Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance

Satake, Eiichiro; Matsushita, Rie; Kitsuda, Kazuteru; Ohtaka, Kohnosuke; Nagata, Eiko; Yamaguchi, Rie Shigetomi; Sano, Saburo; Fujisawa, Yasuko; Nakanishi, Toshiki; Nakagawa, Yuichi; Ohzeki, Takehiko

doi:10.1515/jpem-2015-0107

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…In contrast, the DUMI test requires no blood collection, but involves the loading of 75 g of glucose, resulting in a burden on the examinees. In this regard, Takakado et al reported that UMI levels from urine samples selfcollected at home were closely associated with blood glucose parameters obtained from a 75-g OGTT test meal loading at home, focusing on the high stability of MI in urine at room temperature 15 . Although further study is necessary, the UMI test can be carried out with urine and, therefore, performed at home using test meals on a separate day from the date of a health checkup.…”

Section: Discussionmentioning

confidence: 99%

“…Urinary MI (UMI) is known to increase with a decrease in glucose tolerance in the order of healthy individuals, prediabetes, IGT and diabetes, and it is known that the determination of ΔUMI, the difference between UMI before glucose loading and UMI 120 min after glucose loading during the 75‐g OGTT, is useful for identifying patients at high risk of diabetes 12 , 13 , 14 , 15 . We studied the participants with FPG levels of 100–125 mg/dL, and developed the cut‐off value of 10 mg/g Cre to detect glucose intolerance with the sensitivity of 93% for diabetes and 68% for IGT 16 .…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of individuals who developed type 2 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo‐inositol as a risk factor for developing diabetes

Yamagata,

Ogata,

Koda

et al. 2023

J of Diabetes Invest

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Aims/IntroductionThe aim of this study was to clarify the characteristics of individuals with prediabetes who developed type 2 diabetes despite undergoing interventions, and to evaluate the performance of urinary myo‐inositol (UMI) as a noninvasive indicator for the risk of developing diabetes.Materials and MethodsA total of 51 individuals with prediabetes who underwent a 75‐g oral glucose tolerance test, ΔUMI (the difference in the UMI : creatinine ratio between before and 120 min after 75‐g glucose loading), fasting plasma glucose, insulin, hemoglobin A1c, noninvasive testing (age, body mass index, blood pressure) and general blood tests were measured at baseline, and underwent dietary/exercise guidance for 8 years were studied.ResultsA total of 31 participants developed diabetes in 8 years. At baseline, the group that developed diabetes was characterized by high ΔUMI, hemoglobin A1c, fasting plasma glucose and low high‐density lipoprotein cholesterol, and insulinogenic index (I.I.). I.I and ΔUMI showed a higher correlation than fasting plasma glucose and hemoglobin A1c. Regarding diabetes onset within 8 years, Cox regression analysis of diabetes onset showed the baseline ΔUMI is an independent predictor, adjusted for the result of not only noninvasive markers, but also that of noninvasive and general blood markers. The log‐rank test showed that all glycemic indicators were significantly associated with diabetes onset.ConclusionParticipants who developed type 2 diabetes from prediabetes despite undergoing interventions were characterized by high glycemic control markers and low I.I. As noninvasive measurement of ΔUMI is associated with I.I. and diabetes onset, it could be a useful indicator for identifying individuals with a high risk of diabetes onset.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characteristics of individuals who developed type 2 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo‐inositol as a risk factor for developing diabetes

Yamagata,

Ogata,

Koda

et al. 2023

J of Diabetes Invest

View full text Add to dashboard Cite

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Imbalance of Myoinositol and D‐Chiro‐Inositol in Saliva of Children With Type‐1 Diabetes Mellitus: A Cross‐Sectional Study

Lima,

Alves Cabral,

Costa E Forti

et al. 2024

Clinical Endocrinology

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ObjectiveEarlier work suggests Myoinositol (MI) and D‐chiro‐ inositol (DCI) imbalance in urine and plasma of diabetic patients, and their potential for monitoring insulin resistance. This study aimed to assess levels of Myoinositol (MI) and D‐chiro‐ inositol (DCI) in saliva of children with type 1 diabetes mellitus (DM‐1) and controls, to verify if concentrations of MI and DCI are similarly altered in saliva, exploring their potential for monitoring DM‐1.Design, Patients and MeasurementsThis cross‐sectional clinical study enroled 45 patients (DM‐1, n = 25; Controls, n = 20). Children aged 3–12 years with fasting blood glucose levels > 126 mg/dL, and HbA1c levels > 7%. Saliva was collected, and salivary measurements included pH, flow rates and concentrations of MI, DCI and glucose, employing high‐performance liquid chromatography. Periodontal health was assessed using bleeding and plaque indices.ResultsChildren with DM‐1 showed elevated MI (p = 0.001), reduced DCI (p = 0.001), and increased MI‐DCI ratio (p = 0.001). The MI‐DCI ratio was elevated by 16‐fold among diabetic children. Plaque (p = 0.003) and gingival bleeding (p = 0.001) were higher in DM‐1 than controls. The MI increased the odds of an outcome of DM‐1 by 174%, while DCI reduced the odds by 63%, highlighting their strong and opposing effects on DM‐1.ConclusionsChildren with DM‐1 express higher MI and lower DCI levels, while non‐diabetic children show an inversion of these concentrations. Inositol imbalance in saliva of diabetic children resembles previous results in urine, and represents a possible venue for monitoring this disease, paving the way for future investigations into salivary inositols.

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Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance

Abstract: These studies demonstrated the normal range of UMI in children and possibility of a novel biomarker for early detection of glucose intolerance in children.

Cited by 2 publications

References 25 publications

Characteristics of individuals who developed type 2 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo‐inositol as a risk factor for developing diabetes

Characteristics of individuals who developed type 2 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo‐inositol as a risk factor for developing diabetes

Imbalance of Myoinositol and D‐Chiro‐Inositol in Saliva of Children With Type‐1 Diabetes Mellitus: A Cross‐Sectional Study

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