Urinary leukotriene levels are increased during exacerbation of atopic eczema/dermatitis syndrome. Relation to clinical status

Abstract

Our results point to enhanced biosynthesis of Cys-LTs during the AEDS exacerbations. Inflammatory cells, e.g. eosinophils are the most probable source of Cys-LTs. A strong correlation between Cys-LT levels and clinical status may in part explain preliminary clinical observations of efficacy of leukotriene antagonists in alleviating symptoms of AEDS.

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

“…Although the role of cysteinyl LTs in the inflammation of AD is unclear, several reports in the literature, but not all (Veien et al, 2005), detail improvements in patients (adult and children) with moderate to severe AD with the use of LTRAs at the doses generally recommended for asthma treatment Leonardi et al, 2007;Broshtilova and Gantcheva, 2010). In support, there is also the evidence that elevated levels of LTE 4 have been found in the urine of patients with AD (Adamek-Guzik et al, 2002;Øymar and Aksnes, 2005). Chronic urticaria (CU) may manifest as an idiopathic reaction or as a reaction to a known cause, such as cold, pressure, food additives, or NSAIDs; however, this does not occur with selective COX-2 inhibitors (Zembowicz et al, 2003).…”

Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters

“…Patients were studied at three time‐points: during the exacerbation (day 0) and after 4 and 12 weeks of the treatment with oral antihistamine (cetirizine; purchased from UCB Pharma, Bulle, Switzerland) and topical steroid (mometasone; purchased from Schering–Plough AG, Heist‐op‐den Berg, Belgium) applied on lesional skin. At these time‐points skin, nose and throat were examined for the colonization with S. aureus , immunological tests were carried out, and clinical status was assessed using severity scoring of atopic dermatitis (SCORAD) as used before [24]. Clinical status was also additionally assessed in all patients 12 weeks after conclusion of the treatment.…”

“…The total IgE levels were determined in sera from AD patients by ELISA, using AlaSTAT total IgE test (DPC Biermann, Bad Neuheim, Germany) as described before [24]. Levels of total IgG, IgM and IgA were determined by nephelometry (Behring Nephelometer 100, Behring AG, Marburg, Germany).…”

Arachidonic Acid Signaling in Pathogenesis of Allergy: Therapeutic Implications

“…This increased urinary excretion appears to be correlated with the severity of skin lesions and eosinophil counts during exacerbation of the disease [49]. However, there are conflicting data since some authors have found that urine LTE 4 levels were not increased during or after the acute exacerbation of atopic dermatitis, compared with the normal range [50].…”