Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle‐Aged Men

Abstract

The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC.

Different Intestinal Microbial Profile in Over-Weight and Obese Subjects Consuming a Diet with Low Content of Fiber and Antioxidants

“…In line with previous evidence from other authors, an association between obesity and higher serum concentrations of leptin [ 35 ], MDA [ 3 , 36 ], CRP [ 3 ] and glucose was corroborated in our study. However, our work also provides novel insight into the differences found in some intestinal bacterial groups related to BMI and obesity-associated oxidative stress and inflammation in the general population.…”

Quantification of Malondialdehyde in Human Urine by HPLC‐DAD and Derivatization with 2,4‐Dinitrophenylhydrazine

“…In our study on four male and four female, the mean urine level of MDA was 1.3 AE 0.6 μg/mg creatinine. This value is similar with previously reported values of 0.08 AE 0.03 μg/mg creatinine in human urine, 13 0.06 AE 0.01 μg/mg creatinine in rat urine, 5 0.07 AE 0.03 μg/mg in serum, 7 0.11 AE 0.06 μg/mg creatinine in human urine, 11 and 0.01 AE 0.01 μg/mg creatinine in human urine. 26 Estimation of MDA is commonly used for monitoring lipid peroxidation of MDA in biological samples.…”

“…Because of these advantages, urinary MDA has been widely used in the several study reported as a noninvasive biomarker of lipid peroxidation induced oxidative damage. 26,34 It is associated with many disease such as visceral abdominal obesity, 11 preeclampsia, 29 postterm delivery, 34 and smoking. 13 Like these studies, research for determination of MDA have been conducted as various methods.…”

“…1 For the past decades, MDA has been widely studied as an experimental or diagnostic index of peroxidative tissue injury. [1][2][3]6 According to large number of studies, many diseases such as asthma, 6 Sikkimese diabetics, 7 prostate cancer, 8 coronary artery disease, 9 atheroma, 10 visceral abdominal obesity, 11 acute pancreatitis, 12 smoking, 13 and pulmonary diseases 14 were known to be associated with increased oxidative stress, depending on the extent of shift either mild or severe. 15 Measurement of MDA have crucial role in the assessment of oxidative stress.…”

Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus

“…Malondialdehyde (MDA) is reported to be a primary biomarker of lipid peroxidation of poly-unsaturated fatty acids that were attacked by ROS [25,27] inducing multiple cellular alterations, influencing on the activity of mitochondrial respiratory chain, and generating more ROS, thus further increasing oxidative stress in NAFLD [18] and making a vitious circle between oxidative stress and NAFLD.…”