Urinary infection in the elderly

Artero, Elisa Álvarez; Núñez, Amaia Campo; Bravo, Moisés García; Calvo, Ojeda; Belhassen-García, Moncef; Lledías, Javier Pardo

doi:10.1016/j.rceng.2018.10.014

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…It has many resistance mechanisms, such as antibiotic-modifying enzymes, obtaining plasmids encoding drug-resistance genes, limited penetration of antibiotics, and the possibility of generating energy-dependent pumps 24 . Elderly patients infected by Pseudomonas aeruginosa could even relapse after antibiotic treatment 25 . Understanding the characteristics of these bacteria could help clinicians pay more attention to specific bacteria in preoperative urine culture to better infection prevention and rational use of antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study

Lin,

Yang,

et al. 2023

Sci Rep

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This study aimed to analyze the infection risk factors for transurethral resection of the prostate (TURP) and establish predictive models to help make personalized treatment plans. Our study was designed one-center and retrospectively enrolled 1169 benign prostatic hyperplasia (BPH) patients. Risk factors were explored for postoperative infection. A TURP-postoperative infection (TURP-PI) model with infection prediction values was created. The improved-TURP-PI (I-TURP-PI) model, including extra new factors (pathogens species), was also built to see whether it could optimize the prediction abilities. At last, we developed a nomogram for better clinical application. Operation time, preoperative indwelling urinary catheter (PIUC), and positive preoperative urine culture were independent risk factors (all P < 0.05). Interestingly, pathogens species in pre-surgery urine (PEnterococcus faecium = 0.014, PPseudomonas aeruginosa = 0.086) were also independent risk factors. Patients with positive Enterococcus faecium (37.50%) were most likely to have postoperative infection. We built two models with AUCTURP-PI = 0.709 (95% CI 0.656–0.763) and AUCI-TURP-PI = 0.705 (95% CI 0.650–0.760). The nomogram could help improve the prediction ability. To our knowledge, our study is the first to use pathogen species in urine before surgery as risk factors for infection prediction after TURP. TURP-PI and I-TURP-PI models have essential roles in predicting patients' postoperative infections and in better postoperative antibiotic decision-making.

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Section: Discussionmentioning

confidence: 99%

Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study

Lin,

Yang,

et al. 2023

Sci Rep

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“…15 Urinary tract infections (UTIs) have been identified as a common cause for hospital admission and the second most common cause for delayed hospital discharge for older adults. 27,28 In cases of sepsis for this demographic, UTI is the most common cause of infection at 45%, just ahead of pneumonia at 43%. 27 Confusion, delirium, and incontinence often co-occur with UTIs in older adults and are highly associated with increased risk for falls in this population.…”

Section: Methodsmentioning

confidence: 99%

“…Urinary tract infections (UTIs) have been identified as a common cause for hospital admission and the second most common cause for delayed hospital discharge for older adults 27,28. In cases of sepsis for this demographic, UTI is the most common cause of infection at 45%, just ahead of pneumonia at 43% 27.…”

mentioning

confidence: 99%

Physical Therapy and Discharge Disposition Following Acute Hospitalization for UTI in Community-Dwelling Older Adults

