Urinary sevoflurane and hexafluoro-isopropanol as biomarkers of low-level occupational exposure to sevoflurane

Accorsi, Antonio; Morrone, Barbara; Domenichini, I.; Valenti, S; Raffi, Giovanni Battista; Violante, Francesco Saverio

doi:10.1007/s00420-004-0580-8

Cited by 26 publications

(14 citation statements)

References 37 publications

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“…When FGF ¼ MV, FI will go up to (and stabilize at) FD because the exhaled TV is not part of the next inhaled TV after the circuit is filled with the FD of sevoflurane gas, provided that the atmospheric pressure and the temperature difference between the patient's body and the operating room are all constant. All of the inhaled sevoflurane is equal to the sum of the volume that is dissolved in blood 9 and tissue fluid, bound with proteins in plasma and tissue fluid, metabolized by the liver, ejected by the kidneys, 10,11 shed through blood loss and dispersed through the raw operating surface and skin. Once FI is equal to FD and stable, F A , F a and F t will be stable when the volume of sevoflurane ejected through the nonrespiratory tract route (i.e.…”

Section: Discussionmentioning

confidence: 99%

Establishing the relationship between FGF/MV and FI/FD, and determining the saturation state of sevoflurane anaesthesia during the induction phase and factors affecting nonrespiratory tract ejection volume

Zhiyang

2013

J Int Med Res

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Objectives: To investigate (i) the relationship between the ratio of fresh gas flow to min volume (FGF/MV) and the ratio of the fraction of inspired sevoflurane to the delivered concentration of sevoflurane (FI/FD); (ii) to establish the saturation state of sevoflurane anaesthesia and factors affecting the volume of ejected sevoflurane through the nonrespiratory tract route (nVERT) during the saturation state. Methods: Two studies were undertaken in patients with cancer, scheduled to undergo surgery. All patients received tracheal intubation and inhaled sevoflurane. In study 1, anaesthesia parameters were fixed, the initial FD of sevoflurane was 2.2% vol and the FGF/MV was set to 0.2, 0.3, 0.4 and 1.0 in groups A, B, C and D, respectively. In study 2, FGF ¼ MV and the initial FD of sevoflurane was 2.2% vol, but the tidal volume (TV) was set to 6, 8 or 10 ml/kg in groups I, II and III, respectively. Results: Study 1 (n ¼ 60) showed a positive relationship between FI/FD and FGF/MV. In study 2

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Section: Discussionmentioning

confidence: 99%

Establishing the relationship between FGF/MV and FI/FD, and determining the saturation state of sevoflurane anaesthesia during the induction phase and factors affecting nonrespiratory tract ejection volume

Zhiyang

2013

J Int Med Res

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“…to restore visibility), is therefore accompanied by the release of sevoflurane vapor. Hence, it is an additional source of waste anaesthetic gas (WAG) pollution [59,60,[63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79]. Known sources of WAG pollution include leakage from the patient's mask, from endotracheal coupling, from loose tube fittings and from air exhaled by the patient in the recovery room.…”

Section: Discussionmentioning

confidence: 99%

Chemical analysis of surgical smoke by infrared laser spectroscopy

Gianella

Sigrist

2012

Appl. Phys. B

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The chemical composition of surgical smoke, a gaseous by-product of some surgical devices-lasers, drills, vessel sealing devices-is of great interest due to the many toxic components that have been found to date. For the first time, surgical smoke samples collected during routine keyhole surgery were analyzed with infrared laser spectroscopy. Traces (ppm range) of methane, ethane, ethylene, carbon monoxide and sevoflurane were detected in the samples which consisted mostly of carbon dioxide and water vapor. Except for the anaesthetic sevoflurane, none of the compounds were present at dangerous concentrations. Negative effects on the health of operation room personnel can be excluded for many toxic compounds found in earlier studies, since their concentrations are below recommended exposure limits.

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“…This method provided good correlations with personal monitoring measurements of inhaled ppm concentrations [4]. HFIP has also recently been proposed as an exposure biomarker for operating room personnel [5,6].…”

Section: Introductionmentioning

confidence: 96%

Simultaneous determination of unmodified sevoflurane and of its metabolite hexafluoroisopropanol in urine by headspace sorptive extraction–thermal desorption–capillary gas chromatography–mass spectrometry

Accorsi

Morrone

Benzo

et al. 2005

Journal of Chromatography A

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Urinary sevoflurane and hexafluoro-isopropanol as biomarkers of low-level occupational exposure to sevoflurane

Cited by 26 publications

References 37 publications

Establishing the relationship between FGF/MV and FI/FD, and determining the saturation state of sevoflurane anaesthesia during the induction phase and factors affecting nonrespiratory tract ejection volume

Establishing the relationship between FGF/MV and FI/FD, and determining the saturation state of sevoflurane anaesthesia during the induction phase and factors affecting nonrespiratory tract ejection volume

Chemical analysis of surgical smoke by infrared laser spectroscopy

Simultaneous determination of unmodified sevoflurane and of its metabolite hexafluoroisopropanol in urine by headspace sorptive extraction–thermal desorption–capillary gas chromatography–mass spectrometry

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