Urinary Excretion of Pancreatic Stone Protein in Diabetic Nephropathy.

Abstract

Urinary pancreatic stone protein (PSP) levels were measured in 68 diabetic patients and 170 healthy controls to investigate the relationship between the progression of diabetic nephropathy and PSP excretion. Urinary albumin, N-acetyl-p-glucosaminidase (NAG), ax-microglobulin, creatinine clearance, and the blood PSP level were also determined in the diabetic patients. The urinary glucose level and glycemic control did not influence the urinary PSP level. In patients with normoalbuminuria (urinary albumin <20 mg/gCr, n=31), microalbuminuria (20-200 mg/Cr, n=19), and macroalbuminuria (>200 mg/gCr, n=18), the mean urinary PSP level was 347, 507, and 860 |0g/gCr, respectively. These levels were significantly higher than the level in normal volunteers (168 |ilg/gCr, p<0.01). A significant positive correlation was observed between the urinary PSP level and the NAGor aj-microglobulin levels (p<0.01). There was a stronger correlation with ocjmicroglobulin. Blood PSP levels were also elevated in patients who had renal impairment with a decreased creatinine clearance. In conclusion, urinary PSP excretion was increased from the initial stage of diabetic nephropathy and this increase became more marked as nephropathy progressed. Increased PSP excretion may reflect renal tubular dysfunction. (Internal Medicine 37: 500-503, 1998) Key words: urinary pancreatic stone protein (PSP), urinary albumin, urinary armicroglobulin, urinary N-acetyl-p-glucosaminidase (NAG)

Association of Serum PSP/REG Iαwith Renal Function in Type 2 Diabetes Mellitus

“…Another interesting observation in this study was that PSP/REG Iα associated with eGFR and SCr. Previous studies reported that urinary PSP/REG Iα excretion is increased in patients with renal disease and diabetic nephropathy [14,21]. This study revealed that serum PSP/REG Iα levels were associated with eGFR in patients with and without T2DM.…”

“…It has been found in the urine and renal calculi of healthy individuals [13], which suggested a physiological role of PSP/REG Iα in the kidney. Sobajima et al reported that urinary PSP/REG Iα was increased significantly in patients with various renal diseases, including diabetic nephropathy [14,15]. Moreover, a previous study by the present researchers has found increased serum levels of PSP/REG Iα in patients with diabetic nephropathy [16].…”

Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease

“…1 ). Furthermore, it has been also identified in human kidney and urine which is increased in diabetic patients [21] , [22] , suggesting that Reg1 may be involved in diabetic kidney hypertrophy as a kidney growth factor. As EGF in the fluid of collecting duct cysts has been shown to stimulate the cyst growth, a similar role of Reg1 in proximal tubule cysts will be anticipated [1] .…”

Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases

“…Sobajima et al reported that urinary PSP excretion was increased from the initial stage of diabetic nephropathy and the increase became more marked as nephropathy progressed. They suggested that increased PSP excretion might reflect renal tubular dysfunction (79). Total serum PSP level tends to increase in severe acute pancreatitis than in mild acute pancreatitis (76,80).…”