Urinary methylmalonic acid levels in patients with acute ischemic stroke

Kara, Niyazi Nefi; Şeneş, Mehmet; Coşkun, Özlem; İnan, Levent Ertuğrul; Saydam, Gülsevim; Yücel, Doğan

doi:10.1016/j.clinbiochem.2009.02.018

Cited by 5 publications

(6 citation statements)

References 31 publications

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“…Only articles rated good are reported on and discussed in this article. Studies rated fair 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 and poor 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95…”

Section: Resultsmentioning

confidence: 99%

Hyperhomocysteinemia and Ischemic Stroke: A Potential Dose-Response Association—A Systematic Review and Meta-analysis

Holmen

Hvas

Arendt

2021

TH Open

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Background and Purpose Previous studies suggest an association between increased homocysteine (Hcy) and risk of ischemic stroke. Yet, it remains unknown whether a dose-response association exists between Hcy levels and risk of ischemic stroke. Methods Systematic literature searches were performed in PubMed, Embase, Scopus, and Web of Science. Inclusion criteria were studies investigating ischemic stroke risk in an adult population with measured Hcy levels. We computed odds ratios (ORs) for a 5 µmol/L increase in Hcy levels using a random effects meta-analysis. Results In total, 108 studies met the inclusion criteria of which 22 were rated as high-quality studies, and 20 studies included a dose-response analysis. Hcy levels were analyzed either as a continuous or categorical variable. The majority of the studies found an increased risk of ischemic stroke when comparing the highest-to-lowest Hcy strata. A graded association was observed over the Hcy strata, indicating a dose-response association, with the most apparent effect when Hcy levels exceeded approximately 15 µmol/L. No studies explored a potential nonlinear association between Hcy levels and ischemic stroke. Six studies were included in a meta-analysis, showing an OR of 1.43 (95% confidence interval [CI]: 1.28–1.61) per 5 µmol/L increase in Hcy levels. Conclusion This review and meta-analysis indicate a dose-response association between Hcy levels and ischemic stroke. An evident increase in effect measures was observed when Hcy levels exceeded 15 µmol/L, indicating a nonlinear association between ischemic stroke and Hcy levels. This nonlinear association warrants further study.This study is registered with clinical trial ( https://www.crd.york.ac.uk/prospero/ ; unique identifier: CRD42019130371).

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Section: Resultsmentioning

confidence: 99%

Hyperhomocysteinemia and Ischemic Stroke: A Potential Dose-Response Association—A Systematic Review and Meta-analysis

Holmen

Hvas

Arendt

2021

TH Open

View full text Add to dashboard Cite

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“…On the other hand, Kara et al [9] have found no significant difference in serum vitamin B-12, folate and homocysteine levels between the patients with ischemic stroke and control groups. Urinary MMA concentrations and erythrocyte folate levels were significantly higher in patients compared to controls.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, mass spectrometric detection was performed. Kara et al [9] analyzed this parameter with flourometric detection. The number of the participants in our study was also higher compared to Kara et al [9].…”

Section: Discussionmentioning

confidence: 99%

“…Urinary methylmalonic acid levels were found to be associated with ischemic stroke [9]. Low serum High density lipoprotein cholesterol (HDL-cholesterol) and triglyceride levels have been concluded to be related with post-acute ischemic stroke mortality [14].…”

Section: Introductionmentioning

confidence: 99%

“…Increased methylmalonic acid levels in the urine were found to be associated with ischemic stroke [9]. Homocysteine is considered to play a role in the pathogenesis of ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

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