Urinary Markers of Oxidative Dna Damage in Type 1 Diabetic Children: Relation to Microvascular Complications

Wakeel, Maged A. El; Abou-El-Asrar, Mohamed; El-Kassas, Ghada M.; Elabd, Mona A.; Zeid, Dina Abu; Sabry, Rania N.; Awadallah, Eman

doi:10.22159/ajpcr.2017.v10i10.18930

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Diabetic overweight and obese children were significantly 3.8 folds more at risk to be bad glycemic control than diabetic children with normal BMI. This result comes in line with that of El-Wakeel et al's study [42]; this strong association was confirmed by many other studies [8], [18].…”

Section: Figure 2: Correlation Between Body Mass Index and Interleukisupporting

confidence: 92%

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Abdelhamid

Kamhawy

Ahmed

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Obesity is an expanded health problem worldwide and it is blamed for a startling rise in type 1 diabetes (T1DM), the interaction between obesity, autoimmune processes, and glucose homeostasis is a growing field of study. AIM: This study was undertaken to predict the role of the inflammatory cytokines (interleukin [IL]-17 and IL-10) as biomarkers in early screening for obesity and T1DM and to determine the relation of inflammatory cytokines with diabetic complications especially nephropathy. SUBJECTS AND METHODS: The target group consisted of 92 children with type 1 diabetes children who were diagnosed according to the criteria provided by American Diabetes Association Diabetic; cases were divided into two groups, Group 1 (overweight and obese diabetics) and Group 2 (normal weight diabetic children). The levels of serum IL-17 and IL-10 were assayed in these children by an enzyme-linked immunosorbent assay. Serum triglycerides (TG) and cholesterol levels were measured as well as urinary microalbumin level was estimated for detection of nephropathy. RESULTS: Diabetic overweight and obese children exhibited significantly 3.8 folds more at risk to be bad glycemic control than diabetic children with normal body mass index (BMI). Furthermore, overweight and obese diabetic children displayed significantly 15 times more at risk of having nephropathy than diabetic children with normal BMI. Low serum level of IL 10 and high level of IL 17 showed a significant association with high BMI in diabetic children. High HBA1c, low IL 10, and long disease duration were significantly considered as predominant risk factors for diabetic nephropathy in diabetic children. CONCLUSION: The obtained data from these investigations proved that overweight and obese children have a low serum level of IL-10 and high serum IL-17 levels. The relationship between IL-10/IL-17 can be applied as a good marker for the inflammatory state and these inflammatory interleukins can be employed as biomarkers in early screening for obesity and T1DM. Furthermore, these interleukins can be utilized as a predictor for early diabetic complications, particularly nephropathy.

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Section: Figure 2: Correlation Between Body Mass Index and Interleukisupporting

confidence: 92%

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Abdelhamid

Kamhawy

Ahmed

et al. 2020

Open Access Maced J Med Sci

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“…Type 1 diabetes mellitus (T1DM) is one of the most common pediatric chronic diseases, in which a progressive autoimmune T cell-mediated β cell destruction of pancreatic islets in genetically susceptible individuals (Wang et al 2017), resulting in loss of insulin secretion (Larsson et al 2016). Numerous studies have reported an increasing incidence of type 1 diabetes in children worldwide (Patterson et al 2015;El Wakeel et al 2017;Sabry et al 2018). It has major health consequences for individuals and societies.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life in a group of Egyptian children and adolescents with type 1 diabetes: relationship to microvascular complications

et al. 2019

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Background: The increased prevalence of type 1 diabetes mellitus in children and adolescents with its complications, especially microvascular ones (retinopathy, nephropathy, and neuropathy) that affect the expectancy of their lives, besides imposing restrictions on their physical, emotional, and social functioning, adversely affecting their quality of life, in turn would lead to worsening of their compliance and adherence to the treatment with subsequent hazards on metabolic control, development, and progression of adverse diabetic complications that might cause multiple organ damage and impose more disease burden and impact the quality of life of the growing young diabetics and their families. Aim: The aim of the present study was to assess health-related quality of life of a group of Egyptian children and adolescents with type 1 diabetes in addition to investigate the relation of microvascular complications and other sociodemographic and clinical indicators to their quality of life.

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“…Patients with greater urine 8-oxodG levels had significantly faster development of diabetic kidney disease, according to clinical trial with a 5-year follow-up [56]. It has been shown that urinary 8-oxodG has a pathogenic role in the development of diabetic retinopathy in patients with both T1DM and T2DM [57]. According to Etiane et al, 8-oxodG has an AUC of 0.836, making it a diagnostic tool for assessing microvascular problems in diabetes patients [58].…”

Section: Biomarker Of Oxidative Stressmentioning

confidence: 99%

Early Laboratory biomarkers for the Quick Detection of Diabetic kidney Disease

2024

J Urol Ren Dis

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The significance of early identification of Diabetic Kidney Disease (DKD), a significant complication leading to End-Stage Kidney Disease (ESKD), is highlighted by the increasing frequency of diabetes worldwide. Using search phrases such as "diabetic kidney disease," "early biomarkers," and "laboratory markers," this study synthesizes material from PubMed, Medline, and Google Scholar to examine early laboratory biomarkers for quick Diabetic Kidney Disease (DKD) identification. The ability to detect early DKD is limited by the use of conventional markers such as albuminuria and Estimated Glomerular Filtration Rate (eGFR). Reflecting the underlying inflammatory processes, inflammatory biomarkers such as Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor Necrotic Factor-Alpha (TNF-α) have emerged as possible early indications of DKD development and progression. Furthermore, tubular damage-related indicators including Kidney Injury Molecule-1 (KIM-1) and Vitamin D-Binding Protein (VDBP) have the potential to identify early renal impairment. Beta-2 Microglobulin (B2M) and urine type IV collagen are examples of glomerular damage indicators that are linked to structural abnormalities in DKD, which may help with early identification. Pentosidine and the oxidized DNA nucleoside 8-oxodG are two examples of oxidative stress indicators that show promise in predicting macrovascular and microvascular problems in DKD. These biomarkers provide light on the etiology and course of DKD, giving medical professionals useful instruments for prompt intervention and treatment.

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Urinary Markers of Oxidative Dna Damage in Type 1 Diabetic Children: Relation to Microvascular Complications

Cited by 5 publications

References 29 publications

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Health-related quality of life in a group of Egyptian children and adolescents with type 1 diabetes: relationship to microvascular complications

Early Laboratory biomarkers for the Quick Detection of Diabetic kidney Disease

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