Urinary Spermidine Predicts and Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery

Martin‐Lorenzo, Marta; Ramos-Barron, M.A.; Gutierrez-Garcia, P.; Martín-Blázquez, Ariadna; Santiago-Hernandez, A.; Calabia, Emilio Rodrigo; Gómez-Alamillo, C.; Alvarez-Llamas, Gloria

doi:10.3390/antiox10060896

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…35 by conjugation with glycine by hepatic or renal glycine-N-acyltransferase. Though hippuric acid has been implicated in both CKD 36,37 and AKI, 38,39 hippuric acid sulfate has yet to be implicated with kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients

Lim

Xiu

Kuruvilla

et al. 2023

Brit J Clinical Pharma

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AimCisplatin causes acute kidney injury (AKI) in approximately one third of patients. Serum creatinine and urinary output are poor markers of cisplatin‐induced AKI. Metabolomics was utilized to identify predictive or early diagnostic biomarkers of cisplatin‐induced AKI.MethodsThirty‐one adult head and neck cancer patients receiving cisplatin (dose ≥70 mg/m2) were recruited for metabolomics analysis. Urine and serum samples were collected prior to cisplatin (pre), 24–48 h after cisplatin (24–48 h) and 5–14 days (post) after cisplatin. Based on serum creatinine concentrations measured at the post timepoint, 11/31 patients were classified with clinical AKI. Untargeted metabolomics was performed using liquid chromatography‐mass spectrometry (LC‐MS).ResultsMetabolic discrimination was observed between “AKI” patients and “no AKI” patients at all timepoints. Urinary glycine, hippuric acid sulfate, 3‐hydroxydecanedioc acid and suberate were significantly different between AKI patients and no AKI patients prior to cisplatin infusion. Urinary glycine and hippuric acid sulfate were lower (−2.22‐fold and −8.85‐fold), whereas 3‐hydroxydecanedioc acid and suberate were higher (3.62‐fold and 1.91‐fold) in AKI patients relative to no AKI patients. Several urine and serum metabolites were found to be altered 24–48 h following cisplatin infusion, particularly metabolites involved with mitochondrial energetics.ConclusionsWe propose glycine, hippuric acid sulfate, 3‐hydroxydecanedioc acid and suberate as predictive biomarkers of predisposition to cisplatin‐induced AKI. Metabolites indicative of mitochondrial dysfunction may serve as early markers of subclinical AKI.

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Section: Discussionmentioning

confidence: 99%

Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients

Lim

Xiu

Kuruvilla

et al. 2023

Brit J Clinical Pharma

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“…Clinical observational studies or trials on polyamines and AKI are still very few. A case-control observational study reported that patients with high levels of urinary spermidine before cardiac surgery had an increased risk of AKI, suggesting that spermidine may be a novel and promising biomarker to identify those patients at higher predisposition to develop AKI [ 97 ]. However, the role of polyamines in the blood and urine of patients with AKI in diagnosis remains to be further studied.…”

Section: Polyamines In Kidney Diseasesmentioning

confidence: 99%

Metabolism of Polyamines and Kidney Disease: A Promising Therapeutic Target

Luo,

Lu,

et al. 2023

Kidney Dis

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Background: More than 850 million people worldwide suffer from acute and chronic kidney diseases (CKD) which are tremendous socioeconomic burdens for society. Currently, the treatment choices for CKD are limited. There is a great need to understand the underlying mechanisms of the development of CKD in order to develop potential therapeutic strategies. Summary: The alteration in cellular metabolism has emerged as an important common pathological mechanism in different kidney diseases. Metabolic intervening and reprogramming will yield new insights to prevent and slow the progression of kidney disease. As one essential component of cellular metabolisms in fuel-source preferences (glucose, fatty acids, or ketones), the polyamine compound metabolism comprising the metabolites (spermine, spermidine, and putrescine) and their biosynthetic and catabolic enzymes are an endogenous pathophysiological regulator that is arising as a potential therapeutic object for many diseases. Key Messages: This article aims to review current knowledge on polyamine metabolism and physiological processes, and its potential regulatory and beneficial roles in immunoregulation, mitochondrial homeostasis, autophagy, DNA damage, and kidney diseases, and thus provide a novel therapeutic opportunity for kidney diseases.

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“…Most of these strategies still require large-scale intervention experiments to prove their effectiveness [10]. Furthermore, AKI occurs soon after surgery (typically within the first 6 hours), which means that doctors have a short time to intervene [11]. This emphasizes the critical need for early screening to distinguish patients at high risk and to optimize perioperative care in everyday clinical practice [12].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Novel Nomogram for Predicting Perioperative Acute Kidney Injury Following Isolated Off-Pump Coronary Artery Bypass Grafting Surgery

Shoulei Chen,

Cheng Luo,

Chen Fang

et al. 2023

HSF

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Background: The aim of this work was to create a novel model for predicting acute kidney injury (AKI) after off-pump coronary artery bypass graft (OPCABG). Methods: The individuals who underwent OPCABG were randomly separated into a derivation group and a validation group, at a 7:3 ratio. The primary outcome was AKI under the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. To optimize feature selection and construct a nomogram, both least absolute shrinkage and selection operator regression (LASSO) and logistic regression analysis were utilized. The nomogram was assessed in various ways: with the C-index, calibration curve, decision curve analysis (DCA), and clinical impact curve analysis (CICA). Results: The use of an intra-aortic balloon pump (IABP), systolic blood pressure, smoking and baseline serum creatinine were identified as independent impact factors. The C-index of the nomogram was 0.733 (95% confidence interval (CI) = 0.669–0.791) and 0.786 (95% CI = 0.693–0.878) in the training and validation groups, respectively. The area under the curve (AUC) of the internal validation was 0.715 using bootstrapping with 1000 replicates. The calibration plot revealed that the predicted outcomes aligned well with the observations. DCA and CICA suggested that the model had clinical benefit. Conclusion: The nomogram that relied on clinical characteristics proved to be a dependable instrument to predict AKI after OPCABG. This model is conveniently applicable in clinical settings and will be a valuable resource for assessing timely medical measures to mitigate risk.

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Urinary Spermidine Predicts and Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery

Cited by 6 publications

References 38 publications

Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients

Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients

Metabolism of Polyamines and Kidney Disease: A Promising Therapeutic Target

Development and Validation of a Novel Nomogram for Predicting Perioperative Acute Kidney Injury Following Isolated Off-Pump Coronary Artery Bypass Grafting Surgery

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