Urinary normetadrenaline excretion in essential hypertension

Stott, A.W.; Robinson, R.

doi:10.1016/0009-8981(67)90188-x

Cited by 16 publications

(4 citation statements)

References 8 publications

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“…Support for relating the findings in the rat to the clinical situation is offered, however, by the work of Gitlow et al (9) who reported a slightly increased rate of disappearance from plasma of exogenously administered DL-norepinephrine-8H and interpreted this as possibly representing a defect in tissue-binding mechanisms. Also, favoring this hypothesis are recent reports of a statistically significant increase in the urinary excretion of norepinephrine (6) and normetanephrine (5) in hypertensive as compared with control subjects.…”

Section: Effects Of Antiadrenergic Drugsmentioning

confidence: 98%

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Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs

DeQuattro¹,

Sjoerdsma²

1968

J. Clin. Invest.

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A B S T R A C T Intravenous administration of tritium-labeled 3,4-dihydroxyphenylalanine (dopa) to human subjects resulted in the labeling of endogenous catecholamines and vanillylmandelic acid (VMA). Determination of the changes in specific activity of these compounds with time in fractional collections of urine and in cardiac biopsies from patients undergoing corrective cardiac surgery permitted estimation of apparent turnover rates. The average half-time of the exponential decline in specific activity of labeled urinary norepinephrine was about 8 hr and that of VMA was 11-16 hr in five normal subjects. No significant differences from normal were observed in eight patients with essential hypertension. The average half-life of norepinephrine was only 5 hr in cardiac patients undergoing surgery, and the levels and rate of decline of cardiac norepinephrine specific activity correlated well with the exponential phase of the urinary disappearance curve. There were significant effects of treatment with alpha-methyltyrosine, reserpine, and pargyline hydrochloride on the labeling and apparent turnover rates of norepinephrine and VMA; the effects noted were consistent with known actions of these three drugs. It is suggested that the technique used is a suitable means of assessing "over-all" catecholamine metabolism in man, particulary if combined with

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Section: Effects Of Antiadrenergic Drugsmentioning

confidence: 98%

“…3) of urinary catecholamine metabolites have failed to reveal any consistent abnormalities in cases of essential hypertension. Nonetheless, a few reports of alterations in the metabolism of endogenous or exogenous norepinephrine in human (3)(4)(5)(6) and experimental (7,8) hypertension indicate the issue is not yet settled.…”

Section: Introductionmentioning

confidence: 99%

Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs

DeQuattro¹,

Sjoerdsma²

1968

J. Clin. Invest.

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“…3 Professor of Medicine. 295 (Von Euler et alii, 1954;Weil-Mahlerbe and Bone, 1957;Von Studnitz, 1960;Stott and Robinson, 1967), this has not been the experience of other workers (Crout et alii, 1961;Brunjes, 1964;Wolf et alii, 1965).…”

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confidence: 94%

The Excretion of Free Noradrenaline and Adrenaline by Healthy Young Subjects and by Patients With Essential Hypertension

Nestel

Doyle

1968

Australasian Annals of Medicine

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SUMMARY The possible relationship between arterial pressure and the excretion of free noradrenaline and adrenaline in the urine was the subject of a study of 58 university students and 33 patients with untreated essential hypertension. The urine was collected during the morning with the subjects fasting, recumbent and undisturbed. The mean excretion rate of free noradrenaline by the students was 0.94 µg. per hour and by the hypertensives, 1.65 µg. per hour. The mean excretion rates of free adrenaline were 0.47 and 0.73 µg. per hour respectively. Although the difference in catecholamine excretion rates between the two groups was highly significant (P = < 0.01), there was a considerable overlap. There was a significant correlation with the student group between the excretion of both free noradrenaline and adrenaline and the systolic blood pressure, demonstrating that, in normal subjects, casual blood pressure at rest is partly although not very closely related to catecholamine production. Although catecholamine excretion rates were higher in the hypertensive group, a significant correlation with blood pressure was not found.

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“…21 These conflicting results may be due to different conditions at the examination of subjects. In the present study which was performed under different conditions, it was clarified that 1) in sleep there were no differences in the urinary excretion of E, NE, MN, NMN and VMA between the hypertensive and normotensive subjects, 2) at walking, the urinary excretion of E, NE, MN, NMN and VMA was 3 to 6 times higher than that in sleep in both groups, and 3) the rate of increase of catecholamines in the hypertensive subjects at walking was higher than that in the normotensive subjects; especially there was a significant difference in the urinary excretion of VMA at walking between the hypertensive and normotensive subjects.…”

Section: Discussionmentioning

confidence: 99%

Urinary Excretion of Catecholamine Derivatives in Essential Hypertension

Inoue

Takahashi

Adachi

et al. 1968

Tohoku J. Exp. Med.

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Urinary excretion of norepinephrine (NE), epinephrine (E), normetanephrine (NMN), metanephrine (MN) and vanillyl mandelic acid (VMA) were measured in 10 hypertensive and 10 normotensive subjects at walking and in sleep. No difference in urinary excretion of each of NE, E, NMN, MN and VMA was observed in sleep between the hypertensive and normotensive subjects. Urinary excretions of NE, E, NMN, MN and VMA at walking were 3 to 6 times higher than those in sleep in both groups. The rate of increase in catecholamine excretion at walking was higher in the hypertensive subjects. At walking, urinary excretion of VMA in the hypertensive group was significantly higher. The ratio of VMA to total catecholamine was lower at walking.Elevated urinary catecholamine excretion in the hypertensive suggests that the substance plays a role as a causative factor of hypertension.Studies of hypertension induced by endogenous substances have been carried out with special attention to the adrenal medulla. However, the results of urinary excretion of catecholamines and their metabolites in essential hypertension have been controversial.It is well established that excretion of catecholamines is increased under various conditions such as upright posture,1 exercise2 and emotional tension.3 Consequently, a proper comparison is possible only when the effects of such conditions are minimized at the measurement.The present study was made to determine whether or not there are any dif ferences in excretion of catecholamines between patients with essential hyperten sion and normal subjects by measuring the urinary output of norepinephrine (NE), epinephrine (E), normetanephrine (NMN), metanephrine (MN) and vanillyl mandelic acid (VMA) in sleep and at walking. MATERIALS AND METHODSUrinary excretion of NE and E, conjugated NMN and MN, and VMA at walk ing and in sleep was measured in 10 hypertensive subjects aged 20 to 47 years (averaging 37 years) with systolic blood pressure over 150mm Hg and/or diastolic

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Urinary normetadrenaline excretion in essential hypertension

Cited by 16 publications

References 8 publications

Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs

Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs

The Excretion of Free Noradrenaline and Adrenaline by Healthy Young Subjects and by Patients With Essential Hypertension

Urinary Excretion of Catecholamine Derivatives in Essential Hypertension

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