Urinary metabolites of flavonoids and hydroxycinnamic acids in humans after application of a crude extract from Equisetum arvense

Graefe, Eva Ulrike; Veit, Markus

doi:10.1016/s0944-7113(99)80015-4

Cited by 57 publications

(31 citation statements)

References 29 publications

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“…It has been well established that various types of constituents, such as saponins, organic acids and phenolic compounds may dictate diuretic activity of extracts. Diuretic effect of flavonoids (Graefe & Veit, 1999;Makarov, 1972) and their glycosides (Borkowski, 1960), e.g., luteolin (Compaore et al, 2011), hesperidin (Galati et al, 1996;Garg et al, 2001) and isoquercitin (Gasparotto et al, 2011) have been demonstrated in a number of reports. High diuretic potency of the V. vitis-idaea extract can be reasonably attributed to substantial content of arbutin in this extract.…”

Section: Discussionmentioning

confidence: 99%

Diuretic activity and toxicity of someVerbascum nigrumextracts and fractions

Kalinina

Elkina

Kalinin

et al. 2013

Pharmaceutical Biology

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Context: Verbascum nigrum L. (Scrophulariaceae) is a perennial plant used in folk medicine for the treatment of kidney diseases due to its presumable diuretic properties. Objective: We investigated the diuretic activity and toxicity of extracts from different parts of V. nigrum and identified a group of compounds responsible for the biological effect. Materials and methods: Five ethanol extracts from herb, roots, flowers, leaves and stems as well as five fractions of polar compounds isolated from herb of V. nigrum were orally administrated as a single dose of 50 mg/kg to rats. Urinary excretion and electrolyte content were measured at 3 and 6 h after the treatment. The acute toxicity of the V. nigrum extracts and fractions was evaluated in mice. Results: All extracts, except the one prepared from the roots, showed a significant increase of the urine output within first 3 h after their administration. The extract from stems was the most active, inducing urine output of 14.6 AE 0.8 ml/kg BW versus 5.2 AE 1.4 ml/kg BW of the control. It also demonstrated saluretic activity with a natriuretic index 4.1 and a kaliuretic index 3.8. The diuretic activity was correlated with the flavonoid content in the plant organs. Flavonoid fractions demonstrated significant activity; the higher content of flavonoids (expressed as hesperidin) translated into more pronounced diuretic (35.9 AE 2.1 ml/kg BW) and saluretic effects (natriuretic index 4.5 and kaliuretic index 5.4). Conclusion: The diuretic activity of traditionally used V. nigrum was validated experimentally. The pharmacological effect was attributed to flavonoids, which accumulated in aerial parts of the plant, mainly in stems.

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Section: Discussionmentioning

confidence: 99%

Diuretic activity and toxicity of someVerbascum nigrumextracts and fractions

Kalinina

Elkina

Kalinin

et al. 2013

Pharmaceutical Biology

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“…Quercetin is quickly transformed to rutin in the body, and the turnover of rutin is rapid (Graefe and Veit 2000). Since there was a 21 times higher level of rutin equivalents in the TBW, and intake of rutin equivalents from CBW was of the same order of magnitude as the average daily intake in a Nordic country, we considered the blinded cross-over design as a suitable study design to study the effect of rutin, which was the main aim.…”

Section: Discussionmentioning

confidence: 99%

Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Wieslander

Fabjan

Vogrincic

et al. 2011

Tohoku J. Exp. Med.

