Urinary levels of phthalate metabolites in women associated with risk of premature ovarian failure and reproductive hormones

Cao, Mingkai; Pan, Weiqiang; Shen, Xinyi; Li, Chunming; Zhou, Jianhong; Liu, Jing

doi:10.1016/j.chemosphere.2019.125206

Cited by 55 publications

(22 citation statements)

References 33 publications

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“…We also observed similar unadjusted GM MEP concentrations in our hairdressers compared to those reported among a group of 26 nail salon workers (143.9 ng/mL vs 140.0 ng/mL) who were predominantly female (65%) and of Asian descent (88%), while they were five times lower than those reported in another study in a group of 17 Vietnamese nail salon workers, the majority of whom were female (88%) . Compared to two other studies among nonpregnant women of reproductive age, hairdressers in our study had 2.3 to 40.5 times higher uncorrected median MEP concentrations (122.7 ng/mL). , Specifically, in a case-control study among Chinese women aged 16–45 years, Cao et al reported a median MEP concentration of 3.0 and 3.3 μg/L among 173 women with premature ovarian failure and 246 control women, respectively; Hauser et al reported a median MEP concentration of 52.2 μg/L among 256 US women undergoing in vitro fertilization . Similarly, compared to studies that reported GM values among women of reproductive age, we observed higher GM MEP concentrations among hairdressers in our study. ,, For example, specific gravity-corrected GM MEP concentrations were seven times higher among hairdressers compared to a sample of Latino adults, the majority of which were female .…”

Section: Resultssupporting

confidence: 80%

“…48 Compared to two other studies among nonpregnant women of reproductive age, hairdressers in our study had 2.3 to 40.5 times higher uncorrected median MEP concentrations (122.7 ng/mL). 49,50 Specifically, in a case-control study among Chinese women aged 16−45 years, Cao et al reported a median MEP concentration of 3.0 and 3.3 μg/L among 173 women with premature ovarian failure and 246 control women, respectively; 49 Hauser et al reported a median MEP concentration of 52.2 μg/L among 256 US women undergoing in vitro fertilization. 50 Similarly, compared to studies that reported GM values among women of reproductive age, we observed higher GM MEP concentrations among hairdressers in our study.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Occupational Exposures to Phthalates among Black and Latina U.S. Hairdressers Serving an Ethnically Diverse Clientele: A Pilot Study

Boyle

Kavi

Louis

et al. 2021

Environ. Sci. Technol.

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Hairdressers may be differentially exposed to phthalates through hair salon services provided and products used, yet no U.S. studies have investigated these exposures in this population. We characterized concentrations and exposure determinants to nine phthalate metabolites in postshift urine samples among 23 hairdressers from three Black and three Dominican salons, as well as a comparison group of 17 female office workers from the Maryland/Washington D.C. metropolitan area. Overall, hairdressers had higher metabolite concentrations than office workers. The geometric mean (GM) for monoethyl phthalate (MEP) was 10 times higher in hairdressers (161.4 ng/mL) than office workers (15.3 ng/mL). Hairdressers providing select services and using certain products had higher GM MEP concentrations than those who did not: permanent waves/texturizing (200.2 vs 115.4 ng/mL), chemical straightening/relaxing (181.6 vs 92.1 ng/mL), bleaching (182.3 vs 71.6 ng/mL), permanent hair color (171.9 vs 83.2 ng/mL), and Brazilian blowout/keratin treatments (181.4 vs 134.6 ng/mL). Interestingly, hairdressers providing natural services had lower GM MEP concentrations than those who did not: twists (129.1 vs 215.8 ng/mL), sister locs/locs (86.0 vs 241.9 ng/mL), and afros (94.7 vs 203.9 ng/mL). Larger studies are warranted to confirm our findings and identify disparities in occupational phthalate exposures.

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Section: Resultssupporting

confidence: 80%

Section: ■ Results and Discussionmentioning

confidence: 99%

Occupational Exposures to Phthalates among Black and Latina U.S. Hairdressers Serving an Ethnically Diverse Clientele: A Pilot Study

Boyle

Kavi

Louis

et al. 2021

Environ. Sci. Technol.

