Urinary microRNA in Diabetic Kidney Disease: A Literature Review

Abstract

Diabetic kidney disease is the most common primary disease of end-stage kidney disease globally; however, a sensitive and accurate biomarker to predict this disease remains awaited. microRNAs are endogenous single-stranded noncoding RNAs that have intervened in different post-transcriptional regulations of various cellular biological functions. Previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of Transforming Growth Factor-β1-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. In this review, we describe the available experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and discuss the future application of microRNA in routine practice.

Liquid Biopsy: A New Avenue for the Diagnosis of Kidney Disease: Diabetic Kidney Disease, Renal Cancer, and IgA Nephropathy

“…Urinary exosomes offer a comprehensive perspective on the entire urinary system [17]. Previous studies have indicated its potential involvement in the pathogenesis of diabetic nephropathy, including the control of fibrosis through transforming growth factor β1, the extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor regulation, cytokine production, and activation of the redox system [18].…”

Diabetes, Hypertension and Cardiovascular Disease: Clinical Insights, Mechanisms and Pharmacotherapies

“…MicroRNA is found to play important roles in the pathophysiology of diabetic kidney disease. Lee et al [13] examine the potential applications of urinary microRNA on diabetic kidney disease from the emerging experimental and clinical evidence. While the results of using urinary microRNA as a non-invasive disease marker to predict diabetic kidney disease appear promising, further experimental standardization and clinical verification trials are warranted to promote its application practically.…”

Integration of omics technologies for the identification of predictive biomarkers in type 2 diabetes: a comprehensive analysis of recent literature

“…(Padilla-Martínez et al, 2021) microRNA Prognostic hsa-miR-126, hsa-miR-29a, hsa-miR-133b, hsa-miR-342, hsa-miR-30a, and others(Lee et al, 2023) …”