Urinary Hormone Metabolite Levels in Patients With Cancer of the Breast, Prostate and Lung*

Marmorston, Jessie

doi:10.1111/j.1749-6632.1966.tb45448.x

Cited by 23 publications

References 15 publications

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Testicular morphology and germ cell DNA synthesis in the testis of patients with prostatic carcinoma

Markewitz

Veenema

Fingerhut

et al. 1971

Cancer

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Testes of 175 patients with histologically proved carcinoma of the prostate were biopsied and processed for conventional as well as radioautographic study. Satisfactory spermatogenesis was preserved in 40‐45% of the biopsied testis. In 35‐40%, spermatogenesis was active, but there was clear evidence of depletion in the maturation process. The remaining 20‐25% showed atrophy and hyalinization. Radioautographic study revealed that the number of DNA‐syn‐thesizing spermatogonia per cross‐sectioned tubule was reduced from what was previously observed in the healthy adult male. No correlation could be found between testicular morphology, DNA synthesis of the germ cells, serum testosterone levels, and total urinary gonadotropins. It appears that the pituitary‐gonadal axis in the prostatic carcinoma patient is altered. This alteration, however, is not clearly delineated by the laboratory methods presently available.

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Testicular morphology and germ cell DNA synthesis in the testis of patients with prostatic carcinoma

Markewitz

Veenema

Fingerhut

et al. 1971

Cancer

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Steroid hormones and human breast cancer.An hypothesis

Adams¹

1977

Cancer

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The likely occurrence of two distinct types of human breast cancer is discussed. In the development of the "Western-environmental" or "adrenal" type, it is proposed that dehydroepiandrosterone sulphate (DHEAS) , secreted by the adrenal, may be implicated. This steroid is metabolized by mammary tumors to active androgens and estrogens. That these metabolic pathways are very similar to that in skin is emphasized and this is possibly explained by evolution of the mammary gland from primitive sweat glands. Formation of DHEAS from DHEA in mammary tumors, claimed to be correlated with an individual subject's prognosis and response to hormone ablation, is discussed in the light of a possible regulatory role of the sulphotransferase. It is proposed furthermore that a specific control of DHEAS secretion in the adrenal may exist at the level of the sulphurylation step. Nutritional factors are also possibly implicated here and these are discussed in the light of: 1) a possible higher secretion rate of DHEAS in obese subjects; and 2) the low breast cancer incidence in the Japanese and the accompanying low blood DHEAS levels.

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Endocrinology

Wang

Bulbrook

1977

Principles of Surgical Oncology

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Urinary Hormone Metabolite Levels in Patients With Cancer of the Breast, Prostate and Lung*

Cited by 23 publications

References 15 publications

Testicular morphology and germ cell DNA synthesis in the testis of patients with prostatic carcinoma

Testicular morphology and germ cell DNA synthesis in the testis of patients with prostatic carcinoma

Steroid hormones and human breast cancer.An hypothesis

Endocrinology

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