Urinary Nephrin as a Marker of Glomerular Diseases in Pediatric Patients.

El-Sebai, Aziza; Yousef, Mervat; Shaaban, Menat Allah; Farsy, Mohamed El

doi:10.21608/geget.2021.216778

GEGET

2021

DOI: 10.21608/geget.2021.216778

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Urinary Nephrin as a Marker of Glomerular Diseases in Pediatric Patients.

Aziza El-Sebai

Mervat Yousef

Menat Allah Shaaban

et al.

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2024

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Cited by 1 publication

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Human and Mouse Nephrin and Their Interactions With 13 Proteins: An In Silico Study

Narayanaswamy,

Harika,

Prabhakaran

2024

Cureus

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BackgroundHuman nephrin (hNeph) (podocyte protein) has been known to be involved in both the formation and maintenance of the slit diaphragm (SD) and also acts as a hub protein in the podocyte by modulating cell polarity, cell survival, cell adhesion, cytoskeletal organization, mechano-sensing, and SD turn-over. MethodologyIn the present investigation, we aimed to analyse the hNeph and mouse nephrin (mNeph) and their interactions with 13 proteins using the molecular docking method. The 13 selected human proteins which include matrix metalloproteinases (MMP 2 and 9), retinol-binding proteins (RBP 3 and 4), kallikrein 1 (KLK 1), uromodulin, insulin-like growth factor binding protein 7 (IGFBP7), cystatin C, podocin, beta arrestin 1, vang-like protein 2 (VANGL2), dynamin 1, and tensin-like C1 domain-containing phosphatase (TENC1) were studied on the docking analysis of hNeph and mNeph by using the HDOCK (protein-protein) docking method. In addition, the physicochemical (PC) properties of 15 proteins were performed using the ProtParam web server. ResultsIn the present investigation, five chosen human proteins, namely, IGFBP7, cystatin C, podocin, VANGL2, and TENC1, have exhibited theoretical isoelectric point (PI) values greater than 7.0. The protein-protein docking analysis has shown that hKLK and hVANGL2 exhibited the maximum docking score of -206.39 kcal/mol and -329.28 (kcal/mol) with the target proteins mNeph and hNeph, respectively. ConclusionsThus, the current finding highlights the interactions of hNeph and mNeph with 13 chosen proteins, which may help in renal disease management.

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Human and Mouse Nephrin and Their Interactions With 13 Proteins: An In Silico Study

Narayanaswamy,

Harika,

Prabhakaran

2024

Cureus

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Urinary Nephrin as a Marker of Glomerular Diseases in Pediatric Patients.

Cited by 1 publication

References 11 publications

Human and Mouse Nephrin and Their Interactions With 13 Proteins: An In Silico Study

Human and Mouse Nephrin and Their Interactions With 13 Proteins: An In Silico Study

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