Urinary schistosomiasis in migrant population: a case series from a single centre in southern Italy

Milesi, M; Indovina, Claudia; Dino, Ornella; Bella, F Di; Lorenzo, Francesco Di; Sanfilippo, Adriana; Bernardo, Francesca Di; Sodano, Concetta; Prestileo, Tullio; Palermo, Immigrant Take Care Advocacy team

doi:10.1007/s15010-018-1244-z

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…According to the WHO's preventive chemotherapy and transmission control (PCT) for schistosomiasis, other countries have a high relative risk of schistosomiasis [20], at the univariable logistic regression model, origin from Mali was a significant predictor for urogenital schistosomiasis, in our study.…”

Section: Discussionmentioning

confidence: 47%

Human urogenital schistosomiasis in West and Sub-Saharan Africa migrants in Sardinia, Italy: A retrospective monocentric study

Geremia

Vito

Lai

et al. 2022

J Infect Dev Ctries

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Introduction: Schistosoma (S.) haematobium is the aetiological agent of urogenital schistosomiasis endemic in Sub-Saharan Africa and the Middle East. Microhaematuria is strongly associated with schistosomiasis diagnosis. Praziquantel (PZQ) is the treatment of choice. Methodology: We conducted a monocentric survey among African migrants from January 2017 to December 2018. The diagnosis of S. haematobium was performed by direct microscopic examination of urine. The treatment was PZQ 40 mg/Kg/die for three days. Results: We enrolled 91 male patients with a median age of 20.2 years (IQR 18.9-23.4)]. Forty-five (49.5%) described a history of haematuria. Sixteen (17.6%) evidenced the presence of red blood cells (RBCs) during urine microscopy. Eighteen (19.8%) had urogenital schistosomiasis. Their median white blood count (WBC) was 5.15 x 109/L (IQR 4.45-6.08) and it was 6.37 x 109 /L (IQR 5.14-8.27), p = 0.009, after 15 days from treatment. Baseline eosinophil count was 0.5 x 109/L (IQR 0.3-0.6) and 0.7 x 109/L (IQR 0.2-1.9; p = 0.032). According to the univariate analysis, origin from Mali [odds ratio (OR) 3.6 (CI 1.2-10.9), p = 0.022] and microscopic evidence of RBCs [OR of 10.7 (CI 2.5-45.1), p = 0.001] were main predictors of urogenital schistosomiasis diagnosis. One (5.6%) treatment failure was registered. Three (16.7%) patients had bladder cancer. Conclusions: Detection of RBCs was a significant predictor of S. haematobium infection and could be used as a screening method in migrants coming from endemic areas. Early urogenital schistosomiasis diagnosis and ultrasound diagnostic tools are crucial for reducing the risk of potential neoplastic evolution.

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Section: Discussionmentioning

confidence: 47%

Human urogenital schistosomiasis in West and Sub-Saharan Africa migrants in Sardinia, Italy: A retrospective monocentric study

Geremia

Vito

Lai

et al. 2022

J Infect Dev Ctries

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“…Bergquist (2013) reported the spread of the disease to regions that were previously non-endemic. These include reported cases of urinary schistosomiasis in adolescent refugee from Gambia (Poddighe et al, 2016) and 214 male migrant patients Milesi et al (2019) all in Italy. Uysal et al (2014) also reported a rare case of a 22-year-old Nigerian with urinary schistosomiasis in Turkey.…”

Section: Introductionmentioning

confidence: 99%

An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis

Onile

Fadahunsi

Adekunle

et al. 2020

PeerJ

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Discovery of T and B memory cells capable of eliciting long-term immunity against schistosomiasisis is important for people in endemic areas. Changes in schistosomes environment due to developmental cycle, induces up-regulation of Heat Shock Proteins (HSPs) which assist the parasite in coping with the hostile conditions associated with its life cycle. This study therefore focused on exploring the role of HSPs in urogenital schistosomiasis to develop new multi-epitope subunit vaccine against the disease using immunoinformatic approaches. The designed subunit vaccine was subjected to in silico antigenicity, immunogenicity, allergenicity and physicochemical parameters analysis. A 3D structure of the vaccine construct was predicted, followed by disulphide engineering for stability, codon adaptation and in silico cloning for proper expression and molecular protein–protein docking of vaccine construct in the vector against toll-like receptor 4 receptor, respectively. Consequently, a 493 amino acid multi-epitope vaccine construct of antigenicity probability of 0.91 was designed. This was predicted to be stable, non-allergenic in nature and safe for human use.

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Urogenital schistosomiasis detected in sub-Saharan African migrants attending primary healthcare consultations in Paris, France: a 14-year retrospective cohort study (2004–2017)

Deniaud

Vignier

Collignon³

et al. 2020

Eur J Clin Microbiol Infect Dis

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Urinary schistosomiasis in migrant population: a case series from a single centre in southern Italy

Cited by 6 publications

References 11 publications

Human urogenital schistosomiasis in West and Sub-Saharan Africa migrants in Sardinia, Italy: A retrospective monocentric study

Human urogenital schistosomiasis in West and Sub-Saharan Africa migrants in Sardinia, Italy: A retrospective monocentric study

An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis

Urogenital schistosomiasis detected in sub-Saharan African migrants attending primary healthcare consultations in Paris, France: a 14-year retrospective cohort study (2004–2017)

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