Urinary hydroxyproline and serum alkaline phosphatase in sickle cell disease

Mohammed, S; Suleiman, Suleiman A.; Addae, S; Annobil, Samuel H.; Adzaku, Festus; Kadoummi, Osama F.; Richards, John T.

doi:10.1016/0009-8981(91)90301-r

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…Because alkaline phosphatase was statistically associated with log 10 sICAM‐1 independently of the association of direct bilirubin to log 10 sICAM‐1, it seemed likely that the elevation of alkaline phosphatase in patients with higher sICAM‐1 levels was because of pathology in the bone, potentially vaso‐occlusive damage. Supporting this interpretation, other investigators have found that most of the variation in alkaline phosphatase activity in patients with SCD at steady state was contributed by the bone isoform (Mohammed et al , 1991).…”

Section: Resultsmentioning

confidence: 71%

Levels of soluble endothelium‐derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality

Kato¹,

Martyr²,

et al. 2005

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SummaryEndothelial cell adhesion molecules orchestrate the recruitment and binding of inflammatory cells to vascular endothelium. With endothelial dysfunction and vascular injury, the levels of endothelial bound and soluble adhesion molecules increase. Such expression is modulated by nitric oxide (NO), and in patients with sickle cell disease (SCD), these levels are inversely associated with measures of NO bioavailability. To further evaluate the role of endothelial dysfunction in a population study of SCD, we have measured the levels of soluble endothelium-derived adhesion molecules in the plasma specimens of 160 adult patients with SCD during steady state. Consistent with a link between endothelial dysfunction and end-organ disease, we found that higher levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) were associated with markers indicating renal dysfunction and hepatic impairment. Analysis of soluble intercellular cell adhesion molecule-1 (sICAM-1), sE-selectin and sP-selectin levels indicated partially overlapping associations with sVCAM-1, with an additional association with inflammatory stress and triglyceride levels. Importantly, increased soluble adhesion molecule expression correlated with severity of pulmonary hypertension, a clinical manifestation of endothelial dysfunction. Soluble VCAM-1, ICAM-1, and E-selectin were independently associated with the risk of mortality in this cohort. Our data are consistent with steady state levels of soluble adhesion molecules as markers of pulmonary hypertension and risk of death.

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Section: Resultsmentioning

confidence: 71%

Levels of soluble endothelium‐derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality

Kato¹,

Martyr²,

et al. 2005

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“…Delayed growth and bone destruction may contribute to the elevated levels of alkaline phosphatase. Higher levels of alkaline phosphatase may be due to associated vasoocclussive crises involving the bones rather than pathology of the liver [24,25]. The level of the heat-labile alkaline phosphatase indicates severity of bone damage and is a useful guide of progress in the management of bone pains in sickle cell anaemia [4,26].…”

Section: Discussionmentioning

confidence: 99%

Biochemical Indicator of Sickle Cell Disease: Preliminary Report from India

et al. 2011

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Blood biochemistry has significant effect on pathophysiology of human body. Recently few studies found the association of biochemical abnormalities in sickle cell patients. Sickle cell disease showed clinical variability where African ancestors have severe phenotype than Indian sicklers. Our aim was to evaluate the biochemicals in sickle cell patients and their effect on severity. Here we present the comparative biochemical levels in sickle cell patients as well as controls. Sickle cell patients diagnosed by HPLC and biochemical analysis done by Beckman-auto analyzer. T test applied for statistical analysis. Result showed the renal abnormality lesser in patients and related biochemical within the normal range and statistically not significant. Electrolytes, hepatic enzymes, alkaline phosphatase and glucose were elevated and statistically significant (P value \0.05). Observation of the study concludes the biochemical abnormality play a significant role in sickle cell patient's physiopathology and can be used to management of the disease.

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“…Because t-hydroxyproline is predominantly found in collagen, release of t-Hyp is normally due to an injury of this protein by inflammation processes. Therefore, t-Hyp is supposed to be an appropriate marker for the decomposition of bone and connective tissue and thus useful for the early diagnosis of associated bone diseases [17][18][19][20] and tumors [21].…”

Section: Introductionmentioning

confidence: 99%