Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using 1 H NMR analysis

Wu, Fang; Zheng, Heng; Yang, Zheng-Teng; Cheng, Bang; Wu, Jinxia; Liu, Xu-wen; Tang, Chaoling; Lu, Shiyin; Chen, Zhao-Ni; Song, Fangming; Ruan, Junxiang; Zhang, Hongye; Liu, Yonghong; Song, Hui; Su, Zhiheng

doi:10.1016/j.jpba.2017.03.031

Cited by 33 publications

(20 citation statements)

References 28 publications

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“…The genus Corydalis is an important group of Papaveraceae. Corydalis plants contain a variety of alkaloid components that possess potent pharmacological effects, including antinociceptive (Wang et al, ), anticardiovascular (Hung & Wu, ), antitumor (Gao, He, Li, & Wang, ), antidepressive (Du et al, ), hepatoprotective (Wu et al, ), acetylcholinesterase inhibitory, and butyrylcholinesterase inhibitory effects (Orhan, Şener, Choudhary, & Khalid, ). More than 30 species are used in folk medicine or are recorded in the Pharmacopoeia (Pharmacopoeia Commission of People's Republic of China, ; Sang, ), and these species are often closely related.…”

Section: Discussionmentioning

confidence: 99%

“…The genus Corydalis is an important group of Papaveraceae. Corydalis plants contain a variety of alkaloid components that possess potent pharmacological effects, including antinociceptive , anticardiovascular (Hung & Wu, 2016), antitumor (Gao, He, Li, & Wang, 2009), antidepressive (Du et al, 2018), hepatoprotective (Wu et al, 2017), acetylcholinesterase inhibitory, and butyrylcholinesterase inhibitory effects (Orhan, Şener, Choudhary, & Khalid, 2004).…”

Section: Potential Utility Of Dna Barcoding In Corydalismentioning

confidence: 99%

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DNA barcoding of Corydalis, the most taxonomically complicated genus of Papaveraceae

Ren

Wang

et al. 2019

Ecology and Evolution

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The genus Corydalis is recognized as one of the most taxonomically challenging plant taxa. It is mainly distributed in the Himalaya–Hengduan Mountains, a global biodiversity hotspot. To date, no effective solution for species discrimination and taxonomic assignment in Corydalis has been developed. In this study, five nuclear and chloroplast DNA regions, ITS, ITS2, matK , rbcL , and psbA‐trnH , were preliminarily assessed based on their ability to discriminate Corydalis to eliminate inefficient regions, and the three regions showing good performance (ITS, ITS2 and matK ) were then evaluated in 131 samples representing 28 species of 11 sections of four subgenera in Corydalis using three analytical methods (NJ, ML, MP tree; K2P‐distance and BLAST). The results showed that the various approaches exhibit different species identification power and that BLAST shows the best performance among the tested approaches. A comparison of different barcodes indicated that among the single barcodes, ITS (65.2%) exhibited the highest identification success rate and that the combination of ITS + matK (69.6%) provided the highest species resolution among all single barcodes and their combinations. Three Pharmacopoeia‐recorded medicinal plants and their materia medica were identified successfully based on the ITS and ITS2 regions. In the phylogenetic analysis, the sections Thalictrifoliae , Sophorocapnos , Racemosae , Aulacostigma , and Corydalis formed well‐supported separate lineages. We thus hypothesize that the five sections should be classified as an independent subgenus and that the genus should be divided into three subgenera. In this study, DNA barcoding provided relatively high species discrimination power, indicating that it can be used for species discrimination in this taxonomically complicated genus and as a potential tool for the authentication of materia medica belonging to Corydalis .