Miller¹,

Moore²,

Stikeleather³

2021

Journal of Acute Care Physical Therapy

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Background: Bed rest during acute hospitalization is associated with new-onset mobility impairments in community-dwelling older adults, resulting in discharge to skilled nursing facilities rather than home. Purpose: The purpose of this retrospective study is to determine whether the number of physical therapy (PT) visits is related to discharge disposition following an acute hospitalization for urinary tract infection (UTI) in the older adult population. Methods: Medical records over a 3-year period of 523 community-dwelling older adults (65 years and older) admitted from home functionally independent were reviewed. Demographic and patient characteristics, including age, gender, living status, length of stay (LOS), discharge disposition, and the number of PT visits, were collected. Multinomial regression was conducted to determine predictors of disposition. Results:The multinomial logistic regression model was statistically significant, χ 2 (2) = 6.90, P = .032. Older age, longer LOS with fewer PT visits during acute hospitalization, and a higher comorbidity score were significant predictors of hospital discharge to subacute rehabilitation facilities than those who were able to return home with home health PT. These variables were not predictors of the disposition for younger patients with fewer comorbidities. Limitations: Due to the retrospective nature of this study, assessment of potential preexisting levels of frailty, standardized delivery of PT, and level of activity outside of PT could not be performed. Conclusions: Reduced frequency of physical therapist intervention for older adults hospitalized with UTI was associated with discharge to rehabilitation in a skilled nursing facility compared with those of similar age with increased PT intervention frequency.Multimorbidity, which is a common occurrence with aging, significantly increases the risk of mobility impairments. 7,8 For the older adult, staying in bed for as little as half a day represents an increased risk of developing a new-onset disability. 9 With nearly 70% of older adults being discharged from hospitals below their prior level of function, researchers forecast exponential growth in disability, compounding the rate of health care spending for the senior population over the next decade. [10][11][12] Immobility during a hospital stay accounts for approximately 50% of previously independent community-dwelling older adults discharging to a skilled nursing facility rather than returning home. This postacute care disposition increases the cost of each episode of care for both patients and payers. 5,[13][14][15] When older adults are discharged from acute care hospitals to skilled nursing facilities, they are less likely to recover preadmission levels of function and are at risk of being permanently institutionalized. 15,16 Even more alarming is the high 1-year mortality rate following the hospitalization of older adults. 17 Baztan et al 17 reported that 32.6% of community-dwelling older adults died within 1 year of hospitalization due to acute illne...

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“…[1] The prevalence increases with age, and the elderly and immunocompromised patients are more likely to develop septic shock. [2] Mortality increases with the degree of multiorgan failure. [3] The pathogen may be any bacterium, fungus, virus, or parasite.…”

Section: Introductionmentioning

confidence: 99%

CD3D and CD247 are the molecular targets of septic shock

et al. 2023

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Septic shock is a serious systemic disease with circulatory failure and abnormal cell metabolism caused by sepsis. However, the relationship between CD3D and CD247 and septic shock remains unclear. The septic shock datasets GSE33118 and GSE142255 profiles were generated from the gene expression omnibus databases GPl570, GPl17586. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis was performed. The construction and analysis of protein–protein interaction (PPI) network, functional enrichment analysis, gene set enrichment analysis (GSEA) were performed. Gene expression heat map was drawn. Immune infiltration analysis was performed. Comparative toxicogenomics database (CTD) analysis were performed to find the disease most related to the core gene. Targets can was used to screen miRNAs regulating the hub DEGs. 467 DEGs were identified. According to the gene ontology analysis, they were mainly enriched in the regulation of immune response, cell activation, signaling receptor activity, enzyme binding. Kyoto encyclopedia of genes and genomes analysis showed that they were mainly enriched in the TCR signaling pathway, Fc epsilon RI signaling pathway. GSEA showed that the DEGs were mainly enriched in immune response regulation, cell activation, TCR signaling pathway, Fc epsilon RI signaling pathway. Positive regulation of Fc receptor signaling pathway, PID IL12 2 pathway, immune response was observed in go enrichment items in the enrichment items of metascape. PPI networks got 5 core genes. Gene expression heat map showed that 5 core genes (CD247, Lck, cd3e, cd3d, ITK) were lowly expressed in the sepsis shock samples and highly expressed in the normal samples. CTD analysis showed that 5 core genes (CD247, Lck, cd3e, cd3d, ITK) were found to be associated with hemorrhage and necrosis. Low expression of cd3d, CD247 was observed in septic shock, and the lower the level of cd3d, CD247, the worse the prognosis.

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Urinary infection in the elderly

Cited by 7 publications

References 20 publications

Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study

Pathogen species are the risk factors for postoperative infection of patients with transurethral resection of the prostate: a retrospective study

Physical Therapy and Discharge Disposition Following Acute Hospitalization for UTI in Community-Dwelling Older Adults

CD3D and CD247 are the molecular targets of septic shock

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