Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections

Barreto, Rogelio; Elia, Chiara; Solà, Elsa; Moreira, Rebeca; Ariza, Xavier; Rodríguez, Ezequiel; Graupera, Isabel; Alfaro, Ignacio; Morales-Ruíz, Manuel; Poch, Estaban; Guevara, Mónica; Fernández, Javier; Jiménez, Wladimiro; Arroyo, Vicente; Ginès, Pere

doi:10.1016/j.jhep.2014.02.023

Cited by 100 publications

(99 citation statements)

References 19 publications

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“…In our study the mean±SD of uNGAL was significantly greater in patients who died compared to those who survived until discharge. This was supported by other studies which found that uNGAL was a good predictor of mortality in different settings [23,26,44] .…”

Section: Discussionsupporting

confidence: 82%

“…Few studies reported the role of uNGAL in prediction of mortality. Of them, Verna et al reported that uNGAL was an independent predictor of inpatient mortality in patients with liver cirrhosis [26] , Baretto et al showed that uNGAL was an independent 3-month mortality predictor in cirrhotic patients with AKI and bacterial infection [44] . However, Treeprasertsuk et al reported that uNGAL was an independent predictor of 30-day mortality [25] .…”

Section: Discussionmentioning

confidence: 99%

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Urinary Neutrophil Gelatinase Associated Lipocalin as a Biomarker for Diagnosis and Prognosis of Acute Kidney Injury (AKI) in Cirrhotic Patients

Elzohri¹

2017

jmscr

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Urinary Neutrophil Gelatinase Associated Lipocalin as a Biomarker for Diagnosis and Prognosis of Acute Kidney Injury (AKI) in Cirrhotic Patients

Elzohri¹

2017

jmscr

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“…Human studies suggest that NGAL measurements either in urine and serum may differentiate acute tubular necrosis from type 1 HRS, pre-renal azotemia or chronic kidney disease [11]. Two recent studies suggest that elevated urinary NGAL is predictive of early mortality in cirrhotic patients with AKI [12,13]. However, NGAL lacks specificity as it is also elevated in other acute and chronic inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

Kidney Biomarkers in Hepatorenal Syndrome

Freeman¹

2017

GHOA

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Cirrhosis is the result of advanced liver disease characterized by fibrosis due to increased portal hypertension. Patients with cirrhosis are prone to develop acute kidney injury (AKI) triggered by bacterial infections, hypovolemia, nephrotoxic drugs and intrinsic kidney disease. The diagnostic criteria for the diagnosis of HRS continue to rely on serum creatinine levels which should be interpreted with caution in patients with cirrhosis. To date, accurate biomarkers indicative of renal function are lacking. Further validation with prospective studies is warranted to evaluate the value of novel biomarkers.

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“…21 In fact, proteomic biomarkers constitute a potential armamentarium for enhancing the management of patients with renal diseases by enabling a more accurate and earlier detection. 22 Several novel biomarkers have recently been documented as diagnostic and prognostic tools in diseases such as pediatric acute kidney injury, [23][24][25][26][27][28][29][30][31][32][33][34][35][36] and urinary tract infection. [37][38][39][40][41][42][43] Similarly, the utility of biomarkers in childhood idiopathic nephrotic syndrome has been reported; [12][13][14][15][16][17][18][19][20] their application constitutes a noninvasive approach in diagnostic nephrology, as they can be used as diagnostic and prognostic tools in idiopathic nephrotic syndrome, as well as discriminatory tools in distinguishing SRNS from SSNS (Table 1).…”

Section: The Diagnostic Prognostic and Discriminatory Roles Of Biommentioning

confidence: 99%

The role of novel biomarkers in childhood idiopathic nephrotic syndrome: a narrative review of published evidence

Uwaezuoke

2017

IJNRD

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Two histological subtypes of idiopathic nephrotic syndrome are commonly recognized in children, namely minimal change nephropathy and focal segmental glomerulosclerosis. Children with minimal change nephropathy (the majority of whom are steroid-sensitive) and focal segmental glomerulosclerosis (the majority of whom are steroid-resistant) require early identification in order to ensure appropriate therapeutic intervention and better outcome. Although renal biopsy and histology remain the ideal diagnostic steps to identify these histological subtypes, reports indicate that serum and urinary biomarkers are now being utilized in the investigation of childhood idiopathic nephrotic syndrome. This paper aims to review the diagnostic and prognostic utility of novel biomarkers in childhood idiopathic nephrotic syndrome and to highlight their role in differentiating steroid-sensitive nephrotic syndrome (SRNS) from steroid-resistant nephrotic syndrome (SSNS). Using the terms "idiopathic nephrotic syndrome," "children," and "biomarkers" the PubMed database was searched for relevant studies related to the topic. Biomarkers such as adiponectin, neopterin, β2-microglobulin, and N-acetyl-β-D glucosaminidase were reported as diagnostic markers. In addition to neopterin and N-acetyl-β-D glucosaminidase, urine vitamin D-binding protein and α1β-glycoprotein were shown to differentiate SRNS from SSNS while N-acetyl-β-D glucosaminidase and β2-microglobulin could predict steroid responsiveness and renal outcome in SRNS. Although progress has been made in demonstrating the diagnostic and prognostic utility of these biomarkers, their limited availability in most laboratories has precluded a complete paradigm shift from the conventional renal biopsy. Nevertheless, further longitudinal studies are required to establish their usefulness as noninvasive predictors of disease response to immunosuppressive therapy.

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Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections

Cited by 100 publications

References 19 publications

Urinary Neutrophil Gelatinase Associated Lipocalin as a Biomarker for Diagnosis and Prognosis of Acute Kidney Injury (AKI) in Cirrhotic Patients

Urinary Neutrophil Gelatinase Associated Lipocalin as a Biomarker for Diagnosis and Prognosis of Acute Kidney Injury (AKI) in Cirrhotic Patients

Kidney Biomarkers in Hepatorenal Syndrome

The role of novel biomarkers in childhood idiopathic nephrotic syndrome: a narrative review of published evidence

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