these studies were done in compromised patients (i.e., hypercholesterolemic and overweight), with a dosage ranging between 600 and 800 μM/day, whereas the effect on healthy volunteers is still debatable. In fact, naringenin ability to improve endothelial function has been well-established. Indeed, the currently available data are very promising, but further research on pharmacokinetic and pharmacodynamic aspects is encouraged to improve both available production and delivery methods and to achieve feasible naringenin-based clinical formulations.

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Urinary excretion ofCitrusflavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study

Abstract: Despite 2.4-fold higher doses, excretion of flavanones from ingested fresh orange fruit did not differ from that following orange juice consumption, possibly due to a saturation of absorption or their entrapment in the fiber-rich matrix of the fruit.

Cited by 67 publications

References 36 publications

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

Anti-inflammatory effects of flavonoids in Citrus jabara fruit peels

The Therapeutic Potential of Naringenin: A Review of Clinical Trials

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