Urinary glyphosate kinetics after occupational exposure

Kohsuwan, Kanyapak; Intayoung, Unchisa; Khacha-ananda, Supakit; Sapbamrer, Ratana; Koonrungsesomboon, Nut; Techatoei, Sujitra; Wunnapuk, Klintean

doi:10.1016/j.ijheh.2022.114021

Cited by 13 publications

(2 citation statements)

References 25 publications

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“…Furthermore, toxicokinetics of glyphosate were investigated in 59 Thai farmers before spraying, and up to 72 h post-application. Among one-time sprayers, the average urinary glyphosate concentration measured 27.4 ng•mL −1 , markedly higher than values reported in other countries (156). Subsequently, the impact of glyphosate application on oxidative stress, inflammation, and lung function was scrutinized in other 180 Thai farmers.…”

Section: Farmers and Agricultural Communitiesmentioning

confidence: 88%

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

Birolli,

Lanças,

dos Santos Neto

et al. 2024

Front. Public Health

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IntroductionPollution has emerged as a significant threat to humanity, necessitating a thorough evaluation of its impacts. As a result, various methods for human biomonitoring have been proposed as vital tools for assessing, managing, and mitigating exposure risks. Among these methods, urine stands out as the most commonly analyzed biological sample and the primary matrix for biomonitoring studies.ObjectivesThis review concentrates on exploring the literature concerning residual pesticide determination in urine, utilizing liquid and gas chromatography coupled with mass spectrometry, and its practical applications.MethodThe examination focused on methods developed since 2010. Additionally, applications reported between 2015 and 2022 were thoroughly reviewed, utilizing Web of Science as a primary resource.SynthesisRecent advancements in chromatography-mass spectrometry technology have significantly enhanced the development of multi-residue methods. These determinations are now capable of simultaneously detecting numerous pesticide residues from various chemical and use classes. Furthermore, these methods encompass analytes from a variety of environmental contaminants, offering a comprehensive approach to biomonitoring. These methodologies have been employed across diverse perspectives, including toxicological studies, assessing pesticide exposure in the general population, occupational exposure among farmers, pest control workers, horticulturists, and florists, as well as investigating consequences during pregnancy and childhood, neurodevelopmental impacts, and reproductive disorders.Future directionsSuch strategies were essential in examining the health risks associated with exposure to complex mixtures, including pesticides and other relevant compounds, thereby painting a broader and more accurate picture of human exposure. Moreover, the implementation of integrated strategies, involving international research initiatives and biomonitoring programs, is crucial to optimize resource utilization, enhancing efficiency in health risk assessment.

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Section: Farmers and Agricultural Communitiesmentioning

confidence: 88%

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

Birolli,

Lanças,

dos Santos Neto

et al. 2024

Front. Public Health

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show abstract

“…Additionally, NHANES relies on a single spot urine sample for glyphosate measurement, introducing the possibility of non-differential measurement error. Furthermore, NHANES did not measure levels of AMPA, and, although urine is the most frequently employed biomarker to measure population exposure to glyphosate (Faniband et al, 2021;Ferreira et al, 2021;Lemke et al, 2021;Connolly and Koch, 2023), its short half-life, typically between 9 and 18 h (Connolly et al, 2019;Zoller et al, 2020;Kohsuwan et al, 2022), and uncertainty about its bioaccumulation in the human body, may limit its use as a biomarker of chronic exposure. Concerning the outcome, physical performance was based on self-reports, and the prevalence of certain impairments was low, constraining our ability to detect associations.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Glyphosate exposure, muscular health and functional limitations in middle-aged and older adults.

Jauregui Zunzunegui,

Rodríguez Artalejo,

Tellez Plaza

et al. 2024

ISEE Conference Abstracts

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Background: Glyphosate is the most widely used herbicide worldwide, both in domestic and industrial settings. Experimental research in animal models has demonstrated changes in muscle physiology and reduced contractile strength associated with glyphosate exposure, while epidemiological studies have shown associations between glyphosate exposure and adverse health outcomes in critical biological systems affecting muscle function.Methods: This study used data from a nationally representative survey of the non-institutionalized U.S. general population (NHANES, n = 2132). Urine glyphosate concentrations were determined by ion chromatography with tandem mass spectrometry. Hand grip strength (HGS) was measured using a Takei Dynamometer, and relative strength estimated as the ratio between HGS in the dominant hand and the appendicular lean mass (ALM) to body mass index (ALMBMI) ratio. Low HGS and low relative HGS were defined as 1 sex-, age-and race-specific SD below the mean. Physical function limitations were identified as significant difficulty or incapacity in various activities.Results: In fully-adjusted models, the Mean Differences (MD) and 95% confidence intervals [95%CI] per doubling increase in glyphosate concentrations were − 0.55 [-1.09, − 0.01] kg for HGS in the dominant hand, and − 0.90 [-1.58. − 0.21] kg for HGS/ALMBMI. The Odds Ratios (OR) [95% CI] for low HGS, low relative HGS and functional limitations by glyphosate concentrations were 1.27 [1.03, 1.57] for low HGS; 1.43 [1.05; 1.94] for low relative HGS; 1. 33 [1.08, 1.63] for stooping, crouching or kneeling difficulty; 1.17 [0.91, 1.50] for lifting or carrying items weighting up to 10 pounds difficulty; 1. 21 [1.01, 1.40] for standing up from armless chair difficulty; and 1.47 [1.05, 2.29] for ascending ten steps without pause difficulty. Conclusions: Glyphosate exposure may be a risk factor for decreased grip strength and increased physical functional limitations. More studies investigating the influence of this and other environmental pollutants on functional aging are needed.

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Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment

Reale,

Zare Jeddi,

Paini

et al. 2024

Environment International

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Urinary glyphosate kinetics after occupational exposure

Cited by 13 publications

References 25 publications

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

Glyphosate exposure, muscular health and functional limitations in middle-aged and older adults.

Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment

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