Urinary levels of organophosphate pesticides and predictors of exposure in pre-school and school children living in agricultural and urban communities from south Spain

Gónzalez-Alzaga, Beatriz; Romero-Molina, Desirée; López-Flores, Inmaculada; Giménez-Asensio, María José; Hernández, Antonio F.; Lacasaña, Marina

doi:10.1016/j.envres.2020.109459

Cited by 20 publications

(10 citation statements)

References 45 publications

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“…Although our study reports novel findings regarding the association of exposure to NEO insecticides with MCHC, it has some limitations. First, OPs are rapidly metabolised and their half-lives are relatively short; therefore, the concentrations of DAPs reflect recent exposure, predominantly in the previous few days (24-72 h) [78,79]. However, DAP concentrations reflect exposure to multiple OP insecticides and are widely used [79][80][81].…”

Section: Limitationsmentioning

confidence: 99%

“…First, OPs are rapidly metabolised and their half-lives are relatively short; therefore, the concentrations of DAPs reflect recent exposure, predominantly in the previous few days (24-72 h) [78,79]. However, DAP concentrations reflect exposure to multiple OP insecticides and are widely used [79][80][81]. NEOs have shorter half-lives than their metabolites, and we included NEO/m to represent a wide range of NEO exposures [82].…”

Section: Limitationsmentioning

confidence: 99%

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Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

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Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.

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Section: Limitationsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

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Section: Introductionmentioning

confidence: 99%

“…3 After absorption, OPs are metabolized into the more reactive oxon forms, which may bind to cholinesterases with their consequent inhibition, or be hydrolyzed into non-specific dialkylphosphate (DAP) metabolites, these are widely used as biological indicators of these compounds. 4,5 OPs can alter cell components such as lipids and proteins, as well as DNA through genotoxic damage and epigenetic modifications. [6][7][8][9][10][11] Epigenetic changes refer to chemical modifications of DNA or of the structural and regulatory proteins bound to it, which do not involve changes in nucleotide sequence and that are potentially transmissible to daughter cells.…”

Section: Introductionmentioning

confidence: 99%

Methylation patterns of the CDKN2B and CDKN2A genes in an indigenous population exposed to pesticides

et al. 2022

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The INK4 -ARF locus includes the CDKN2B and CDKN2A genes and is functionally relevant in the regulation of both cell proliferation and senescence. Studies have reported modifications of DNA methylation in this locus by exposure to environmental contaminants including pesticides; however, until now, specific methylation profiles have not been reported in genetically conserved populations exposed to occupational pesticides. The aim of this study was to determine the methylation profiles of the CDKN2B and CDKN2A genes in a genetically conserved population exposed to pesticides. A cross-sectional and analytical study was carried out in 190 Huichol indigenous persons. Information related to pesticide exposure, diet and other variables were obtained through the use of a structured questionnaire. Blood and urine samples were collected for methylation test and dialkylphosphates (DAP) determination, respectively. DNA methylation was measured by the pyrosequencing of bisulfite-treated DNA and DAP concentrations by gas chromatography-tandem mass spectrometry (GC/MS). The most frequent metabolite in the population was dimethylthiophosphate. The farmer group presented a higher methylation percentage of CDKN2B than the non-farmer group, but no differences in CDKN2A were observed between groups. A positive correlation between methylation of CpG site 3 of CDKN2B and time working in the field was observed in the farmer group. An association between methylation percentage of CDKN2B and age was also observed in the non-farmer group. These results suggest that pesticide exposure and exposure time in Huichol indigenous individuals could modify the methylation pattern of the CDKN2B gene.

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“…Recently, increasing numbers of epidemiological studies have demonstrated the impacts of OPPs on neurodevelopment in children [ 3 , 4 , 5 ] and via prenatal exposure [ 6 ]. Some studies reported that human exposure to OPPs is associated with the season; intake of certain food items, such as vegetables (tomato and sweet pepper), fruits (apple, banana, citrus, kiwi and apricot), beans, bread and drinking water; and the use of pesticides in workplaces [ 7 , 8 , 9 ]. Similar results were obtained from large-scale birth cohort studies [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Nishihama

Nakayama

Isobe

et al. 2021

IJERPH

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Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10.

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Urinary levels of organophosphate pesticides and predictors of exposure in pre-school and school children living in agricultural and urban communities from south Spain

Cited by 20 publications

References 45 publications

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Methylation patterns of the CDKN2B and CDKN2A genes in an indigenous population exposed to pesticides

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

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