2023
DOI: 10.3390/life13020343
|View full text |Cite
|
Sign up to set email alerts
|

Urinary Markers of Tubular Injury and Renal Fibrosis in Patients with Type 2 Diabetes and Different Phenotypes of Chronic Kidney Disease

Abstract: This study assessed the urinary excretion of markers and mediators of tubular injury and renal fibrosis in patients with type 2 diabetes (T2D) and non-albuminuric and albuminuric patterns of chronic kidney disease (CKD). One hundred and forty patients with long-term T2D and different patterns of CKDand twenty non-diabetic individuals were included. Urinary retinol-binding protein 4 (RBP-4), glutathione-S-transferase α1 and π (GST-α1 and GST-π), transforming growth factor β (TGF-β), type I and type IV collagen … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 63 publications
0
2
0
Order By: Relevance
“…Moreover, the levels of RBP-4 were found to be elevated in the DN group relative to the NDN group. RBP-4 exhibited positive correlations with UACR, CysC, Scr, urea, UTP/24 h, and the NLR, and a negative correlation with the eGFR, making it a reliable indicator of kidney functions[ 28 ]. With a molecular weight of 21 kDa, RBP-4 is predominantly found in insulin-responsive tissues, including skeletal muscle and adipose tissue.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the levels of RBP-4 were found to be elevated in the DN group relative to the NDN group. RBP-4 exhibited positive correlations with UACR, CysC, Scr, urea, UTP/24 h, and the NLR, and a negative correlation with the eGFR, making it a reliable indicator of kidney functions[ 28 ]. With a molecular weight of 21 kDa, RBP-4 is predominantly found in insulin-responsive tissues, including skeletal muscle and adipose tissue.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, we did not examine urine creatinine concentration. The urine protein creatinine ratio has been considered an important parameter for predicting proteinuria [ 49 , 50 , 51 ], which needs to be included in our further study on lupus nephritis.…”
Section: Discussionmentioning
confidence: 99%