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“…This can explain the negative correlation between estrogen and MEHP levels that have been found in the present study (p < 0.001) with regard to Groups A and B. Similarly, Cao et al have examined the urinary levels of phthalate metabolites as well as the serum levels of ovarian hormones, and have discovered that the estrogen to FSH ratio (an indicator of the ovarian reserve) was significantly and adversely linked with urine levels of most phthalate end products in control women [49].…”

Section: Mehp and Mehhp Have Been Previouslysupporting

confidence: 77%

Association of Phthalate Exposure with Endometriosis and Idiopathic Infertility in Egyptian Women

EL-Desouky

Elyamany²,

Hanon³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Phthalates are compounds found in medical supplies, cellophane wraps, beverage containers, metal can linings, and other products. They have the potential to be significant endocrine disruptors. In experimental animals, thereby affecting their reproductive capacity. Endometriosis is a gynecological condition defined by ectopic endometrial glands and stromal development. Exposure to phthalates has been linked to the development of endometriosis in numerous studies. The dangers of phthalates to women’s reproductive health and fertility have been widely reported. AIM: So far, the relationship between phthalates and infertility is not proven so we decided to see if there was a link between the urine phthalate metabolite levels and endometriosis or idiopathic infertility in Egyptian women. METHODS: Our research was carried out at the infertility outpatient clinic of the Faculty of Medicine of Cairo University. It included 100 female subjects aged 18−40-years-old. Group A (idiopathic infertility; n = 40), Group B (endometriosis; n = 40), and Group C (control; n = 20) were the three age-matched groups that were studied. Using high-performance liquid chromatography (HPLC), the urine levels of mono-2-ethylhexyl phthalate (MEHP) were quantified. RESULTS: The comparison between the study groups has revealed statistically significant differences regarding the urine MEHP levels between Groups A and B. An analysis of the urine MEHP levels in the study Groups A and B has also revealed that the significantly higher urinary MEHP levels are correlated with the use of dietary plastic containers, the use of cosmetics, and the patients’ estrogen levels. Moreover, the urinary MEHP levels of Group A were associated with a history of abortions. CONCLUSIONS: Higher levels of urinary MEHP are positively associated with female reproductive disorders, specifically endometriosis, idiopathic infertility, and abortion.

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“…Moreover, this study concluded that urinary phthalate concentration (namely MiBP) was negatively related to the oestrogen concentration and positively related to the FSH concentration. Thus, this study suggests that exposure to phthalates may be enough to decrease ovarian oestrogen production and consequently increase FSH production by positive feedback (Cao et al, 2020).…”

Section: Primary Ovarian Insufficiencymentioning

confidence: 72%

Update about the disrupting‐effects of phthalates on the human reproductive system

Mesquita

Lorigo

Cairrão

2021

Molecular Reproduction Devel

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Phthalate esters are synthetic chemicals used in the plastic industry as plasticizers and consumable products. According to United Nations, about 400 million tons of plastic are produced every year. In parallel with increased production, the concerns about its effects on human health have increased because phthalates are endocrinedisrupting compounds. Humans are continuously exposed to phthalates through different routes of exposure. Experimental data have associated the phthalates exposure to adverse effects on development and reproduction in women (e.g., earlier puberty, primary ovarian insufficiency, endometriosis, preterm birth, or in vitro fertilization) and men (e.g., anogenital distance, cryptorchidism, hypospadias, and changes in adult reproductive function) although there is no consensus. Therefore, one question arises: could the increase in infertility be related to phthalates exposure? To answer this question, we aimed to assess the disruptingeffects of phthalates on the human reproductive system. For this, we reviewed the current literature based on epidemiological and experimental data and experimental studies in humans. The phthalate effects were discussed in a separate mode for female and male reproductive systems. In summary, phthalates induce toxicity in the reproductive system and human development. The increased plastic production may be related to the increase in human infertility.

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Urinary levels of phthalate metabolites in women associated with risk of premature ovarian failure and reproductive hormones

Cited by 55 publications

References 33 publications

Occupational Exposures to Phthalates among Black and Latina U.S. Hairdressers Serving an Ethnically Diverse Clientele: A Pilot Study

Occupational Exposures to Phthalates among Black and Latina U.S. Hairdressers Serving an Ethnically Diverse Clientele: A Pilot Study

Association of Phthalate Exposure with Endometriosis and Idiopathic Infertility in Egyptian Women

Update about the disrupting‐effects of phthalates on the human reproductive system

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