Urinary Screening and Urinary Abnormalities in 3-year-old Children in Japan

Yanagihara, Takashi

doi:10.1272/manms.12.86

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…In Japan, urine screening using dipsticks in 3-year-old children has been carried out for identification of CAKUT, but it has not been very useful (14). Sekhar et al reported that urine dipstick screening is a poor test for CKD and is not cost-effective (15).…”

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confidence: 99%

Development of tandem mass spectrometry-based creatinine measurement using dried blood spot for newborn mass screening

et al. 2017

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BackgroundCongenital anomalies of the kidney and urinary tract (CAKUT) are the most prevalent etiologies of pediatric chronic kidney disease (CKD). However, no robust mass screening methods have been developed to detect patients with CAKUT, making early intervention to prevent progressive renal failure challenging.MethodsWe applied tandem mass spectrometry (MS/MS) to measure the creatinine (Cr) value from dried blood spot (DBS) analysis, which has been used for newborn mass screening. Subsequently, we evaluated the correlation between DBS Cr measured by MS/MS and serum Cr measured by the conventional method in pediatric patients with CKD. Finally, DBS Cr was measured in 190 full-term, healthy newborns on days 4-6 after birth.ResultsWe established a system of MS/MS-based measurement of Cr from DBS. Measured DBS Cr in the pediatric patients showed a strong association with serum Cr (r=0.86; P<0.01). The median DBS Cr value in newborns was 0.222 (interquartile range: 0.189, 0.269) mg/dl. No significant correlations were found between DBS Cr values and body weight, Apgar score, gestational age, and sex in newborns.ConclusionWe successfully established a method for MS/MS-based measurement of Cr for newborn screening and determined normal reference values for full-term newborns.

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confidence: 99%

Development of tandem mass spectrometry-based creatinine measurement using dried blood spot for newborn mass screening

et al. 2017

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“…The study by Yanagahira reported that false positives are common in leucocyturia examination using a dipstick. 24 Another study reported that postoperative bacteriuria was a common phenomenon found in up to 51% cases, and thus broad-spectrum prophylaxis and postoperative antibiotics were recommended in order to decrease the risk of UTI which may contribute to fistula formation. 23 Other studies reported that pre- and postoperative positive swab results may contribute to wound infection and suggested antibiotic therapy based on the preoperative perimeatal swab.…”

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confidence: 99%

Single-stage urethroplasty: An eight-year single-centre experience and its associated factors for urethrocutaneous fistula

Satjakoesoemah

Situmorang

Wahyudi

et al. 2020

Journal of Clinical Urology

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Introduction: This study aimed to describe single-stage urethroplasty and to determine factors associated with urethrocutaneous fistula after the procedure at our institution. Methods: All hypospadias patients without any prior surgery who underwent single-stage urethroplasty from July 2010 to January 2018 were included. In total, 179 patients were followed for at least one year postoperatively. Information on types of hypospadias, operation techniques, chordee degree, preoperative pyuria (urine white blood cell count >5/HPF), urethral defect length and urethrocutaneous fistula formation was collected. Results: We obtained 103 cases of posterior (57.5%), middle (57 cases) and anterior (19 cases) hypospadias on whom onlay preputial island flap (71 cases), tubularized incised plate (46 cases) and Duckett’s transverse preputial island flap (35 cases) were conducted. After 47.1±25.8 months of follow-up, urethrocutaneous fistula were found in 23 (12.8%) patients associated with posterior hypospadias occurrence ( p=0.025), longer urethral defect ( p=0.007) and preoperative pyuria ( p<0.001). Chordee degree ( p=0.886) and age ( p=0.187) were not significant factors associated with urethrocutaneous fistula formation. Conclusion: Single-stage urethroplasty is a versatile procedure for various hypospadias cases, with a urethrocutaneous fistula rate of 12.8%. Posterior hypospadias, preoperative pyuria and longer urethral defect were associated with urethrocutaneous fistula formation. Level of evidence Level 2B.

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Urinary Screening and Urinary Abnormalities in 3-year-old Children in Japan

Cited by 2 publications

References 4 publications

Development of tandem mass spectrometry-based creatinine measurement using dried blood spot for newborn mass screening

Development of tandem mass spectrometry-based creatinine measurement using dried blood spot for newborn mass screening

Single-stage urethroplasty: An eight-year single-centre experience and its associated factors for urethrocutaneous fistula

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