URINARY EXCRETION OF NORADRENALINE AND ITS METABOLITES AT TEN-MINUTE INTERVALS AFTER INTRAVENOUS INJECTION OF dl-NORADRENALINE-2-C14*

Abstract

It is well-established that noradrenaline is the neurohormone of the sympathetic (adrenergic) nerves (1-3) and is so released at the nerve endings. Further, it is known that after release, noradrenaline is rapidly inactivated and concomitantly, a number of metabolites are formed (4-7) ( Figure 1) that biologically are relatively inactive. The rapidity, however, with which these metabolic products are formed in man and excreted in the urine is not precisely known.In the earlier work on the metabolism of noradrenaline, urine collections were made at long intervals after infusion, i.e., at 1-hour intervals, for 24 hours (5, 7, 8), and so gave limited information about events immediately after the infusion of noradrenaline. Therefore, these experiments were designed to give additional information about noradrenaline metabolites and their rates of formation and excretion as seen in the early periods after inactivation. METHODSSix women between 20 and 35 years old were injected intravenously with 9.5 ,uc (80 ,g) of dl-noradrenaline-

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