Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy

Abstract

Findings of the current study highlighted the underlying inflammatory process following extracorporeal shock wave lithotripsy (ESWL) procedure and can be a good sample for further investigations. Introduction: Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones. According to the growing utilization of ESWL as a major method of urinary stone, management and the reports have been reported based on renal tissue damage. Objectives: We decided to examine the severity of ESWL-induced renal tissue damage and its related factors by monitoring the urinary levels of cytokines. Patients and Methods: In this study, the urinary samples of 32 patients with urolithiasis were taken before, 24 hours and 14 days after ESWL and interleukin-1ɑ (IL-1a) and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Our findings indicated that there was a significant difference between the urinary levels of both IL-1ɑ and IL-6 in 14 days before and after ESWL. Conclusion: According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation have continuously increased up to 14 days after procedure. Please cite this paper as: