Urinary Neutrophil Gelatinase-Associated Lipocalin Levels in Neonates

Chen, Chi-Nien; Chou, Chia-Hung; Jeng, Suh‐Fang; Tsai, I-Jung; Chen, Pau‐Chung; Chen, Chien-Yi; Chou, Hung-Chieh; Tsao, Po‐Nien; Hsieh, Wu‐Shiun

doi:10.1016/j.pedneo.2015.09.003

Cited by 15 publications

(13 citation statements)

References 27 publications

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“…These results are consistent with the literature data [26, 27]. Whether this is due to differences in tubular function or reflects glomerular filtration or other interfering factors remains a matter for speculation.…”

Section: Discussionsupporting

confidence: 93%

The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction

et al. 2018

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Background: Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease. Objectives: The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1). Methods: The study included 126 term neonates. Thirty-eight newborns were the result of pregnancies complicated by IUGR. Eighty-eight healthy newborns were the result of normal pregnancies with no prenatal or perinatal complications. The concentrations of urinary NGAL and KIM-1 were determined with a commercially available ELISA kit and were normalized for urinary creatinine (Cr) concentration. Results: We found a significantly higher urinary concentration of NGAL and NGAL/Cr ratio in newborns from pregnancies complicated by IUGR when compared to the reference group. We found that female gender was associated with a higher concentration of urinary NGAL and also urinary NGAL/Cr. Conclusions: This is the first work that demonstrates that urinary NGAL concentration and urinary NGAL/Cr are significantly higher in infants that are small for gestational age than in appropriate-for-gestational-age infants. This might indicate subclinical kidney damage in newborns with IUGR.

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Section: Discussionsupporting

confidence: 93%

The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction

et al. 2018

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“…In our study, we found significantly higher excretion of NGAL in girls than in boys, both for urine NGAL levels and urine NGAL/creatinine. Being female was also independently associated with higher values of urine NGAL/creatinine in the studies by Askenazi et al and Chen et al . Huynh et al demonstrated that urine NGAL concentrations in girls were 79% higher than in boys , and this gender difference has also been described in a healthy child and adult population .…”

Section: Table Of Demographics and Results According To Gendermentioning

confidence: 82%

“…However, no data from healthy neonates were obtained. A study by Chen et al reported that the median value of urine NGAL in third day of life in term infants was 88.1 ng/mL . Even higher urine NGAL levels on first day of life was published by DeFreitas et al, but the study only comprised 13 neonates .…”

Section: Table Of Demographics and Results According To Gendermentioning

confidence: 96%

Health term‐born girls had higher levels of urine neutrophil gelatinase‐associated lipocalin than boys during the first postnatal days

et al. 2016

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“…SCr was measured once in four of 113 (3.5%), twice in six of 113 (5.3%), three times in ten of 113 (8.8%), and at least four times in 93 of 113 (82%) of the cohort during the 2 weeks of life (median, 5 [range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14] days). Neonatal AKI was defined using the Kidney Disease Improving Global Outcomes AKI definition, in which stage 1 was defined as an increase of SCr $ 0.3 mg/dl or Figure 1.…”

Section: Definition Of Outcomesmentioning

confidence: 99%

“…Prior literature has shown that in premature infants without AKI, urine proteins will be highest among those with the lowest GA, probably because of the passive loss of proteins in the context of immature tubular function (6)(7)(8). Previously, we (7) and others (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) have published data on the ability of urine biomarkers to predict AKI in neonates; however, these studies are limited by the size of the cohort or the use of nested case-control methods, with most of these studies evaluating only one biomarker. In addition, previous studies were subject to risk of misclassification bias, given that many infants had only a few SCr levels measured to determine AKI.…”

Section: Introductionmentioning

confidence: 99%

Acute Kidney Injury Urine Biomarkers in Very Low-Birth-Weight Infants

Askenazi

Koralkar

Patil

et al. 2016

CJASN

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Background and objectives Serum creatinine (SCr)-based AKI definitions have important limitations, particularly in very low-birth-weight (VLBW) neonates. Urine biomarkers may improve our ability to detect kidney damage. We assessed the association between 14 different urine biomarkers and AKI in VLBW infants.Design, setting, participants, & measurements We performed a prospective cohort study on 113 VLBW infants (weight #1200 g or ,31 weeks' gestation) admitted to a regional neonatal intensive care unit at the University of Alabama at Birmingham between February 2012 and June 2013. SCr was measured on postnatal days 1, 2, 3, and 4 and was combined with clinically measured SCr to determine AKI according to Kidney Disease Improving Global Outcomes AKI definition (increase in SCr $0.3 mg/dl or $50% increase from previous lowest value). Urine was collected on the first 4 days (average number of urine collections, 3; range, 1-4). The maximum urine biomarkers and urine biomarker/creatinine levels were calculated for 12 urine biomarkers, and the minimum urine biomarker and biomarker/creatinine levels were assessed for two urine biomarkers. We compared these values between infants with and those without AKI. Ideal cutoffs, area under the receiver-operating characteristic curve , and area under the curve adjusted for gestational age were calculated.Results Cumulative incidence of AKI during the first 2 postnatal weeks was 28 of 113 (25%). Infants with AKI had higher maximum levels of urine cystatin C, neutrophil gelatinase-associated lipocalin, osteopontin, clusterin, and a glutathione S-transferase (2.0, 1.8, 1.7, 1.7, and 3.7 times higher, respectively) than infants without AKI. In addition, infants with AKI had lower minimum levels of epithelial growth factor and uromodulin than those without AKI (1.4 and 1.6 times lower, respectively). Most but not all participants had their maximum (or minimum) biomarker values preceding AKI. These associations remained after adjustment for gestational age.Conclusions Urine biomarkers measured in the first 4 days of life are associated with AKI during the first postnatal weeks. Further evaluations are necessary to determine whether these biomarkers can predict important clinical outcomes. In addition, intervention studies that use biomarkers to stratify enrollment groups are needed before bedside evaluations can be incorporated into care.

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Urinary Neutrophil Gelatinase-Associated Lipocalin Levels in Neonates

Abstract: This study presents preliminary data on uNGAL levels in neonates in Taiwan. A large-scale study investigating the correlations between uNGAL and with gestational age, birth body weight, sex, and PNA is recommended.

Cited by 15 publications

References 27 publications

The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction

The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction

Health term‐born girls had higher levels of urine neutrophil gelatinase‐associated lipocalin than boys during the first postnatal days

Acute Kidney Injury Urine Biomarkers in Very Low-Birth-Weight Infants

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