Urinary neutrophil gelatinase-associated lipocalin is a biomarker of delayed graft function after kidney transplantation

Capelli, Irene; Baraldi, Olga; Comai, Giorgia; Sala, Elisa; Cappuccilli, Maria; Donadei, Chiara; Cuna, Vania; Angelini, Maria Laura; Donati, Gabriele; Manna, Gaetano La

doi:10.2147/trrm.s122090

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Thus, the main potential advantage arising from this finding is the possibility to identify and stratify patients according to their risk of dialysis need after transplant, prior to the diagnosis of DGF. Most of the studies, including one from our group, concur to suggest that patients with higher uNGAL values in the early posttransplant phases are more prone to develop DGF and tend to maintain increased uNGAL levels, or even experience a further rise in the following days, different from patients with prompt function (25,34,37,38). However, contrasting results by Hollmen et al (39), even if the higher initial uNGAL levels in DGF patients is confirmed, it showed a rapid decline on the following day, similar to transplant recipients with immediate recovery of graft function.…”

Section: Urinary Ngal and Dgfsupporting

confidence: 56%

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

et al. 2017

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Neutrophil gelatinase‐associated lipocalin (NGAL), a protein belonging to the lipocalin superfamily initially found in activated neutrophils, is expressed by several cell types, including kidney tubule. The increase in NGAL production and release from tubular cells in response to various insults has been proven to predict acute kidney injury (AKI). For this reason, it has emerged as a valuable noninvasive biomarker of AKI in clinical nephrology. Also in the renal transplant setting, different studies have indicated NGAL as a valuable tool, especially in the early postoperative period, since the currently available clinical and laboratory parameters remain poorly sensitive to monitor immediate posttransplant graft function. This is an analysis of the recent literature to assess the utility of plasma and urinary NGAL, exosomal mRNA for NGAL, and NGAL levels in the perfusate of machine‐perfused kidneys for the prediction of graft function recovery in the early postsurgery phase after renal transplantation. We found that NGAL appears as a promising troponin‐like biomarker to detect short‐term impairment of graft function after renal transplant, but there are still some limitations in its clinical application, essentially related to its low specificity. Moreover, comparing NGAL assayed in serum, urine, machine‐perfusate, or as exosomal mRNA, each one has shown limitations and benefits in terms of predictive performance for DGF, according to various existing studies, feasibly due to different cut‐off levels, designs and patient sample sizes.

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Section: Urinary Ngal and Dgfsupporting

confidence: 56%

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

et al. 2017

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“…In addition, they showed that falling levels of this protein on day 3 after surgery were a good predictor of renal function one month after transplantation. Capelli et al [ 22 ], based on retrospectively evaluating the clinical and laboratory data of 72 patients after renal transplantation, concluded that uNGAL combined with other markers could be more helpful in the early evaluation of renal function in the first week following kidney transplantation. Additionally, Lacquaniti et al [ 23 ] found that both urinary and serum NGAL levels provide reliable information for predicting kidney injury.…”

Section: Biomarkers Of Allogeneic Kidney Transplant Rejectionmentioning

confidence: 99%

The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

Rogulska

Wojciechowska‐Koszko

Dołęgowska

et al. 2022

Journal of Immunology Research

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Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has become standard clinical practice, and it has a significant impact on reducing mortality and improving the quality of life of patients. Allogenic transplantation induces an immune response, which may lead to the rejection of the transplanted organ. The gold standard for evaluating rejection of the transplanted kidney by the recipient’s organism is a biopsy of this organ. However, due to the high invasiveness of this procedure, alternative diagnostic methods are being sought. Therefore, the biomarkers may play an essential predictive role in transplant rejection. A review of the most promising biomarkers for early diagnosis and prognosis prediction of allogenic kidney transplant rejection summarizes novel data on neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), C-X-C motif chemokine 10 (CXCL-10), cystatin C (CysC), osteopontin (OPN), and clusterin (CLU) and analyses the dynamics of changes of the biomarkers mentioned above in kidney diseases and the mechanism of rejection of the transplanted kidney.

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Biomarkers as diagnostic tests for delayed graft function in kidney transplantation

Lai

Yee

Ying

et al. 2021

Transplant International

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Delayed graft function (DGF) after kidney transplantation is associated with inferior outcomes and higher healthcare costs. DGF is currently defined as the requirement for dialysis within seven days post-transplant; however, this definition is subjective and nonspecific. Novel biomarkers have potential to improve objectivity and enable earlier diagnosis of DGF. We reviewed the literature to describe the range of novel biomarkers previously studied to predict DGF. We identified marked heterogeneity and low reporting quality of published studies. Among the novel biomarkers, serum NGAL had the greatest potential as a biomarker to predict DGF, but requires further assessment and validation through larger scale studies of diagnostic test performance. Given inadequacies in the dialysis-based definition, coupled with the high incidence and impact of DGF, such studies should be pursued.

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Urinary neutrophil gelatinase-associated lipocalin is a biomarker of delayed graft function after kidney transplantation

Cited by 3 publications

References 20 publications

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

Biomarkers as diagnostic tests for delayed graft function in kidney transplantation

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