Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients

Bolignano, Davide; Coppolino, Giuseppe; Campo, Susanna; Aloisi, Carmela; Nicocia, Giacomo; Frisina, N; Buemi, Michele

doi:10.1093/ndt/gfm541

Cited by 123 publications

(102 citation statements)

References 15 publications

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“…Interestingly, apart from the already cited predictive value, a strict, independent, and inverse correlation with estimated GFR was described for both sNGAL and uNGAL, suggesting that under these particular conditions this protein may also represent a surrogate index of residual renal function, similar to what has previously been described elsewhere (27)(28)(29).…”

Section: Discussionsupporting

confidence: 72%

Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease

Bolignano

Lacquaniti²,

Coppolino³

et al. 2009

Clinical Journal of the American Society of Nephrology

485

356

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Background and objectives: Chronic kidney disease (CKD) has recently assumed epidemic proportion, becoming a troubling emerging cause of morbidity, especially if it progresses to terminal stage (ESRD). The authors aimed to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL), a novel specific biomarker of acute kidney injury, could predict the progression of CKD.Design, setting, participants, & measurements: Serum and urinary NGAL levels, together with a series of putative progression factors, were evaluated in a cohort of 96 patients (mean age: 57 ؎ 16 years) affected by nonterminal CKD (eGFR >15 ml/min/1.73 m 2 ) of various etiology. Progression of CKD, assessed as doubling of baseline serum creatinine and/or onset of ESRD, was evaluated during follow-up.Results: At baseline, both serum and urinary NGAL were inversely, independently, and closely related to eGFR. After a median follow-up of 18.5 mo (range 1.01 to 20), 31 patients (32%) reached the composite endpoint. At baseline, these patients were significantly older and showed increased serum creatinine, calcium-phosphate product, C-reactive protein, fibrinogen, daily proteinuria, and NGAL levels, whereas eGFR values were significantly lower. Univariate followed by multivariate Cox proportional hazard regression analysis showed that urinary NGAL and sNGAL predicted CKD progression independently of other potential confounders, including eGFR and age.Conclusion: In patients with CKD, NGAL closely reflects the entity of renal impairment and represents a strong and independent risk marker for progression of CKD.

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Section: Discussionsupporting

confidence: 72%

Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease

Bolignano

Lacquaniti²,

Coppolino³

et al. 2009

Clinical Journal of the American Society of Nephrology

485

356

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“…Furthermore, we found that tubulointerstitial NGAL expression significantly correlated with proteinuria, GFR and CI. The result agrees with the report of Bolignano et al, who also showed that urinary NGAL concentrations correlated with renal function and proteinuria [19]. In addition, we found that the tubulointerstitial expression of NGAL is related to treatment response.…”

Section: Discussionsupporting

confidence: 93%

The gene expression of NGAL and TLR9 in glomerulus and tubulo-interstitium of patients with lupus nephritis

Lü¹,

Kwan²,

Lai³

et al. 2011

ABB

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“…NGAL is a ubiquitous lipocalin iron-carrying protein, which is heavily expressed in renal tubular cells and can be detected in the urine after ischemic kidney injury. Data from small observational studies, many cross-sectional, have suggested an association between the level of urinary NGAL and magnitude of kidney injury (14)(15)(16). CRIC Study investigators examined the association between baseline urinary NGAL levels and a composite outcome of ESRD or halving of eGFR.…”

Section: Measurement Of Kidney Functionmentioning

confidence: 99%

Chronic Renal Insufficiency Cohort Study (CRIC)

Denker¹,

Boyle²,

Anderson³

et al. 2015

Clinical Journal of the American Society of Nephrology

108

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The Chronic Renal Insufficiency Cohort (CRIC) Study is a United States multicenter, prospective study of racially and ethnically diverse patients with CKD. Although the original aims of the study were to identify novel predictors of CKD progression and to elucidate the risk and manifestations of cardiovascular disease among nearly 4000 individuals with CKD, the CRIC Study has evolved into a national resource for investigation of a broad spectrum of CKD-related topics. The study has produced >90 published scientific articles, promoted many young investigative careers in nephrology, and fostered international collaborations focused on understanding the global burden of CKD. The third phase of the CRIC Study will complete enrollment of 1500 additional study participants in 2015 and is designed to answer questions regarding morbidity and mortality in mild-to-moderate CKD and to assess the burden of CKD in older persons. This review highlights some of the salient findings of the CRIC Study in the areas of race and ethnicity, CKD progression, CKD and cognition, and cardiovascular disease outcomes; it also outlines the ongoing and forthcoming opportunities for the global nephrology community to enhance its understanding of CKD and related complications through the study.

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Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients

Cited by 123 publications

References 15 publications

Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease

Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease

The gene expression of NGAL and TLR9 in glomerulus and tubulo-interstitium of patients with lupus nephritis

Chronic Renal Insufficiency Cohort Study (CRIC)

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