Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Ferguson, Kelly K.; McElrath, Thomas F.; Pace, Gerry G.; Weller, David M.; Zeng, Lixia; Pennathur, Subramaniam; Cantonwine, David E.; Meeker, John D.

doi:10.1021/acs.est.7b01252

Cited by 105 publications

(47 citation statements)

References 48 publications

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“…48 Effects of exposure to PAHs may start prenatally, as suggested by associations between maternal PAH exposure and childhood obesity. 49 Urinary PAH metabolites are associated with higher levels of markers of inflammation and oxidative stress during pregnancy, 50 indicating potential systemic impacts of PAH exposure that could impact pregnancy and development. Emerging evidence that PAHs may alter levels of reproductive hormones in umbilical cord sera 51 provides a further link between maternal exposures and potential prenatal impacts.…”

Section: Discussionmentioning

confidence: 99%

Association of urinary polycyclic aromatic hydrocarbons and obesity in children aged 3–18: Canadian Health Measures Survey 2009–2015

Bushnik

Wong

Holloway

et al. 2019

J Dev Orig Health Dis

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Polycyclic aromatic hydrocarbons (PAHs) may contribute to obesity. Childhood obesity is a strong predictor of adult obesity and morbidity; however, the relationship between PAHs and obesity in young children (e.g., aged 3–5) has not been studied. We examined the association between urinary PAH metabolites and measures of obesity in children. We analyzed data from 3667 children aged 3–18 years who participated in the Canadian Health Measures Survey (CHMS, 2009–2015). We ran separate multivariable linear models to estimate the association between quartiles of PAH metabolites and each of body mass index (BMI) percentile, waist circumference (WC), and waist-to-height ratio (WHtR) in the total population, as well as in the age subgroups 3–5, 6–11, and 12–18, adjusting for age, sex, ethnicity, education, income quintile, diet, creatinine, and exposure to environmental tobacco smoke. A multinomial logistic regression model estimated adjusted odds ratios for risk of central obesity. BMI, WC, and WHtR were positively associated with total PAH and naphthalene metabolites in the total population aged 3–18 and in age groups 6–11 and 12–18. In 3–5 year olds, WHtR, but not BMI, was significantly associated with total PAH, naphthalene, and phenanthrene metabolites. Overall, those in the highest quartile for naphthalene or total PAH metabolites had three times greater odds of having central obesity compared with those in the lowest quartile. Urinary PAH metabolites are associated with WHtR, an indicator of central obesity and predictor of health risks associated with obesity, in children as young as 3–5.

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Section: Discussionmentioning

confidence: 99%

Association of urinary polycyclic aromatic hydrocarbons and obesity in children aged 3–18: Canadian Health Measures Survey 2009–2015

Bushnik

Wong

Holloway

et al. 2019

J Dev Orig Health Dis

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“…All exposure analytes were measured in urine samples by NSF International in Ann Arbor, MI. Quantification of individual toxicants and analytes followed protocols developed by the Centers for Disease Control and Prevention [44][45][46][47] . We used high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) to quantify a total of nine phthalate metabolites.…”

Section: Methodsmentioning

confidence: 99%

Application of an analytical framework for multivariate mediation analysis of environmental data

et al. 2020

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Diverse toxicological mechanisms may mediate the impact of environmental toxicants (phthalates, phenols, polycyclic aromatic hydrocarbons, and metals) on pregnancy outcomes. In this study, we introduce an analytical framework for multivariate mediation analysis to identify mediation pathways (q = 61 mediators) in the relationship between environmental toxicants (p = 38 analytes) and gestational age at delivery. Our analytical framework includes: (1) conducting pairwise mediation for unique exposure-mediator combinations, (2) exposure dimension reduction by estimating environmental risk scores, and (3) multivariate mediator analysis using either Bayesian shrinkage mediation analysis, population value decomposition, or mediation pathway penalization. Dimension reduction demonstrates that a one-unit increase in phthalate risk score is associated with a total effect of 1.07 lower gestational age (in weeks) at delivery (95% confidence interval: 0.48–1.67) and eicosanoids from the cytochrome p450 pathway mediated 26% of this effect (95% confidence interval: 4–63%). Eicosanoid products derived from the cytochrome p450 pathway may be important mediators of phthalate toxicity.

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“…Similarly, urinary 8isoprostane (8-iso-PGF2α), the terminal product of cell membrane lipidperoxidation with strong chemical stability, could reflect oxidative damage of lipids [18,19]. Both epidemiology and toxicology studies have observed elevated levels of oxidative damage along with PAH exposure [12,18,20].…”

Section: Introductionmentioning

confidence: 99%

Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

Cao

Zhou

Tan³

et al. 2020

Environ Health

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Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) is related to decreased lung function. However, whether oxidative damage is involved in this relationship remains unclear. This study was aimed to explore the potential mediating role of oxidative DNA or lipid damage in the association between PAH exposure and lung function. Methods: The urinary levels of monohydroxy polycyclic aromatic hydrocarbon metabolites (OH-PAHs) and lung function parameters were measured among 3367 participants from the baseline of the Wuhan-Zhuhai cohort. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-isoprostane (8-iso-PGF2α) were determined to evaluate the individuals' oxidative DNA and lipid damage degrees, respectively. Linear mixed models were used to investigate the associations of urinary OH-PAHs, 8-OHdG and 8-iso-PGF2α with lung function parameters. Mediation analysis was further conducted to assess the potential role of oxidative damage in the association between urinary OH-PAHs and lung function. Results: Each one-percentage increase in the sum of urinary OH-PAHs, high-molecular-weight or low-molecular-weight OH-PAHs (ƩOH-PAHs, ƩHMW OH-PAH or ƩLMW OH-PAHs, respectively) was associated with a 0.2152-, 0.2076-or 0.1985ml decrease in FEV 1 , and a 0.1891-, 0.2195-or 0.1634-ml decrease in FVC, respectively. Additionally, significantly positive dose-response relationships of ƩOH-PAHs, ƩHMW OH-PAH and ƩLMW OH-PAHs with urinary 8-OHdG or 8-iso-PGF2α, as well as an inverse dose-response relationship between urinary 8-OHdG and FVC, were observed (all P for trend < 0.05). Mediation analysis indicated that urinary 8-OHdG mediated 14.22% of the association between ƩHMW OH-PAH and FVC. Conclusion: Higher levels of oxidative DNA damage might be involved in the decreased levels of FVC caused by highmolecular-weight PAH exposure.

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Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Cited by 105 publications

References 48 publications

Association of urinary polycyclic aromatic hydrocarbons and obesity in children aged 3–18: Canadian Health Measures Survey 2009–2015

Association of urinary polycyclic aromatic hydrocarbons and obesity in children aged 3–18: Canadian Health Measures Survey 2009–2015

Application of an analytical framework for multivariate mediation analysis of environmental data

Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

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