Urinary Excretion of Tamm-Horsfall Protein in Women with Recurrent Urinary Tract Infections

Reinhart, Harald H.; Obedeanu, N.; Hooton, Thomas M.; Stamm, Walter E.; Sobel, Jack D.

doi:10.1016/s0022-5347(17)39687-8

Cited by 25 publications

(13 citation statements)

References 14 publications

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“…Ent (EMC Microcollections gmbh) capture by LCN2 was tested at a 1:1:1 Ent:Fe:LCN2 ratio. The complex was washed 5 times on a 10-k micron, and binding was detected by its red coloration or by retention of 55 Fe.…”

Section: Methodsmentioning

confidence: 99%

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α–Intercalated cells defend the urinary system from bacterial infection

Paragas¹,

Kulkarni²,

Werth³

et al. 2014

J. Clin. Invest.

129

111

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α-Intercalated cells (A-ICs) within the collecting duct of the kidney are critical for acid-base homeostasis. Here, we have shown that A-ICs also serve as both sentinels and effectors in the defense against urinary infections. In a murine urinary tract infection model, A-ICs bound uropathogenic E. coli and responded by acidifying the urine and secreting the bacteriostatic protein lipocalin 2 (LCN2; also known as NGAL). A-IC-dependent LCN2 secretion required TLR4, as mice expressing an LPS-insensitive form of TLR4 expressed reduced levels of LCN2. The presence of LCN2 in urine was both necessary and sufficient to control the urinary tract infection through iron sequestration, even in the harsh condition of urine acidification. In mice lacking A-ICs, both urinary LCN2 and urinary acidification were reduced, and consequently bacterial clearance was limited. Together these results indicate that A-ICs, which are known to regulate acid-base metabolism, are also critical for urinary defense against pathogenic bacteria. They respond to both cystitis and pyelonephritis by delivering bacteriostatic chemical agents to the lower urinary system.

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Section: Methodsmentioning

confidence: 99%

“…In addition, the urogenital system constitutively expresses antimicrobial proteins (AMPs) that are released into the urine, most strikingly by loop of Henle (54,55). The AMPs typically disrupt the phospholipid membranes of different types of microorganisms, including both bacteria and fungi, rather than target a specific species (56,57).…”

Section: Introductionmentioning

confidence: 99%

α–Intercalated cells defend the urinary system from bacterial infection

Paragas¹,

Kulkarni²,

Werth³

et al. 2014

J. Clin. Invest.

129

111

View full text Add to dashboard Cite

show abstract

“…Amongst them, secretory IgA has been shown to be decreased in girls with recurrent UTIs and normal urinary tracts [66] as compared with girls without a history of UTIs. In contrast, the most abundant urinary protein (TammHorsfall protein) does not seem to be changed in recurrent UTI [168,169].…”

Section: Mucosal Immunitymentioning

confidence: 82%

Urinary Tract Infection. Why Do Some Children Get Complications, While Others Dont?

Chromek¹,

Brauner²

2007

CPR

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Urinary tract infection, one of the commonest bacterial diseases in children, carries a substantial risk of serious complications. Amongst them, renal scarring and recurrent infections seem to be the most important. In this review, we analyze the pathogenesis of urinary tract infection in order to identify those children who run the highest risk of unfavorable outcome. During infection, multiple bacterial and host factors interact with each other. Bacteria possess specific characteristics involved in the process of adhesion, invasion, survival and host damage during infection. Host factors also substantially participate in the pathogenesis of the disease. According to current knowledge, the specific host response appears to be the main factor predisposing for complications. However, prompt and adequate treatment of acute urinary tract infection remains the most important measure to prevent scarring. Dysfunctional holding and elimination of urine, on the other hand, mainly seem to influence the development of recurrent infection. Despite intensive research for many years, urinary tract infections are still a challenge for patients and health care professionals.

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“…THP-spezifische Antikörperre-aktionen sind bei Patienten mit HWI, insbesondere bei Pyelonephritis zu beobachten. [26]. Bei Diabetikern ist dieser Schutzmechanismus ebenfalls beeinträchtigt, da die Konzentration des Uromukoids im Harn deutlich reduziert ist [30].…”

Section: Host Factors · Urine Composition · Virulence Factors · Bacteunclassified

Rezidivierende Harnweginfektionen der Frau

Oelschlaeger

Fünfstück

2006

Urologe

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The interactions of host-specific and microbial factors are responsible for recurrent urinary tract infections (rUTI). The anatomical properties of the female urogenital tract favor colonization by uropathogens. Local factors such as glucose concentration of the urine, stability of the lactobacilli population, the influence of estrogens, the activity of Tamm-Horsfall protein or of defensins, and disturbance of the systemic defense mechanisms dictate the course of an infection. The most prominent uropathogen is E. coli. It expresses various virulence factors including adhesions, toxins, iron uptake systems, and a capsule. It is still unclear if there are virulence factors characteristic for E. coli strains causing rUTI. The formation of intracellular reservoirs by invasion of uroepithelial cells by E. coli could be another, as yet little noticed cause for rUTI. Therefore, in cases of rUTI the application of intracellularly active antibiotics should be considered.

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Urinary Excretion of Tamm-Horsfall Protein in Women with Recurrent Urinary Tract Infections

Cited by 25 publications

References 14 publications

α–Intercalated cells defend the urinary system from bacterial infection

α–Intercalated cells defend the urinary system from bacterial infection

Urinary Tract Infection. Why Do Some Children Get Complications, While Others Dont?

Rezidivierende Harnweginfektionen der Frau

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