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Buckwheat food is a good source of antioxidants, e.g. rutin, and other beneficial substances. Here we investigated the effects of the intake of common buckwheat (low rutin content) and tartary buckwheat cookies (high rutin content) on selected clinical markers. A double blind crossover study was performed among female day-care centre staffs (N = 62) from five day-care centres. Participants were randomly divided into two groups. The first group initially consumed four common buckwheat cookies per day (16.5 mg rutin equivalents/day) for two weeks, while the second group consumed four tartary buckwheat cookies per day (359.7 mg rutin equivalents/day). Then the groups switched their type of cookies and consumed them for another two weeks. We monitored selected clinical markers related to cardiovascular disease and lower airway inflammation, lung function, and subjective breathing difficulties in the staffs. Intake of tartary buckwheat cookies reduced the serum level of myeloperoxidase (MPO) by a factor 0.84 ( p = 0.02). When grouping the two types of buckwheat cookies together, there was a reduction of total serum cholesterol ( p < 0.001) and HDL-cholesterol ( p < 0.001) during the study period, with improved lung vital capacity ( p < 0.001). The degree of reduction in total and HDL cholesterol levels was similar in staffs with low and high body mass index (cut off 25). In conclusion, intake of tartary buckwheat cookies with high level of the antioxidant rutin may reduce levels of MPO, an indicator of inflammation. Moreover, intake of both types of buckwheat cookies may lower cholesterol levels.Keywords: antioxidant experiment; buckwheat; cholesterol; inflammation; lung function Tohoku J. Exp. Med., 2011, 225 (2), 123-130. © Tohoku University Medical PressThere is an increased interest in the beneficial health effects of dietary antioxidants intake, because they can help to prevent different types of diseases. Buckwheat is a good source of antioxidants, biologically high-valued amino acids (Krkoškova and Mrazova 2005;Jiang et al. 2007), dietary fiber (Bonafaccia et al. 2003), and minerals such as zinc, copper and manganese (Ikeda and Yamashita 1994). In Shanxi province, China, both common (Fagopyrum esculentum) and tartary (Fagopyrum tataricum) buckwheats are used to improve the health of patients with diabetes and cardiovascular diseases (Wieslander et al. 2000). A previous experimental buckwheat study concluded that intake of common buckwheat leaf tea could prevent further development of leg edema (Ihme et al. 1996), and a study by He et al. (1995) showed a cholesterol-lowering effect of buckwheat. However, there are very few studies on the health effects of buckwheat, especially buckwheat products in humans. Japanese studies indicate that some of the beneficial effects of buckwheat may be related to the low digestibility of buckwheat (Ikeda and Yamashita 1994). Skrabanja et al. (2001) reported beneficial effects of starch in common buckwheat with respect to insulin response. Buckwheat is also a good source of r...

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“…Hung.). Horsetail preparations have effects on diuresis (Graefe and Veit, 1999) and are antioxidant (Trouillas et al, 2003), vasorelaxant (Sakurai et al, 2003) antinociceptive, antiinflammatory (Martins et al, 2004) and possess germination inhibitory activity (Hiraga et al, 1997).…”

Section: Equisetum Arvense L (Equisetaceae Subgenusmentioning

confidence: 99%

Composition and antimicrobial activity ofEquisetum arvense L. essential oil

2006

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The volatile constituents of the sterile stems of Equisetum arvense L. (Equisetaceae) were investigated for the first time using GC, GC/MS and (13)C-NMR. Twenty-five compounds were identified. Hexahydrofarnesyl acetone (18.34%), cis-geranyl acetone (13.74%), thymol (12.09%) and trans-phytol (10.06%) were the major constituents. A disk diffusion method was used for the evaluation of the antimicrobial activity of this oil against a panel of microorganisms (bacteria: Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteritidis; fungi: Aspergillus niger and Candida albicans). The 1:10 dilution of the essential oil of Equisetum arvense L. was shown to possess a broad spectrum of a very strong antimicrobial activity against all tested strains.

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Urinary metabolites of flavonoids and hydroxycinnamic acids in humans after application of a crude extract from Equisetum arvense

Cited by 57 publications

References 29 publications

Diuretic activity and toxicity of someVerbascum nigrumextracts and fractions

Diuretic activity and toxicity of someVerbascum nigrumextracts and fractions

Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Composition and antimicrobial activity ofEquisetum arvense L. essential oil

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