Urinary leukotriene E4 levels in atopic and non-atopic preschool children with recurrent episodic (viral) wheezing: a potential marker?

Marmarinos, Antonios; Saxoni-Papageorgiou, Photini; Cassimos, Dimitrios; Manoussakis, Emmanuel; Tsentidis, Charalampos; Doxara, Alexia; Paraskakis, I.; Gourgiotis, Dimitrios

doi:10.3109/02770903.2014.990092

Cited by 17 publications

(15 citation statements)

References 25 publications

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“…There are higher levels of U-LT inacute wheeze episode in preschool atopic children, compared to non-atopic. [ 90 ] The measurement of U-LT could be a non-invasive method for atopic predisposition and diagnosis and management of asthma in preschool children. [ 91 ] It is known that environmental tobacco smoke exposure is associated with higher U-LT.[ 92 ]…”

Section: Other Biomarkersmentioning

confidence: 99%

Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice

Sánchez‐García

Mena

Quirce

2017

European Clinical Respiratory Journal

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Asthma is a common disease in both high and lower income countries that starts early and persists often for life. A correct and accurate diagnosis, treatment and follow-up during childhood are essential for a better understanding of adult asthma and avoiding over- or under-treatment.Th2 inflammation in children with asthma symptoms is usually assessed by measuring with serum total IgE, blood eosinophilia and FeNO levels that may help to predict asthma, particularly in those infants and young children in whom lung function tests are difficult to perform. FeNO measurement, compared to intra-individual levels, may be useful also for ascertaining treatment adherence. Nevertheless, an isolated measurement may be insufficient and only the combination of these markers improves the diagnosis, phenotyping and follow-up of an asthmatic child.

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Section: Other Biomarkersmentioning

confidence: 99%

Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice

Sánchez‐García

Mena

Quirce

2017

European Clinical Respiratory Journal

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“…The reason for wheezing in atopic children with Adv pneumonia may be related to the exposure of the damaged airway epithelium neurons and increased airway sensitivity (20). Studies have shown that leukotriene E4 is strongly associated with episodes of acute wheezing in preschool children, and that higher levels of leukotriene E4 are present in the airways of atopic children than in the airways of nonatopic children (21); therefore, atopic children are more prone to wheezing. In contrast, it may also be related to the characteristics of Adv infection.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, Clinical Characteristics, and Prognostic Factors of Atopic Children Hospitalised for Adenovirus Infection: A Single Institutional Study in Shenyang, China

Han

Liu

et al. 2020

Preprint

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Background: Atopy may be associated with the severity of disease and poor prognosis after adenovirus (Adv) infection in children. Our aim was to observe the clinical characteristics and pulmonary radiological changes in atopic children with Adv pneumonia in China.Methods: Children hospitalised for Adv pneumonia from June 2018 to Dec 2019 were analysed. All children were divided into three groups: atopic with Adv, non-atopic with Adv, and atopic without Adv infection. Each group was further divided into mild or severe infection groups according to disease severity. Standard treatment was initiated after admission and regular follow-up evaluations were conducted at 1 month after discharge. Baseline and clinical characteristics, and pulmonary radiological changes of atopic and non-atopic children were collected. Risk factors associated with small airway diseases in Adv pneumonia patients were analyzed.Results: Compared with non-atopic children with Adv infection, the cases of eosinophilic granulocyte count were significantly higher in atopic children than non-atopic children (P<0.05). Among children with mild and severe infection, the number of patients with wheezing and small airway disease as observed by high-resolution computed tomography (HRCT) was significantly higher in atopic children than non-atopic children (P<0.05). Furthermore, coughing was more severe in atopic children than non-atopic children (P<0.05). A family history of asthma (OR 2.1 [95% CI 1.8–3.0]), personal history of asthma (OR 2.7 [95% CI 2.1–3.1]), atopy (OR 2.1 [95% CI 1.8–3.2]), severe infection (OR 1.9 [95% CI 1.0–2.7]), and Adv infection (OR 1.4, [95% CI 0.9–2.0]) were independent factors associated with the development of small airway disease, both after admission and a month after discharge. Conclusions: Atopic children with Adv infection experience more severe coughing during hospitalisation and are prone to wheezing and small airway disease on the HRCT. Family and personal history of asthma, atopy, severe infection, and Adv infection were independent factors associated with the development of small airway disease on the chest HRCT scan.

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“…A few studies have already been carried out in children to identify allergy markers in less invasive biologic fluids like urine and saliva . However, for both urine and saliva, one should be aware that analysis of biomarkers may run into some issues ranging from the fact that it does not reflect the source of the biomarker, the difficulty of adequate result expression, and method and timing of collection can have an enormous impact on the results.…”

Section: Biomarkers For Allergy In Other Biologic Fluidmentioning

confidence: 99%

Serum biomarkers for allergy in children

Knipping

Knippels

Dupont³

et al. 2016

Pediatric Allergy Immunology

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A large number of studies investigating various biomarkers for allergy have been published over the past decades. The aim of this review was to evaluate these biomarkers on their diagnostic and/or predictive value. To this date, no single or specific biomarker for allergy has been identified. As allergy is not one disease, but a collection of a number of allergic conditions, it is more plausible a combination of clinical history, clinical readouts, and diagnostic markers will be needed.

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Urinary leukotriene E4 levels in atopic and non-atopic preschool children with recurrent episodic (viral) wheezing: a potential marker?

Abstract: U-LTE4 is strongly associated with the acute wheeze episode in preschool children, more so in atopics. Increased basal levels of U-LTE4 occur only in atopics. This suggests a potential role of U-LTE4 as a marker of atopic, virus-induced asthma in preschool children.

Cited by 17 publications

References 25 publications

Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice

Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice

Epidemiology, Clinical Characteristics, and Prognostic Factors of Atopic Children Hospitalised for Adenovirus Infection: A Single Institutional Study in Shenyang, China

Serum biomarkers for allergy in children

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