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Section: Discussionmentioning

confidence: 99%

“…The genus Corydalis is an important group of Papaveraceae. Corydalis plants contain a variety of alkaloid components that possess potent pharmacological effects, including antinociceptive , anticardiovascular (Hung & Wu, 2016), antitumor (Gao, He, Li, & Wang, 2009), antidepressive (Du et al, 2018), hepatoprotective (Wu et al, 2017), acetylcholinesterase inhibitory, and butyrylcholinesterase inhibitory effects (Orhan, Şener, Choudhary, & Khalid, 2004).…”

Section: Potential Utility Of Dna Barcoding In Corydalismentioning

confidence: 99%

DNA barcoding of Corydalis, the most taxonomically complicated genus of Papaveraceae

Ren

Wang

et al. 2019

Ecology and Evolution

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“…Pharmacological studies have shown its effective antibacterial, antiviral, and anticancer activities (Wu et al, ; Xu, ). Recently, there has been increasing attention to its remarkable hepatoprotective effects against acute jaundice, chronic slight to severe hepatitis, cirrhosis, and even hepatoma (Wu et al, ). It is well acknowledged that the aforementioned benefits of CSB are mainly attributed to its active ingredients, the total alkaloids of CSB (Huang et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Corydalis saxicola Bunting (Yanhuanglian, CSB, Fumariaceae), as a well-known traditional Chinese medicine (TCM) in south China, has scattered stasis detumescence, heat-clearing, detoxification, and hemostatic effects (Li et al, 2008; Wei, Jiang, Jiang, Qi, & Tang, toprotective effects against acute jaundice, chronic slight to severe hepatitis, cirrhosis, and even hepatoma (Wu et al, 2017). It is well acknowledged that the aforementioned benefits of CSB are mainly attributed to its active ingredients, the total alkaloids of CSB (Huang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory and inductive effects of Corydalis saxicola Bunting total alkaloids (CSBTA) on cytochrome P450s in rats

Liu

et al. 2018

Phytotherapy Research

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Corydalis saxicola Bunting, a well-known traditional Chinese medicine in south China, has been widely used for the treatment of various hepatic diseases. Its active ingredients are Corydalis saxicola Bunting total alkaloids (CSBTA), which primarily include dehydrocavidine, palmatine, and berberine. These representative alkaloids could be metabolized by hepatic CYP450s. Hence, it is necessary to investigate the potential influences of CSBTA on CYP450s to explore the possibility of herb-drug interactions. In present study, in vitro inhibition and in vivo induction studies were performed to evaluate the potential effects of CSBTA extract on CYP450s in rats. Inhibition assay illustrated that CSBTA exerted inhibitory effects on CYP1A2 (IC , 38.08 μg/ml; K , 14.3 μg/ml), CYP2D1 (IC , 20.89 μg/ml; K , 9.34 μg/ml), CYP2C6/11 (IC for diclofenac and S-mephenytoin, 56.98 and 31.59 μg/ml; K 39.0 and 23.8 μg/ml), and CYP2B1 (IC , 48.49 μg/ml; K , 36.3 μg/ml) in a noncompetitive manner. Induction study showed CSBTA had obvious inhibitory rather than inductive effects on CYP1A2 and CYP2C6/11. Interestingly, neither inhibition nor induction on CYP3A was observed for CSBTA. In conclusion, CSBTA-drug interactions might occur through CYP450s inhibition, particularly CYP1A and CYP2D. Further studies are still needed to elucidate the underlying mechanisms of inhibition.

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“…& Thomson (Fumariaceae) is a wild herb and its roots are reported for topical use as hair tonic. 1 In literature, Corydalis species and/or its active principles have been reported for a number of activities such as antithrombotic, anticoagulant, 2 hepatoprotective, [3][4] neuroprotective, 5 antitumor, 6 antiinflammatory, 7 antinoceptive, 8 analgesic, 9 and antimalarial 10 etc. Various compounds like phenylpropanoid amides, 11 lignanamides, 6 flavonoid glycosides, 12 triterpenoids, 13 have been isolated from different Corydalis species.…”

Section: Introductionmentioning

confidence: 99%

GC-MS Analysis of Phytoconstituents in Fractions of Corydalis adiantifolia

Ali¹,

Khan²,

Khan³

et al. 2018

TJNPR

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Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using 1 H NMR analysis

Cited by 33 publications

References 28 publications

DNA barcoding of Corydalis, the most taxonomically complicated genus of Papaveraceae

DNA barcoding of Corydalis, the most taxonomically complicated genus of Papaveraceae

Inhibitory and inductive effects of Corydalis saxicola Bunting total alkaloids (CSBTA) on cytochrome P450s in rats

GC-MS Analysis of Phytoconstituents in Fractions of Corydalis adiantifolia

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