Urinary protein carbonyl levels and its correlation with protein misfolding in preeclampsia

Nagarajappa, Chandrakala; Rangappa, Sheela Shikaripur; Suryanarayana, Ravishankar; Balakrishna, Sharath

doi:10.1080/10641955.2019.1590720

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activated partial thromboplastin time, thrombin time, prothrombin time, fibrinogen, D‐Dimer, and fibrinogen stand as critical indicators of blood coagulation and fibrinolysis. Research suggests their intricate connection topreeclampsiadevelopment 27,28 . Our study revealed that severe preeclampsia patients exhibited elevated levels of urinary protein, quantitative urinary protein, activated partial thromboplastin time, and thrombin time, coupled with lower fibrinogen levels compared to mild preeclampsia and pregnancy‐induced hypertension patients.…”

Section: Discussionmentioning

confidence: 62%

“…Research suggests their intricate connection topreeclampsiadevelopment. 27,28 Our study revealed that severe preeclampsia patients exhibited elevated levels of urinary protein, quantitative urinary protein, activated partial thromboplastin time, and thrombin time, coupled with lower fibrinogen levels compared to mild preeclampsia and pregnancy-induced hypertension patients. Similarly, mild preeclampsia patients displayed higher levels of urinary protein, quantitative urinary protein, activated partial thromboplastin time, and thrombin time, along with lower fibrinogen levels than pregnancy-induced hypertension patients (P < .05).…”

Section: Sharma Et Al's Research Emphasizes a Strong Correlationmentioning

confidence: 74%

See 1 more Smart Citation

Urinary protein and coagulation‐fibrinolysis indicators in preeclampsia: Expression and significance

Chen,

Fang,

2024

J of Clinical Hypertension

View full text Add to dashboard Cite

This study investigates the expression and significance of urinary protein and coagulation‐fibrinolysis indicators in preeclampsia, categorized into mild preeclampsia (109 cases) and severe preeclampsia (97 cases) based on disease severity. Additionally, 110 patients with gestational hypertension (gestational hypertension group) were included for comparative analysis. General information, laboratory indicators, urinary protein, and coagulation‐fibrinolysis indicator levels were collected for each group. Significant differences were observed in blood pressure among groups (P < .05), while uric acid, serum creatinine, aspartate transaminase, alanine transaminase, and triglycerides showed no significant differences (P > .05). Total cholesterol, triglycerides, and low‐density Lipoprotein levels in severe preeclampsia were higher than those in mild preeclampsia and gestational hypertension groups, whereas high‐density lipoprotein, albumin, and platelet levels were lower in severe preeclampsia. No significant differences were observed in prothrombin time or D‐dimer levels among groups (P > .05). Urinary protein, urinary protein quantification, activated partial thromboplastin time, thrombin time, and fibrinogen were identified as influencing factors for adverse maternal and infant outcomes in severe preeclampsia patients. The study concludes that urinary protein and coagulation‐fibrinolysis indicators are elevated in preeclampsia, particularly in severe preeclampsia cases, suggesting their potential use as diagnostic influencing factors for severe preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Sharma Et Al's Research Emphasizes a Strong Correlationmentioning

confidence: 74%