Urinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project

Bartolomé, Mónica; Ramos, Juan José; Cutanda, Francisco; Huetos, Olga; Esteban, Marta; Ruiz-Moraga, Montserrat; Calvo, Eva; Pérez‐Gómez, Beatriz; González, O.; Castaño, Argelia

doi:10.1016/j.chemosphere.2014.12.008

Cited by 48 publications

(15 citation statements)

References 38 publications

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“…In the presented study, alththough not statistically significant, slightly higher results were noted for women than for men (geometric means: 0.57 μg/g for men vs. 0.64 μg/g for women). Similarly, Bertolome et al described higher, but not statistically significant, 1-OHP concentration for women [27]. On the other hand, a study published by Yamano et al for a non-exposed group reported a geometric mean equal to 0.52 μmol/mol (1 μg/g), which is higher than the presented results for both groups, coke plant workers: 0.83 μg/g and control: 0.61 μg/g.…”

Section: Discussioncontrasting

confidence: 51%

Urinary 1-hydroxypyrene in occupationally-exposed and non-exposed individuals in Silesia, Poland

Zając

Gomółka²,

Szot

2018

Ann Agric Environ Med.

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Introduction. The aim of presented study was comparison of urinary 1-hydroxypyrene concentration among coke plant workers (before and after working week) and among non-exposed individuals from the same area, taking smoking status into consideration. Materials and method. 647 coke plant workers and 206 individuals living in the same area were analysed with respect to urinary 1-OHP concentration and smoking status. Urinary samples were measured using high performance liquid chromatography (HPLC) with fluorescent detection. Concentrations were normalized with respect to creatinine concentration. For workers, two samples were collected before and after working week. Multiple regression was performed to distinguish and quantify the influence of cigarette smoking and occupational PAH exposition on the urinary 1-OHP levels. Results. Average urinary 1-OHP concentration of samples collected before the working week was: 1.07 μg/g; after the working week: 2.36 μg/g and for control: 0.74 μg/g. The samples collected at the beginning of the working week were not suitable for assessment of the workers' background (non-occupational) exposition. Smoking cigarettes induced a rise in urinary 1-OHP level by 16%, on average (CI: 5% -28%), and working for a whole working week at the coke plant made urinary 1-OHP levels, on average, 3.21 times higher (CI: 2.91 -3.54). Conclusions. Working at the coke plant increases significantly urinary 1-OHP concentration in comparison to nonoccupationally exposed individuals, both for samples collected before and after the working week. Smoking remains a significant source of PAHs exposition, despite the fact that occupational exposure is greater. Health promotion programmes should address both the occupational health risks reduction and smoking prevention.

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Section: Discussioncontrasting

confidence: 51%

Urinary 1-hydroxypyrene in occupationally-exposed and non-exposed individuals in Silesia, Poland

Zając

Gomółka²,

Szot

2018

Ann Agric Environ Med.

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“…In human, Sul et al (2012) observed significantly higher levels of urinary 2-OHNap in men than females, and suggested that gender were predictors of urinary 2-OHNap concentrations. 1-9-OHPhe on the other hand was significantly higher in female cattle (GM SG = 2.17 ± 1.18 ng/mL) than males (GM SG = 1.71 ± 1.07 ng/mL) (Table 4), while ∑OHPhes in women were low compared to men (Bartolomé et al, 2015). These differences could be due to variations in metabolism, levels and route of exposure to PAHs.…”

Section: Association Between Urinary Oh-pahs Concentrations and Sexmentioning

confidence: 96%

“…Gender differences have been used in various studies to predict differences in OH-PAHs concentrations in human (Sul et al 2012;Levine et al, 2015;Bartolomé et al, 2015;CDC, 2015). Study by Thai et al (2016) in human urine showed no association between sex and urinary OH-PAHs concentrations.…”

