Urinary excretion of pyridinoline and deoxypyridinoline measured by immunoassay in hypothyroidism

Nakamura, Hirotoshi; Mori, Tomoko; Genma, Rieko; Suzuki, Yoshikazu; Natsume, Hiroko; Andoh, Shinichiro; Kitahara, Ryo; Nagasawa, Shinsuke; Nishiyama, Kozo; Takai, Yoshimi

doi:10.1046/j.1365-2265.1996.691513.x

Cited by 14 publications

(2 citation statements)

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“…This was accompanied by a decrease in serum osteocalcin and urinary bone markers, which were lower than those values of controls when patients were hypothyroid, as expected (17,18). We have also shown that, irrespective of thyroid function, menopausal status increased serum osteoprotegerin levels.…”

Section: Discussionmentioning

confidence: 62%

“…It has been proposed that the increased cardiovascular risk associated with hypothyroidism or a reduced renal clearance of osteoprotegerin could be possible explanations (10). Furthermore, we cannot completely exclude the possibility that the elevation in serum osteoprotegerin concentrations during hypothyroidism might represent a response to the inhibition of bone metabolism that results from thyroid hormone deficiency (17,20), although this mechanism seems unlikely as osteoprotegerin usually increases in response to increased bone resorption (4), and is positively associated with osteocalcin levels (5).…”

Section: Discussionmentioning

confidence: 79%

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Thyroid hormone deficiency and postmenopausal status independently increase serum osteoprotegerin concentrations in women

Botella-Carretero

Álvarez‐Blasco²,

Millán³

et al. 2007

eur j endocrinol

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Objective: To study the impact of thyroxine (T4) withdrawal on serum osteoprotegerin concentrations in women, using a healthy euthyroid control group matched for age and postmenopausal status as reference. Subjects and design: Nineteen women with differentiated thyroid carcinoma were studied the last day on T4 suppressive treatment, 4-7 days after withdrawal and the day before whole body scanning. Eighteen women matched for age and postmenopausal status served as controls. Serum thyroid hormones, urinary bone markers and serum osteoprotegerin concentrations were measured. Statistical methods included repeated measures analysis of variance and one-way analysis of variance. Results: Patients progressed from subclinical or mild hyperthyroidism at baseline to normal free T4 and triiodothyronine levels 4-7 days later, ending in overt hypothyroidism before scanning. Serum osteoprotegerin increased, and urinary deoxypyridolines/creatinine and pyridolines/creatinine ratios decreased, with acute hypothyroidism (PZ0.026, PZ0.003, and P!0.001 respectively). Urinary deoxypyridolines/creatinine ratio, pyridolines/creatinine ratio, and serum osteocalcin during hypothyroidism were lower compared with those of healthy controls (PZ0.023, PZ0.019, and PZ0.011 respectively). Serum osteoprotegerin concentrations were higher in postmenopausal patients when compared with premenopausal ones, irrespective of the changes in thyroid function (PZ0.001). Conclusion: Serum osteoprotegerin concentrations increase following acute hypothyroidism after T4 withdrawal in women with differentiated thyroid carcinoma, and also with postmenopausal status.European Journal of Endocrinology 156 539-545

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Section: Discussionmentioning

confidence: 62%