Section: Association Between Urinary Oh-pahs Concentrations and Sexmentioning

confidence: 99%

Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana

Bortey-Sam

Ikenaka

Akoto

et al. 2016

Environmental Pollution

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Previous studies of polycyclic aromatic hydrocarbons (PAHs) in particulate matter, soils and livers of wild rats indicated that the city centre of Kumasi, Ghana has been severely polluted with high cancer potency. Cattle urine were therefore collected from Kumasi (urban) and Offinso (rural), Ghana: to determine concentrations of urinary PAH metabolites (OH-PAHs); and find their association with sex; and to estimate exposure of cattle to PAHs from the different sites. From the results, geometric mean concentrations (adjusted by specific gravity), GM, showed that 2-OHNaphthalene (2-OHNap) was the most abundant OH-PAH in cattle urine from all study sites, and naphthalene-containing-mothballs might have contributed significantly to the levels. There was no significant difference between urinary OH-PAHs concentrations in cattle from urban and rural sites except for 2-OHPhe and 4-OHPhe, and similar to urban areas, rural sites could also be polluted with PAHs. GM of 2-OHNap in cattle urine in Kokote (21.9 ± 6.51 ng/mL; a rural area), was significantly higher compared to the other sites followed by Oforikrom (4.15 ± 4.37 ng/mL; urban). The GM concentration (ng/mL) of the sum of OH-PAHs decreased in the order, Kokote (44.7) > Oforikrom (7.87) > Saboa (6.98) > Santasi (6.68) > and Twumasen Estate (5.23). The high concentrations of urinary 2-OHNap, 2-3-OHFlu, 2-OHPhe, 3-OHPhe and 4-OHPhe in Kokote indicated high PAHs exposure to cattle in this area or different/specific source of PAHs exposure. GM of 2-OHNap was significantly higher in male cattle compared to females while 1-9-OHPhe was significantly higher in females.

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“…Gender and age differences have been used in various studies to predict differences in OH-PAHs concentrations in humans (Bartolomé et al 2015;Levine et al 2015, Sul et al 2012). As shown in Table 2, there was no association between urinary OH-PAHs concentrations and age, which is similar to study by Thai et al (2016 Laryea et al 2014).…”

Section: Association Between Urinary Oh-pahs Mda 8-ohdg With Agementioning

confidence: 99%

“…Emerging evidence also indicates that women may be at greater risk of lung cancer than men, because the elevated activity of CYP1A1 enzymes in women can produce higher levels of DNA adducts, and women have lower DNA repair capacity than men (Mollerup et al 2006;Uppstad et al 2011). In contrast, Sul et al (2012) and Bartolomé et al (2015) observed significantly higher levels of urinary 2-OHNap and ∑OHPhes, respectively, in men than females, and suggested that gender were predictors of urinary 2-OHNap concentrations (Sul et al 2012). These differences could be due to variations in levels and route of exposure to PAHs.…”

Section: Association Between Urinary Oh-pahs Mda 8-ohdg With Sexmentioning

confidence: 99%

Oxidative stress and respiratory symptoms due to human exposure to polycyclic aromatic hydrocarbons (PAHs) in Kumasi, Ghana

Bortey-Sam

Ikenaka²,

Akoto

et al. 2017

Environmental Pollution

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Studies of polycyclic aromatic hydrocarbons (PAHs) and its metabolites in PM10, soils, rat livers and cattle urine in Kumasi, Ghana, revealed high concentrations and cancer potency. In addition, WHO and IARC have reported an increase in cancer incidence and respiratory diseases in Ghana. Human urine were therefore collected from urban and control sites to: assess the health effects associated with PAHs exposure using malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG); identify any association between OH-PAHs, MDA, 8-OHdG with age and sex; and determine the relationship between PAHs exposure and occurrence of respiratory diseases. From the results, urinary concentrations of the sum of OH-PAHs (∑OHPAHs) were significantly higher from urban sites compared to the control site. Geometric mean concentrations adjusted by specific gravity, GM, indicated 2-OHNaphthalene (2-OHNap) (6.01 ± 4.21 ng/mL) as the most abundant OH-PAH, and exposure could be through the use of naphthalene-containing-mothballs in drinking water purification, insect repellent, freshener in clothes and/or "treatment of various ailments". The study revealed that exposure to naphthalene significantly increases the occurrence of persistent cough (OR = 2.68, CI: 1.43-5.05), persistent headache (OR = 1.82, CI: 1.02-3.26), tachycardia (OR = 3.36, CI: 1.39-8.10) and dyspnea (OR = 3.07, CI: 1.27-7.43) in Kumasi residents. Highest level of urinary 2-OHNap (224 ng/mL) was detected in a female, who reported symptoms of persistent cough, headache, tachycardia, nasal congestion and inflammation, all of which are symptoms of naphthalene exposure according to USEPA. The ∑OHPAHs, 2-OHNap, 2-3-OHFluorenes, and -OHPhenanthrenes showed a significantly positive correlation with MDA and 4-OHPhenanthrene with 8-OHdG, indicating possible lipid peroxidation/cell damage or degenerative disease in some participants. MDA and 8-OHdG were highest in age group 21-60. The present study showed a significant sex difference with higher levels of urinary OH-PAHs in females than males.

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Urinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project

Cited by 48 publications

References 38 publications

Urinary 1-hydroxypyrene in occupationally-exposed and non-exposed individuals in Silesia, Poland

Urinary 1-hydroxypyrene in occupationally-exposed and non-exposed individuals in Silesia, Poland

Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana

Oxidative stress and respiratory symptoms due to human exposure to polycyclic aromatic hydrocarbons (PAHs) in Kumasi, Ghana

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